Cov xwm txheej tam sim no ntawm Pharmacological teebmeem ntawm Glycosides Ntawm Cistanches Herba

Tom ntej: Glycosides ntawm cistanche (GCs)yogcov khoom xyaw nquag, uas antioxidant thiab anti-aging, exert neuroprotection, ischemia-reperfusion, kev tiv thaiv kab mob, hepatoprotective, dyszoospermiatreatment. Hauv tsab xov xwm no, cov tshuaj pharmacological ntawm GCs raug tshuaj xyuas los muab cov ntaub ntawv siv rau cov kev tshawb fawb ntsig txog thiab kev siv tshuaj kho mob.

Ntsiab lus: glycosides ntawm cistanche;pharmacological teebmeem; tshawb fawb xwm txheej

Cistanche tag nrho glycosides(GCs) tau muab rho tawm los ntawm Cistanche - tsev neeg sib xyaw ua ke ntawm peb ntu: caffeic acid, glycosyl, thiab phenyl ethanol aglycone. Cov kev tshawb fawb tau pom tias GCs muaj ntau yam teebmeem xws li kev txhim kho kev kawm thiab kev txawj ntse,tiv thaiv myocardial ischemia, antioxidant, tshem tawm cov dawb radicals hauv vitro, nce tib neeg kev tiv thaiv, thiab ncua kev laus. Kab lus no tshuaj xyuas cov kev tshawb fawb ntawm cov tshuaj pharmacological ntawm CCs nyob rau hauv xyoo tas los no thiab ua haujlwm raws li kev siv rau kev tshawb fawb thiab kev siv tshuaj kho mob. Qhov chaw ntawmCistanche tag nrho glycosides.

Nyem qhov no kom paub meej txog Desert Ginseng

Cistancheyog lub qia qhuav nrog scaly nplooj ntawm Orobanchiaceae cog Cistanche . Nws yog perennial parasitic noob nroj tsuag, feem ntau hu ua Cistanche . Nws yog sov, qab zib, thiab qab ntsev, rov qab mus rau lub raum thiab cov hnyuv loj meridians, thiab muaj cov teebmeem ntawm nourishing raum yang, replenishing essence thiab ntshav, moistening cov hnyuv, thiab laxative [2]. Kev tshawb fawb tshuaj niaj hnub no qhia tau hais tias Cistanche muaj ntau yam haujlwm xws li kev txhim kho kev sib deev, tswj cov neuroendocrine, txhim kho lub cev tiv thaiv kab mob, antioxidants, txhawb cov tshuaj metabolism, tiv thaiv Alzheimer's kab mob, anti-Parkinson's kab mob, thiab lwm yam.! Cov tshuaj muaj pes tsawg leeg ntawm Cistanche tau txheeb xyuas thiab kawm, thiab ntau hom tshuaj raug cais tawm, xws li polysaccharides, phenylethanoid glycosides, iridoids, lignans, alkaloids, volatile Cheebtsam, thiab lwm yam. Phenylethanol glycoside yog lub ntsiab active ingredient ntawm Cistanche. Inspection indicator for quality control of Cistanche .

2 Pharmacological teebmeem ntawm tag nrho glycosides ntawm Cistanche

2.1 Antioxidant thiab tiv thaiv kev laus

Cov kev tshawb fawb tsis ntev los no ntseeg tias kev laus muaj feem cuam tshuam nrog cov kab mob lipid peroxidation los ntawm cov dawb radicals. Wang Xiaowen et al. [ taw qhia tias CCs tuaj yeem tshem tawm cov dawb radicals hauv vitro thiab tiv thaiv DNA kev puas tsuaj los ntawm OH, thiab xav tias ntau pawg phenolic hydroxyl muaj nyob hauv phenylethanoid glycoside molecules tuaj yeem khi rau dawb radicals hauv lub cev thiab inhibit ultraviolet oxidation hauv cov ntshav thiab lub hlwb. Kev txo qis ntawm oxide dismutase inhibits qhov nce hauv daim siab thiab cov ntsiab lus ntawm malondialdehyde, txo cov tsub zuj zuj ntawm cov dawb radicals hauv lub cev, thiab tiv thaiv lub cev los ntawm kev puas tsuaj peroxidative. Kev tshawb fawb ntxiv tau pom tias phenylethanol glycosides tuaj yeem ncua kev laus ntawm cov nas laus los ntawm kev tswj hwm qhov sib npaug ntawm oxidation / antioxidation ua haujlwm hauv lub cev ntawm cov nas laus. Nws yog speculated tias qhov no muaj feem xyuam rau nws cov kev tiv thaiv ntawm SOD thiab lipid antioxidants. Muaj nuj nqi ntsig txog!

2.2 Neuroprotection

Lub pathogenesis ntawm central neurodegenerative kab mob yog complex, thiab txoj kev xav ntawm dawb radical cell apoptosis yog tam sim no paub txoj kev xav ntawm kev laus!". GCs tuaj yeem txhawb kev loj hlob ntawm neural qia hlwb, thiab Lian Juanqi! Synaptic morphology GCs tuaj yeem txhim kho cov synaptic morphological plasticity ntawm hippocampal neurons nyob rau hauv cov nas laus sai, yog li txhim kho kev kawm thiab kev paub tsis meej ntawm cov nas GCs tuaj yeem ua rau muaj cov kab mob pyramidal hauv thaj tsam CA1 ntawm cov nas tuaj yeem txhim kho morphological plasticity ntawm synapses GCs kuj tuaj yeem txo cov ntsiab lus malondialdehyde hauv cov ntaub so ntswg hauv hlwb, nce superoxide dismutase thiab glutathione peroxidase cov dej num, tiv thaiv cov hlwb los ntawm kev puas tsuaj, thiab inhibit B lymphocytes Kev qhia ntawm Cytoblastoma{1}} (Bcl{{2 }})-hais txog protein X (Bax) txhawb kev qhia ntawm Bcl-2, yog li txhim kho cov ciaj sia taus ntawm pyramidal hlwb hauv hippocampus.

GCs muaj cov txiaj ntsig ntawm kev txhim kho kev kawm muaj peev xwm hauv ntau yam AD nas qauv. Nws tuaj yeem txhim kho cov kev coj cwj pwm zoo ntawm Parkinson tus qauv nas, inhibit acetylcholinesterase kev ua haujlwm thiab Ca cov ntsiab lus hauv nas hippocampal cov ntaub so ntswg, tswj cov qib ntawm acetylcholine hauv lub hlwb, thiab txhim kho nas hippocampal cov ntaub so ntswg. Nws tuaj yeem txhim kho kev kawm thiab kev nco muaj peev xwm ntawm nas, inhibit qhov txo qis ntawm cov dopamine neurons hauv substantia nigra, txhim kho cov haujlwm ntawm cov dawb radical scavenging enzymes, tiv thaiv lipid peroxidation, inhibit qhov deposition ntawm B-amyloid peptide nyob rau hauv lub hlwb, thiab inhibit lub hlwb Apoptosis [9]

2.3 Anti-altitude pulmonary edema thiab cerebral edema

Mob hypoxia ua rau hypoxic pulmonary vasoconstriction, pulmonary vascular endothelial dysfunction, thiab pulmonary vascular remodeling, uas nyob rau hauv lem ua rau plateau pulmonary hypertension. Tao Yicun (] muab Cistanche phenylethanoid glycoside rau nas rau 10 hnub, tsim ib qho qauv nas plateau pulmonary edema nyob rau hnub 8 thiab pom cov kev hloov pauv hauv lub ntsws ntawm cov nas hauv txhua pab pawg. pulmonary edema Cov kev hloov pauv ntawm pulmonary edema hauv cov nas txo cov dej hauv lub ntsws cov ntaub so ntswg, txo cov ntsiab lus ntawm cov kab mob inflammatory thiab malondialdehyde hauv cov ntsws homogenates, thiab nce cov dej num ntawm superoxide dismutase thiab glutathione peroxidase, qhia tias Cistanche phenylethanol glycoside yuav dhau los ntawm. Cov tshuaj tiv thaiv oxidative kev nyuaj siab thiab cov tshuaj tiv thaiv kab mob txhim kho pulmonary edema hauv nas Ntxiv rau, Cistanche phenylethanol glycoside kuj tseem tuaj yeem txhim kho cov tsos mob ntawm cov ntshav siab hauv cov nas uas muaj qhov siab siab pulmonary hypertension, qhia tias nws muaj qee yam hauv kev kho mob siab. qhov siab pulmonary hypertension.

Cistanche phenylethanol glycoside kuj muaj kev tiv thaiv thiab kho cov teebmeem ntawm qhov siab-siab cerebral edema hauv nas. Luo Xin et al. muab tshuaj intragastric rau nas rau kaum hnub. Nyob rau hnub yim, lawv simulated qhov chaw siab tshaj plaws rau 72 teev los tsim ib lub toj siab cerebral edema qauv thiab ntsuas cov dej ntsiab lus ntawm lub paj hlwb, cov ntsiab lus ntawm inflammatory yam, cov ntsiab lus malondialdehyde, thiab superoxide nyob rau hauv lub paj hlwb homogenates. Cov ntsiab lus dismutase thiab glutathione peroxidase kev ua haujlwm qhia tias Cistanche tuaj yeem siv los ua cov tshuaj muaj peev xwm los tiv thaiv qhov siab ntawm lub paj hlwb.

2.4 ischemia-reperfusion

Cov kev tshawb fawb tau qhia tiasischemia-reperfusionyog ib qho tshwm sim ntawm pathophysiological tshwm sim ntawm postoperative lub raum kev puas tsuaj (2]. Zhu Jun et al. (3) tsim ib tug nas ischemic shock resuscitation qauv, thiab tom qab intraperitoneal txhaj ntawm phenylethanol glycosides muab rho tawm los ntawm Cistanche, feem ntau ntawm cov kev qhia ntawm X-chromosome- linked apoptosis inhibitory protein nyob rau hauv nas raum cov ntaub so ntswg yog ho nce, inhibiting cov txheej txheem ntawm lub raum cell apoptosis Cistanche ethanol extract kuj yuav txo tau cov tshuaj hormone-induced adrenal cortex atrophy thiab lub raum tubular epithelial cell o, thiab tiv thaiv lub raum kev ua ub no ntawm superoxide dismutase thiab glutathione peroxidase nyob rau hauv myocardium, txo myocardial ultrafine particle structural puas, thiab txo lipid peroxide (LPO) cov ntsiab lus zoo txhim kho lub electrocardiogram ntawm myocardial ischemia nas, txo myocardial Infarct cheeb tsam thiab nce creatine phosphate myocardial cov ntaub so ntswg (4. Nyob rau tib lub sijhawm, nyob rau hauv cov qauv cerebral ischemia-reperfusion, CCs tuaj yeem txo qhov kev qhia ntawm excitatory amino acids hauv cov ntaub so ntswg hlwb thiab tiv thaiv lub hlwb cov ntaub so ntswg ntawm SD nas. Function [5)