Kev Pom Zoo tam sim no nyob rau hauv Kev Tshawb Fawb Ntawm Cov Tshuaj Tiv Thaiv Kev Laus Los Ntawm Cov Khoom Siv Hluav Taws Xob Part 2

Thov hu rauoscar.xiao@wecistanche.comyog xav paub ntxiv

3 Cov khoom siv ntuj tsim nrog Anti-aging Activity

Txog hnub tim, muaj txog 5, 400 kev tshawb fawb / tshuaj xyuas cov ntawv luam tawm raws li cov ntsiab lus "tiv thaiv kev laus" thiab "tiv thaiv kev laus" (tau los ntawm Web of Science, Tsib Hlis 2017; cov ntsiab lus txwv rau cov ncauj lus: kev tiv thaiv kev laus thiab anti-aging, ntawm kev tshawb fawb ntawm Science & Technology).Anti aging cistancheCov ntawv ceeb toom no tau nthuav tawm ntau dua 300 lub tebchaw nrog kev tiv thaiv kev laus. Ntawm no peb tau sau cov ntsiab lus los yog cov khoom siv ntuj tsim tawm nrog kev ua kom muaj kev tiv thaiv kev laus, suav nrog 185 lub tebchaw los ntawm cov khoom ntuj (Table 1), 55 complex lossis rho tawm los ntawm cov khoom ntuj (Table 2), thiab 62 los ntawm cov tshuaj kho mob (ntawm uas ntau tshaj 50. feem pua ​​kuj yog los ntawm tej yam ntuj tso khoom los yog tej yam ntuj tso khoom analogs, Table 3), 35 los ntawm synthesized chemicals (Table 4). Qee tus ntawm lawv tau txais kev txaus siab thiab nyob rau hauv kev tshawb nrhiav tsis tu ncua, tam sim no cov haujlwm tiv thaiv kev laus hauv ntau cov qauv kev laus, xws li resveratrol [28, 43-53], a-lipoic acid [54-56],

14, 9, thiab 109 cov khoom ntuj tsim nrog kev tiv thaiv kev laus tau tshaj tawm tsuas yog nyob rau hauv nas lossis nas, txiv hmab txiv ntoo yoov, thiab C. elegans, raws li, thaum 14 lub tebchaw nthuav tawm cov haujlwm tiv thaiv kev laus hauv lwm cov qauv kev laus, xws li mammalian hlwb thiab S. .cistanche cov txiaj ntsigcerevisiae. Ntawm 109 lub tebchaw nrog kev tiv thaiv kev laus hauv C. elegans, 18 nrog cov tshuaj tiv thaiv oxidative, tsib txoj kev tswj IIS, plaub tswj AMPK, plaub tswj mTOR signaling, 10 tswj SIR-2.1, rau regulating SKN{{6 }}/Nrf2 txoj hauv kev, xya tswj JNK-1, 16 nrog cov txheej txheem tsis paub, thiab txog ib nrab ntawm 109 qhia ntau yam s qhia los tswj kuv txoj kev sib txuas.

Thov nias ntawm no kom paub ntxiv

Ntawm cov 55 complex extracts los ntawm tej yam ntuj tso khoom, 8, 14, thiab 29 ntawm lawv tau sim nyob rau hauv nas, txiv hmab txiv ntoo yoov, thiab C. elegans, raws li. Feem ntau ntawm cov extracts ua ntej xa tawm cov haujlwm antioxidative.

Ntawm cov tshuaj kho mob 62 nrog kev tiv thaiv kev laus, peb (rapamycin, metformin, caffeine) nthuav tawm cov haujlwm tiv thaiv kev laus hauv peb cov qauv laus, rau (aspirin, berberine, huperzine A, minocycline, phenformin, thiab vitamin E) hauv ob hom kev laus. , ob (buformin thiab melatonin) hauv nas, plaub (ivabradine, acarbose, metoprolol, thiab nebivolol) hauv cov nas, 8 hauv D. melanogaster, 37 hauv C. elegans, cortisone hauv Asplanchna Brightwell thiab myriocin hauv S. cerevisiae, feem. Qhov zoo siab, cov txheej txheem tiv thaiv kev laus ntawm cov tshuaj feem ntau txawv ntawm lawv cov kev siv tshuaj kho mob.

Cistanche tuaj yeem tiv thaiv kev laus

Peb kuj tau sau tseg 35 cov khoom sib xyaw ua ke nrog kev ua kom muaj kev tiv thaiv kev laus (Table 4). 2,4-Dinitrophenol nthuav tawm cov haujlwm tiv thaiv kev laus hauv cov nas thiab txiv hmab txiv ntoo yoov, ethoxyquin, thiab SRT1720 hauv cov nas.Cistanche Extract Anti RadiationXya thiab 24 lub tebchaw nthuav tawm kev tiv thaiv kev laus hauv cov txiv hmab txiv ntoo yoov thiab C. elegans, raws li. 3,3'-thiodi propionic acid nrog kev tiv thaiv kev laus hauv Asplanchna Brightwell. Nees nkaum ib ntawm 35 lub tebchaw nthuav tawm cov haujlwm tiv thaiv oxidative.

Nyob rau hauv tag nrho, muaj 212 thiab 46 cov tebchaw uas nthuav tawm kev tiv thaiv kev laus hauv C. elegans thiab txiv hmab txiv ntoo ya, feem, qhia C.cistanche tshuaj ntsuabelegans thiab txiv hmab txiv ntoo ya yog cov qauv kev laus tshaj plaws rau kev tshuaj ntsuam xyuas kev laus. Cov tebchaw no nthuav tawm kev tiv thaiv kev laus hauv ob qho tib si C. elegans thiab txiv hmab txiv ntoo yoov yog tsim nyog los soj ntsuam ntxiv hauv cov qauv tsiaj txhu.

4 Cov Kev Pom Zoo ntawm Kev Tshawb Fawb Kev Tiv Thaiv Kev Laus Molecules los ntawm Cov Khoom Siv Ntuj

Ntau cov tshuaj kho mob tau muab los ntawm cov khoom ntuj tsim. Tab sis nyob rau hauv ob xyoos dhau los, cov tuam txhab tshuaj tau txaus siab rau txoj kev txhim kho tshuaj ntawm kev tshuaj ntsuam xyuas siab (HTS) thiab combinatorial synthesis ntawm cov tsev qiv ntawv hluavtaws loj ntawm cov khoom me me. Cov khoom ntuj tsim tau raug tsis saib xyuas ntau rau qhov tsis zoo rau HTS ntawm kev soj ntsuam cov protein thiab nyuaj hauv kev sib cais thiab kev sib txuas. Tab sis qhov ua tiav ntawm kev tshawb pom tshiab thiab kev pom zoo tshuaj tshiab tau poob siab [85]. Piv nrog cov khoom siv hluavtaws, cov khoom ntuj tsim yog cov metabolites theem nrab, evolutionarily optimized nrog cov tshuaj lom neeg muaj feem xyuam rau qhov chaw thiab nyiam ligand-binding motif, thiab tsis tsuas yog lom lom tab sis nrog rau qib siab ntawm bioavailability, haum rau kev ua haujlwm thiab phenotypic kev soj ntsuam [{{3} }]. Kev tsim kho tshiab tsis ntev los no hauv cov tswv yim rau kev tsim cov qauv tsim, metabolomics rau profiling thiab kev cais tawm, thiab metagenomics lossis gene manipulation rau cov txheej txheem hluavtaws tau yooj yim rau kev tshawb nrhiav cov biodiversity loj hauv ntiaj teb, suav nrog cov nroj tsuag, kab mob thiab cov kab mob marine [87]. Kev tsim khoom ntawm cov khoom ntuj tsim los ntawm cov tsiaj tsis zoo tuaj yeem nthuav dav cov tshuaj lom neeg ntawm cov khoom ntuj tsim los ntawm hluavtaws biology [88].

Ntxiv mus, niaj hnub siv computer-pab siv tshuaj tsim yuav siv tau tej yam ntuj tso-cov khoom-derived fragments los computationally infer lub biomolecular lub hom phiaj thiab kev ua ub no ntawm natural products thiab fragment-based de novo design. Raws li cov ntsiab lus saum toj no, tam sim no pom cov neeg ua haujlwm nrog kev tiv thaiv kev laus, feem ntau ntawm lawv yog cov khoom ntuj tsim.cistanche noov loj hlob,Yog li ntawd, tej yam ntuj tso khoom yog invaluable qhov chaw thiab muab kev cog lus zoo rau kev tsim tshuaj tiv thaiv kev laus. Kev lees paub Txoj haujlwm no tau txais kev txhawb nqa los ntawm Natural Science Foundation ntawm Tuam Tshoj (81671405 thiab 81370453), Natural Science Foundation ntawm Yunnan xeev (2013FA045 thiab 2015FB172), thiab Qhib Nyiaj Txiag ntawm Guangdong Key Laboratory ntawm Marine Materia Medica.

Kab lus no yog muab rho tawm los ntawm Nat. Prod. Bioprospect. (2017) 7:335–404DOI 10.1007/s13659-017-0135-9