Kev soj ntsuam soj ntsuam ntawm kev kho mob ntawm Infantile Enuresis Nrog Cistanche Granule

Chang Ke 1, Wang Junxia 2, Sun Zhijuan 2, Zhang Xiang 3

1. Affiliated Tsev Kho Mob ntawm Chengdu University of Traditional suav tshuaj, Chengdu 60072, Sichuan, Suav teb

2. Chengdu University of Traditional suav tshuaj, Chengdu 610075, Sichuan

3. Chengdu Jinniu District Tsev Kho Mob ntawm Tsob Ntoo Suav Tshuaj, Chengdu 610083, Sichuan, Suav

Hu rau:joanna.jia@wecistanche.com/ WhatsApp: 008618081934791

[Cov Lus Qhia] Lub Hom Phiaj: Txhawm rau saib xyuas qhov ua tau zoo ntawm kev kho mobcistancheGranules hauv kev kho cov menyuam yaus nrog enuresis thiab lub raum tsis txaus. Txoj Kev: Yim caum-ib tus neeg mob uas muaj lub raum tsis txaus hauv cov menyuam yaus uas muaj enuresis tau muab faib ua pawg kho mob thiab pawg tswj hwm ntawm qhov sib piv ntawm 3: 1. 60 tus neeg mob hauv pab pawg kho mob tau kho nrogcistanche granules, thiab 21 tus neeg mob hauv pawg tswj hwm tau kho nrog diclofenac hydrochloride capsules. Kev kho qhov ncauj. Tom qab 4 lub lis piam ntawm kev tswj hwm tas li, kev soj ntsuam kev ua tau zoo thiab kev ua tau zoo ntawm cov tshuaj suav tshuaj tau muab piv. Cov txiaj ntsig: Hauv pab pawg kho mob curative effect kho mob, 21 tus neeg mob tau kho mob, 29 tus neeg mob tau txais txiaj ntsig zoo, 2 kis tau zoo, thiab 8 tus neeg mob tsis tau txais txiaj ntsig. Tag nrho cov txiaj ntsig tau zoo yog 86.67 feem pua ​​. Hauv pawg tswj hwm, 4 kis tau kho kho mob, 7 kis tau zoo heev, 4 kis tau zoo, thiab 6 kis tsis tau zoo. Tag nrho cov txiaj ntsig tau zoo yog 71.43 feem pua. Muab piv rau kev kho mob ntawm ob pawg, qhov sib txawv yog qhov tseem ceeb (P<0.05). in="" the="" tcm="" treatment="" group,="" 22="" cases="" were="" cured,="" 28="" cases="" were="" markedly="" effective,="" 4="" cases="" were="" effective,="" and="" 6="" cases="" were="" ineffective.="" the="" total="" effective="" rate="" was="" 90.00%.="" in="" the="" control="" group,="" 4="" cases="" were="" cured,="" 7="" cases="" were="" markedly="" effective,="" 4="" cases="" were="" effective,="" and="" 6="" cases="" were="" ineffective.="" the="" total="" effective="" rate="" was="" 71.43%.="" the="" difference="" in="" medical="" efficacy="" between="" the="" two="" groups="" was="" significant="" (p=""><0.05). conclusion:="" the="">cistanchegranule muaj cov txiaj ntsig zoo hauv kev kho cov menyuam yaus uas muaj enuresis thiab lub raum tsis muaj zog.

[Cov ntsiab lus] Enuresis; Cov menyuam yaus; Tsoos suav tshuaj (TCM); cistanche granules, cistanche, cistanche deserticola, cistanche tubulosa, suab puam nyob cistanche

cistanche deserticola cov txiaj ntsig

Pediatric enuresis, tseem hu ua enuresis thiab bedwetting, hais txog cov kab mob uas cov menyuam yaus hnub nyoog qis dua 5 xyoos tso zis thaum pw tsaug zog thiab sawv thiab hnov ​​​​mob. Nws yog ib qho ntawm cov kab mob uas muaj ntau tshaj plaws thiab tsis meej pem hauv cov menyuam yaus [1]. Feem ntau ntawm cov kab mob yog raws li kev siv tshuaj, thiab nws kuj koom tes nrog kev qhia lub neej thiab kev kho mob puas siab puas ntsws. Kev nkag siab ntawm tus kab mob no nyob rau hauv cov tshuaj suav tshuaj yog hais tias lub ntsiab pathogenesis ntawm lub zais zis tsis muaj feem xyuam rau lub ntsiab pathogenesis ntawm cov nram qab no yog vim li cas xws li deficiency ntawm tus mob khaub thuas, insufficiency ntawm lub raum qi, tsis muaj peev xwm ntawm qi nyob rau hauv lub ntsws thiab spleen, thiab damp-heat nyob rau hauv daim siab meridian [1]Cov kev kho mob tseem ceeb yog ua kom sov lub raum thiab ua kom lub cev noj qab haus huv, noj zaub mov kom lub ntsws thiab ua kom lub plab mog, thiab tshem tawm cov cua sov thiab dampness.Tus sau txais yuavcistancheGranules txhawb lub raum, ua kom lub zais zis, thiab kho cov menyuam yaus uas muaj enuresis nrog raum tsis txaus. Cov txiaj ntsig tau tshaj tawm raws li hauv qab no.

1 cov ntaub ntawv kho mob

1.1 Diagnostic standards refer to "Practical Pediatrics" [2], "Pediatrics of Traditional Chinese Medicine" [1], "Cov Ntsiab Cai rau Kev Tshawb Fawb Txog Cov Tshuaj Tshiab Suav" [3] Cov txheej txheem kuaj mob muaj raws li hauv qab no. Western tshuaj ntsuam xyuas cov txheej txheem: cov menyuam yaus hnub nyoog qis dua 5 xyoos tsis tuaj yeem tswj lawv cov zis thaum hmo ntuj, feem ntau tso zis tsis hnov ​​​​tsw, tsis suav nrog cov kab mob urinary, malformations, pinworms, txha caj qaum raug mob, qaug dab peg, kev loj hlob ntawm lub hlwb.

Enuresis yog tshwm sim los ntawm qhov tsis txaus, ntshav qab zib mellitus, ntshav qab zib insipidus, thiab lwm yam Xiayuan Deficiency thiab txias (Kidney Deficiency Type) Syndrome Differentiation Standard: Cov tsos mob tseem ceeb: nquag enuresis thaum pw tsaug zog, feem ntau ob peb zaug ib hmos, sawv thiab sawv; Cov tsos mob thib ob: qaug zog, daj ntseg tawv nqaij, mob khaub thuas ntshai mob khaub thuas, tsis muaj zog ntawm cov ceg qis, mob duav thiab ob txhais ceg, tso zis ntshiab thiab ntev, nplaig txheej yog xim dawb, lub plawv dhia qeeb thiab tsis muaj zog. Nrog tsawg kawg 2 ntawm cov tsos mob tseem ceeb thiab cov tsos mob thib ob, nws tuaj yeem kuaj tau los ntawm kev xa mus rau tus nplaig thiab mem tes.

1.2 Cov txheej txheem suav nrog Ua tau raws li kev kuaj mob ntawm Western tshuaj; Ua tau raws li cov txheej txheem rau kev sib txawv ntawm lub raum tsis txaus hauv TCM; Qhov nruab nrab tus naj npawb ntawm hmo ntuj enuresis ib hlis yog ntau tshaj 15 zaug; hnub nyoog yog 5 txog 14 xyoos.

1.3 Cov txheej txheem cais tawm tsis ua raws li cov kev kuaj mob saum toj no thiab cov txheej txheem sib txawv ntawm tus mob; congenital sacral Bifida; enuresis tshwm sim los ntawm neurological, urinary, thiab endocrine system kab mob, xws li mob urinary ib ntsuj av tau kab mob, qaug dab peg, hlwb hypoplasia, ntshav qab zib, thiab lwm yam .; Cov kab mob tsis tuaj yeem siv los yog tus nqi ntawm cov khoom kuaj kuaj rau kev txhais cov mob ntawm cov kab mob sib xyaw ua ke tshaj tus qauv los ntawm ntau dua 20 feem pua ​​(cov leeg ntshav)

Anhydride (Cr) saum toj ib txwm txwv], thiab zis protein (ntxiv rau), ntshav liab (ntxiv) lossis siab dua; kev tsis haum lub cev (cov neeg ua xua rau cov tshuaj saum toj no qeb 2), lossis ua xua rau cov khoom ntawm qhov kev npaj no, siv tshuaj; raws li kws kho mob txiav txim, nws yog ib qho yooj yim ua rau poob ntawm kev soj ntsuam.

Cov ntaub ntawv dav dav 81 tus menyuam tau los ntawm lub chaw kho mob tshwj xeeb nephrology ntawm peb lub tsev kho mob txij lub Ib Hlis mus txog rau Lub Rau Hli 2011. Raws li lub hauv paus ntsiab lus ntawm randomization, lawv tau muab faib ua pawg kho mob ntawm 60 tus neeg mob thiab pab pawg tswj ntawm 21 tus neeg mob ntawm qhov sib piv ntawm 3: 1; hnub nyoog 5 txog 14 xyoo, nruab nrab (7.17 ± 1.23) xyoo. Cov ntaub ntawv dav dav ntawm ob pawg tau ua tiav, thiab qhov sib txawv tsis tseem ceeb (P ＞ 0.05), thiab lawv tau sib piv.

2 txoj kev kho mob

2.1 Pab pawg kho mob: cistanche Granules (tsim los ntawm Inner Mongolia Lantai Pharmaceutical Co., Ltd.): 5 mus rau 7 xyoo, 2 g txhua zaus, 2 zaug hauv ib hnub; 8 mus rau 14 xyoo, 2 g ib zaug, 3 zaug ib hnub twg. Siv nws li 4 lub lis piam.

2.2 Pawg tswj hwm tau noj meclofenamate hydrochloride capsules (Guangdong Xianqiang Pharmaceutical Co., Ltd., batch naj npawb: H44023391), 100 mg txhua zaus, ib hnub ib zaug, ib nrab teev ua ntej yuav mus pw, rau 4 lub lis piam.

Thaum lub sijhawm soj ntsuam hauv 2 pawg, lwm cov tshuaj suav thiab Western uas tuaj yeem kho cov menyuam yaus nrog enuresis raug txwv. Rau cov neeg mob khaub thuas, hnoos, raws plab, thiab lwm yam tsos mob thaum kho, cov tshuaj Western cov pa yuav tsum tau siv, tab sis lub sij hawm ntawm kev siv, lub npe tshuaj, ntau npaum li cas, thiab zaus ntawm kev siv yuav tsum tau muab sau rau ntawm lub rooj soj ntsuam kom cov ntsiab lus yuav tsum tau. qhia tseeb. Rau cov neeg uas tsis tau zoo tom qab kev kho mob, kev kho dua tshiab.

3 Kev soj ntsuam ntsuas thiab cov txheej txheem txheeb cais

3.1 Kev soj ntsuam cov tsos mob ntsig txog: thawj cov tsos mob: zaus ntawm enuresis, qhov tob ntawm kev pw tsaug zog; Cov tsos mob thib ob: tshwm sim los yog tsis tuaj yeem tso zis luv luv, xim ntshiab, kev ua haujlwm ib txwm muaj, tsis quav ntsej, thiab kev ua haujlwm tsis zoo. Tej yam tshwm sim: tus nplaig, mem tes. Raws li qib sib txawv ntawm cov tsos mob tseem ceeb, cov qhab nia thiab cov lej tuaj yeem tau txais.

3.2 Cov txheej txheem Kev Txheeb Xyuas Raws li ntau hom kev ntsuas cov ntaub ntawv, Wilcoxon kos npe-qib xeem ntawm cov qauv ua ke thiab ob-tus qauv Kolmogorov-Smirnov Test (Ob-Sample Kolmogorov-Smirnov Test) tau ua raws li cov ntaub ntawv ntsuas; χ2 xeem tau siv rau suav cov ntaub ntawv. Siv SPSS14.0 thiab Excel software rau kev txheeb cais.

4 Cov qauv kev ua tau zoo thiab cov txiaj ntsig kev kho mob

Cov txheej txheem kev ua tau zoo ntawm kev kho mob tau kos nrog kev siv rau "Kev Ntsuas Kev Ntsuas rau Cov Kab Mob Me" [4]. Kev kho mob rov qab: tsis muaj enuresis ntxiv thaum hmo ntuj tom qab kev kho mob, thiab cov kev soj ntsuam tseem ceeb tau txhim kho. Cov nyhuv tseem ceeb: Tom qab kev kho mob, qhov zaus ntawm hmo ntuj enuresis raug txo los ntawm ntau dua 50 feem pua, lossis cov tsos mob tseem ceeb tau txo qis dua 60 feem pua, thiab feem ntau ntawm cov kev soj ntsuam tseem ceeb tau txhim kho (ntau dua 2/3 kev txhim kho). Siv tau: Tom qab kev kho mob, tus naj npawb ntawm hmo ntuj enuresis raug txo qis tab sis tsawg dua 50 feem pua ​​​​lossis cov tsos mob tseem ceeb tau qhab nia thiab txo los ntawm 30 feem pua ​​​​rau 60 feem pua ​​​​, thiab cov kev soj ntsuam tseem ceeb yog ib feem ntawm kev txhim kho (ntau dua 1/2 kev txhim kho). Ineffective: Qhov zaus ntawm hmo ntuj enuresis ua ntej thiab tom qab kev kho mob tsis zoo, thiab cov kev soj ntsuam tseem ceeb tsis zoo. Tus naj npawb ntawm enuresis ua ntej kev kho mob yog hais txog tus naj npawb ntawm enuresis ib lub lis piam ua ntej kev kho mob, thiab tus naj npawb ntawm enuresis tom qab kev kho mob yog hais txog tus naj npawb ntawm enuresis ib lub lim tiam ua ntej 4th rov qab mus ntsib.

4.1 TCM cov qauv kev ua tau zoo Xa mus rau "Cov Cai Qhia Txog Kev Tshawb Fawb Txog Cov Tshuaj Tshiab Suav" [3]. Rov qab: Tau qhab nia thiab txo qis dua 95 feem pua. Ua tau zoo heev: tau qhab nia thiab txo 60 feem pua ​​​​rau 94 feem pua. Zoo: tau qhab nia thiab txo 30 feem pua ​​​​rau 59 feem pua. Invalid: qhab nia thiab txo qis dua 30 feem pua.

4.2 Kev sib piv ntawm kev soj ntsuam kev ua tau zoo hauv 32 pawg Hauv pawg kho mob, 21 tus neeg mob tau kho, 29 tus neeg mob tau txais txiaj ntsig zoo, 2 tus neeg tau txais txiaj ntsig, thiab 8 tus neeg mob tsis zoo. Tag nrho cov txiaj ntsig tau zoo yog 86.67 feem pua ​​. Hauv pawg tswj hwm, 4 kis tau kho mob, 7 kis tau zoo heev, 4 kis tau zoo, thiab 6 kis tsis tau zoo. Tag nrho cov txiaj ntsig tau zoo yog 71.43 feem pua. Muab piv cov kev kho mob ua tau zoo ntawm ob pawg, qhov sib txawv yog qhov tseem ceeb (P<0.05, χ2="7.8890," p="">

4.3 Kev sib piv ntawm cov txiaj ntsig kev kho mob hauv pab pawg kho mob 22 tus neeg tau kho, 28 tus neeg tau txais txiaj ntsig zoo, 4 tus neeg tau txais txiaj ntsig, thiab 6 tus neeg mob tsis zoo hauv pab pawg kho mob. Tag nrho cov txiaj ntsig tau zoo yog 90.00 feem pua ​​. Hauv pawg tswj hwm, 4 kis tau kho, 7 kis tau zoo heev, 4 kis tau zoo, thiab 6 kis tsis tau. Tag nrho cov txiaj ntsig tau zoo yog 71.43 feem pua. Muab piv rau kev kho mob ntawm ob pawg, qhov sib txawv yog qhov tseem ceeb (P<0.05, χ2="8.5481," p="">

5 kev sib tham

5.1 Xaiv Cov Tshuaj Tswj Zoo

Muaj peb lub hauv paus ntsiab lus rau kev tsim cov tshuaj tswj tau zoo: cov tshuaj pom zoo nrog cov lej batch; Cov tshuaj tswj tau zoo thiab cov tshuaj tshawb fawb zoo sib xws hauv kev ua tau zoo thiab kev qhia, thiab txoj kev kho mob ntawm kev tswj hwm yog tib yam. Clofenoxate Hydrochloride Capsules yog ib qho tshuaj uas muaj tus lej batch uas tsim los ntawm Guangdong Xianqiang Pharmaceutical Co., Ltd. Cov txiaj ntsig ntawm nws cov tshuaj pharmacological thaum ntxov qhia tau hais tias cov khoom no tuaj yeem txhawb nqa lub redox metabolism hauv hlwb hlwb, nce kev siv cov ntshav qab zib thiab oxygen, tuaj yeem tswj cov metabolism hauv paj hlwb, ua kom cov hlab ntsha tsis kam, thiab muaj txiaj ntsig zoo rau inhibited central cell. , Thiab tuaj yeem siv rau hauv cov xwm txheej uas kev nco thiab kev xav tau cuam tshuam. Cov txiaj ntsig ntawm pharmacodynamic yav dhau los tau pom tias cov khoom no tuaj yeem txo qis cov zis hauv cov nas ib txwm muab cov dej ntim, tuaj yeem txo cov zis tso zis ntawm cov nas, thiab muaj txiaj ntsig zoo rau cov luav lub zais zis detrusor. Nyob rau tib lub sijhawm, ob qho tib si Clofenoxate Hydrochloride Capsules thiab cistanche Granules yog siv los ntawm qhov ncauj, uas ua raws li lub hauv paus ntsiab lus ntawm kev tsim cov tshuaj tswj tau zoo, thiab lawv sib piv hauv kev kho mob.

5.2 Kev tshuaj xyuas cov nyhuv curative ntawm cistanche Granules

Qhov no yog ib txwm suav tshuaj txoj kev kho kom raug. Piv txwv li, "Suwen · Pulse to Subtle Theory": "Yog tias muaj ntau tshaj ib lub caij nplooj ntoos hlav, lub zais zis tsis zais nws." "Suwen · Xuanming Tsib Qi": "Nws tsis yog hais txog kev poob dej." "Rau cov neeg uas muaj enuresis, lub zais zis tsis txaus thiab txias, uas tsis tuaj yeem tshwm sim los ntawm dej. Lub zais zis yog lub hnub, lub raum yog ko taw Shao-yin, thiab lub thib ob meridian yog sab nrauv thiab sab hauv. Yu Ye. Lub tsev ntawm cov kua dej hauv lub cev, lub tsev txias thiab tsis muaj zog, thiab lub zog yang tsis muaj zog, nws tsis tuaj yeem tuav hauv dej, yog li enuresis. " Txoj cai.

"Taiping Shenghui Cov Tshuaj · Cov Tshuaj Kho Mob Enuresis" kom meej meej tso rau pem hauv ntej txoj kev "kev kho mob ntawm enuresis thiab astringency tas li". cistanche Granules nourishes lub raum, siv Cistanche ua vaj ntxwv, sov lub yang, thiab nourishes lub raum los kho lub deficiency thiab txias ntawm lub primordial keeb; Cuscuta thiab Morinda citrifolia yog cov thawj coj, pab lub raum, thiab txhawb cov yang nrog lub zog ntawm cov tshuaj muaj zog huab tais los txhawb lub raum; Schisandra yog qaub thiab astringent, thiab Poria cocos, Plantago Noob yog maj mam permeable thiab diuresis dej, ib tug sau thiab ib qho txiaj ntsim, qhib thiab kaw muaj ib tug degree, solidification zog, ob qho tib si raws li adjuvants. Kev siv ua ke ntawm tag nrho cov tshuaj muaj txiaj ntsig ntawm kev ua kom sov yang ua kom lub raum ua kom lub raum, ua kom lub raum, thiab kho tag nrho cov kab mob enuresis tshwm sim los ntawm lub raum tsis txaus qi thiab lub zais zis txias. Nws muaj cov teebmeem tseeb thiab cov teebmeem me me. Nws yog Suav patent tshuaj rau kev kho mob ntawm pediatric enuresis los ntawm cov kws kho mob hauv tsev kho mob. Lwm qhov kev xaiv.

cov ntaub ntawv

[1] Su Shurong. Pediatrics ntawm Suav Tshuaj [M]. Beijing: People's Medical Publishing House, 2003: 112.

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[3] Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv ntawm Tib Neeg Lub Tebchaws Suav. Cov Ntsiab Lus Qhia Txog Kev Tshawb Fawb Txog Tshuaj Kho Mob Tshiab Suav: Thib Peb [S]. Xyoo 1997.

[4] Li Li. Cov txheej txheem kuaj mob rau menyuam yaus [M]. Beijing: Science Xovxwm, 2001: 247.