Hu rau: jerry.he@wecistanche.com

Cistanche tuaj yeem txhim kho lub raum ua haujlwm

José Medina-Pestana, PhD, 1 Marina Pontello Cristelli, PhD, 1 Laila Almeida Viana, MD, 1Renato Demarchi Foresto, MD, 1 Lucio R. Requião-Moura, PhD, 1 Helio Tedesco-Silva, PhD, 1 thiab Dimas Tadeu Covas , PhD 2, 3

n theem 3 sim, inactivated mob hnyav ua pa syndromekhaus laus nas vais lav2 (SARS-CoV-2) vaccine (CoronaVac, Sinovac Life Sciences, Beijing, Tuam Tshoj) tau cuam tshuam nrog 71.1 feem pua ​​​​seroconversion tsawg kawg yog 14 d tom qab koob thib ob, qhia txog 50.7 feem pua ​​​​kev ua tau zoo tiv thaiv cov tsos mob COVID-19 ntawm cov neeg ua haujlwm kho mob.' Tam sim no, cov tshuaj tiv thaiv no tau pom zoo siv thaum muaj xwm txheej ceev hauv 24 lub tebchaws, suav nrog Brazil, qhov chaw txhaj tshuaj tiv thaiv hauv tebchaws tau pib thaum Lub Ib Hlis 1, 2021, ua raws li cov hnub nyoog.

Lub raumCov neeg tau txais kev hloov pauv tau pom tias 20 feem pua ​​​​ntawm -30 feem pua ​​​​COV-19-cov neeg tuag muaj feem cuam tshuam,' tau raug cais tawm hauv kev sim tshuaj tiv thaiv, thiab tsis muaj qhov tseem ceeb tshaj plaws rau kev txhaj tshuaj tiv thaiv. Yog li ntawd, qhov no ib leeg-chaw, yav tom ntej,12-mo kev tshawb nrhiav tau tsim los ntsuas qhov cuam tshuam rau kev kho mob,reactogenicity, thiabimmunogenicityntawmCoronaVac.

Between March 20 and 28,2021,3354 patients aged 30-69y,>30dof kev hloov pauv, thiab tsis muaj COVID yav dhau los-19 tau txais tus qauv 2- lub sijhawm koob tshuaj ntawmCoronaVac(3 ug ib koob, 28 d sib nrug). Cov neeg mob tau teem sijhawm kom tau txais cov tshuaj tiv thaiv ntawm 2 lub lis piam sib law liag, nrog kwv yees li 800-900 cov neeg mob ib d, txij li 7 teev sawv ntxov txog 7 teev tsaus ntuj Tag nrho cov kev sib txuas lus tau siv los mus cuag lawv li ntawm 3wk ua ntej hnub txhaj tshuaj tiv thaiv (xws li xov tooj, SMS ntawv, WhatsApp lus ). Cov chaw ua haujlwm tau teeb tsa ntawm lub tsev kho mob sab nraud thiab cov neeg mob tau txais hauv pab pawg ntawm 30 tus neeg kom (1) tau txais cov ntaub ntawv dav dav txog COVID-19, kev tshawb fawb soj ntsuam, tshuaj tiv thaiv, thiab kev tiv thaiv

measures;(2)inform consent discussion and signature;(3)registration of the patient in the electronic medical records of the institution;(4) blood sampling for serology followed by vaccination, and a reminder of the scheduled second dose. All employees of the institution were invited to participate in the vaccination campaign, and>300 tus kws tshaj lij tau tuaj yeem pab dawb rau cov haujlwm, suav nrog cov tub ntxhais kawm los ntawm ntau lub tebchaws.

Txoj kev tshawb no tau pom zoo los ntawm Pawg Neeg Saib Xyuas Kev Ncaj Ncees hauv zos, sau npe ntawm ClinicalTrials.gov, NCT04801667, thiab txhua tus neeg mob tau kos npe rau daim ntawv pom zoo. Hnub tim 28, tau txais daim ntawv nug tshwj xeeb los ntes cov kev tsis zoo rau cov tshuaj tiv thaiv lossis tau kuaj pom tus kab mob SARS-CoV-2 tshiab. Tus qauv loj rau lubimmunogenicitycohort (942 tus neeg mob seronegative rauimmunoglobulin [Ig]G anti-SARS-CoV-2 before the first dose)was calculated using the age distribution and seroconversion rate (71%)of the phase 3 study,' with a 95% confidence interval and an absolute error of 10%. Antibody response at day 28 was assessed using the AdviseDx SARS-CoV-2 IgG II assay (Abbot Laboratories, IL). Values >50 AU / ml tau suav tias yog qhov zoo. "

Cov yam ntxwv thiab cov txiaj ntsig ntawm cov neeg kawm (n{{0}}}) yog nyob rau hauv Table 1. Cov neeg mob feem ntau yog txiv neej, hnub nyoog nruab nrab ntawm 52 (interquartile range [IQR], 44-60)y, qis Feem ntau ntawm ntshav qab zib mellitus, thiab lub sijhawm nruab nrab ntawm kev hloov pauv ntawm 7 (IQR, 3-12) y. Seroprevalence ntawm IgG anti-SARS-CoV-2 nucleocapsid protein ntawm D0 yog 3.6 feem pua, thiab cov neeg mob seropositive thaum lub sijhawm txhaj tshuaj tiv thaiv tsis suav nrog rau kev tshuaj xyuas cov tshuaj tiv thaiv kab mob. Ntawm cov neeg mob seronegative ntawm D0, muaj 1012 tus neeg raug xaiv los xaiv rauimmunogenicitytsom xam. Lwm tus neeg mob tsis muaj kev sim ua tom qab txhaj tshuaj tiv thaiv. Tom qab thawj koob tshuaj tiv thaiv, 61 (1.8 feem pua) cov neeg mob tau COVID-19 tau lees paub los ntawm kev rov qab hloov pauv-polymerase saw cov tshuaj tiv thaiv lossis tshuaj tiv thaiv antigen ntawm lub sijhawm nruab nrab ntawm 12 (IQR, 8-16) d. Ntawm lawv, 44 (72 feem pua) yuav tsum tau mus pw hauv tsev kho mob, thiab 16 (26 feem pua) tuag 14-49 d tom qab thawj koob tshuaj tiv thaiv.

Cistanche tuaj yeem txhim kho lub raum ua haujlwm

Qhov tshwm sim tsis zoo tshaj plaws yog qhov mob hauv zos / kev sib tw (11 feem pua). Cov tsos mob tshwm sim hauv 5 feem pua ​​lossis tsawg dua ntawm cov neeg mob; tsis muaj qhov tshwm sim tsis zoo tshwm sim. Tsuas muaj 1 ntu ntawm kev tsis lees paub cellular (Banff IB) 6 d tom qab txhaj tshuaj tiv thaiv hauv tus neeg mob nrog cov ntaub ntawv tsis muaj kev tiv thaiv uas pom tau tias rov ua haujlwm ib nrab ntawm lub raum ua haujlwm tom qab kho nrog methylprednisone thiab antipathy-monocyte globulin.

Seroconversion 28 d after the first dose was 15.2% (95% confidence interval, 12.9%-17.5%), with median IgG value of 477 AU/mL (IQR, 123–1705). Patients aged >60 xyoo los yog cov uas underwent ua keraum- pancreas hloov pauv tau qis dua seroconversion dua li cov laus<60 y="" and="" underwent="" isolated="" kidney="">

Lub peev xwm kom zoo dua ntawm cov tshuaj tiv thaiv kab mob ib txwm muaj, qhov induction ntawm polyclonal davtiv thaiv kab mobteb,4 tsis cuam tshuam nrog tus nqi seroconversion ntau dua piv nrog cov tshuaj tiv thaiv tshiab RNA-raws li COVID- 19.5 Hauv qhov kev tshawb nrhiav txuas ntxiv no, tsis muaj qhov cuam tshuam rau kev kho mob tom qab thawj koob tshuaj, raws li kev tsim tawm tsis tau tso cai ntawm tsab xov xwm no. txwv tsis pub.

ua qauv qhia los ntawm 26 feem pua ​​​​ua rau tuag taus, zoo ib yam li qhov tsis tau txhaj tshuajraumcov neeg txais kev hloov pauv.2CoronaVacCov tshuaj tiv thaiv muaj kev nyab xeeb, tab sis seroconversion tom qab thawj koob tshuaj tsawg, zoo ib yam li qhov tau tshaj tawm rau cov tshuaj tiv thaiv RNA. Cov neeg laus pom txawm tias qis dua ntawm seroconversion. Cov kev tshawb pom no txhawb nqa qhov xav tau los tswj kev tiv thaiv tus kheej, txawm tias tom qab thawj koob tshuaj tiv thaiv.

Cistanche tuaj yeem txhim kho lub raum ua haujlwm

TXOJ CAI

Txoj haujlwm no yuav ua tsis tau yog tias tsis muaj cov tshuaj tiv thaiv, koom tes los ntawm Ricardo Palacios, MD, Ph.D., thiab Roberta Piorelli, MD, los ntawm Instituto Butantan, kev ua haujlwm pub dawb ntawm yuav luag 300 tus tub ntxhais kawm thiab cov kws tshaj lij ntawm Tsev Kho Mob ua Rim thiab lwm lub tsev kho mob hauv São Paulo thaum txhaj tshuaj tiv thaiv, thiab qhov muaj txiaj ntsig zoo ntawm peb tus kws kho mob biochemist Elizabeth França Lucena, BA, uas tau ua txhua qhov kev soj ntsuam hauv chav kuaj.