Clinical And Biomarker Profile Teb Lus Teb Rau Kev Kho Mob Kho Mob Hauv Cov Neeg Mob Nrog Ntev COVID Characterized Los Ntawm Kev Nyuaj Siab Part 2

3.3. Teb rau Kev Kho Mob

Thaum peb soj ntsuam cov lus teb rau kev kho mob, peb pom tsis muaj qhov sib txawv tseem ceeb hauv Borg nplai rau dyspnea lossis FIS rau qaug zog ua ntej thiab tom qab tau txais kev kho mob rov qab. Txawm li cas los xij, hais txog 6 MWT, peb pom qhov kev txhim kho tseem ceeb hauv cov meters taug kev ua ntej thiab tom qab kev cuam tshuam kev kho mob. Ntxiv mus, peb pom kev ruaj ntseg hauv feem pua ​​​​ntawm cov meters taug kev (Table 4).

Cistanche tuaj yeem ua raws li kev tiv thaiv kev qaug zog thiab lub zog ua kom muaj zog, thiab cov kev tshawb fawb sim tau pom tias decoction ntawm Cistanche tubulosa tuaj yeem tiv thaiv daim siab hepatocytes thiab endothelial hlwb puas hauv cov nas ua luam dej hnyav, txhawb kev qhia ntawm NOS3, thiab txhawb cov kab mob siab glycogen. synthesis, yog li exerting los tiv thaiv qaug zog. Phenylethanoid glycoside-nplua nuj Cistanche tubulosa extract tuaj yeem txo cov ntshav creatine kinase, lactate dehydrogenase, thiab lactate qib, thiab nce qib hemoglobin (HB) thiab piam thaj hauv ICR nas, thiab qhov no tuaj yeem ua lub luag haujlwm tiv thaiv kev qaug zog los ntawm kev txo qis cov leeg nqaij. thiab ncua lub lactic acid enrichment rau lub zog cia hauv nas. Compound Cistanche Tubulosa ntsiav tshuaj ua rau lub sijhawm ua luam dej hnyav, nce siab glycogen cia, thiab txo qis qib urea tom qab kev tawm dag zog hauv cov nas, qhia nws cov nyhuv tiv thaiv kev qaug zog. Lub decoction ntawm Cistanchis tuaj yeem txhim kho kev ua siab ntev thiab ua kom lub cev qaug zog hauv kev tawm dag zog nas, thiab tuaj yeem txo qhov siab ntawm cov ntshav creatine kinase tom qab kev tawm dag zog thiab ua kom lub cev nqaij daim tawv nqaij ntawm cov nas ib txwm muaj tom qab kev tawm dag zog, uas qhia tau hais tias nws muaj cov teebmeem. ntawm kev txhim kho lub cev muaj zog thiab tiv thaiv qaug zog. Cistanchis kuj tseem ua rau lub sijhawm muaj sia nyob ntawm cov nas uas muaj nitrite-poisoned thiab txhim kho lub siab ntev tiv thaiv hypoxia thiab qaug zog.

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SBP tau qis dua qhov kev sim thawj zaug. Lwm qhov kev hloov pauv tsis tau qhia qhov sib txawv tseem ceeb.

Thaum kawg, thaum kawg ntawm kev kho kom rov zoo, los ntawm kev hu xov tooj, kev qaug zog thiab kev txaus siab tau sau. Qhov cuam tshuam qhov qaug zog tau nthuav tawm qhov qhab nia nruab nrab ntawm 22.14 (4.90) (tawm ntawm 32), thiab cov neeg koom tau muab qhov qhab nia nruab nrab ntawm 8.36 (1.50) tawm ntawm 10 rau lawv txoj kev txaus siab rau txoj kev kawm.

3.4. Cov yam ntxwv sib txawv ntawm cov neeg mob "Tebchaws" thiab "Nonresponders" cov neeg mob

Tom qab kev kho kom rov zoo, peb tau faib cov neeg mob raws li kev txhim kho hauv kev taug kev meters raws li "tus neeg teb" thiab "tsis teb", thiab peb piv cov yam ntxwv tseem ceeb ntawm ob pawg. Peb tsis tau soj ntsuam qhov sib txawv ntawm cov ntaub ntawv kho mob tau sau tseg (hnub nyoog, kev ua xua, comorbidities, theem ntawm lub cev ua haujlwm, tus yam ntxwv ntawm tus mob COVID-19, tshuaj tiv thaiv, kuaj lub cev, BMI, HAD Scale, lossis LC cov tsos mob) ntawm cov pab pawg ("cov neeg teb" thiab "tsis teb"). Hais txog kev soj ntsuam ntshav thov hauv kev sab laj, "cov neeg teb" muaj cov qib creatinine ntau dua li "cov neeg tsis teb" (Table 5) thiab kuj muaj qhov qis dua ntawm cov protein / creatinine (Daim duab 3). Txawm hais tias cov protein ntau tsis sib txawv ntawm "cov neeg teb" thiab "cov neeg tsis teb", feem ntau yuav yog vim cov qauv me me, zoo li muaj qhov sib txawv rau "cov neeg teb" los nthuav qhia ntau dua. Tom qab ntawd, peb tau tsim cov qauv logistic regression siv qhov piv ntawm cov proteins / creatinine thiab peb tau txais tias yog tias qhov piv txwv no loj dua 10, peb muaj qhov tseeb ntawm 78%, nrog rau kev nkag siab ntawm 0. 75 thiab qhov tshwj xeeb ntawm 0.8. Lwm qhov kev txheeb xyuas qhov sib txawv uas tau sau tseg tsis qhia qhov sib txawv tseem ceeb.

Tom qab ntawd, peb kuj tau txheeb xyuas cov lus teb rau kev kho mob txog kev muaj rog thiab lub xeev txhaj tshuaj tiv thaiv.

3.4.1. Lub cev Mass Index

We classified patients according to their BMI. Subjects with obesity (>30 Kg/m2 ) muaj qhov zaus siab dua ntawm cov tsos mob hnyav uas yuav tsum tau txais kev tso npe (66.7% vs. 0.0% hauv cov neeg mob tsis rog, p=0.015). Hais txog qhov tseem ceeb los ntawm RHBC, cov neeg mob rog rog tau nthuav tawm qhov tsawg dua ntawm cov meters taug kev hauv 6MWT ua ntej kho dua li cov neeg mob tsis rog (meters hauv cov neeg mob tsis rog: 461.75 ± 46.80 vs. meters hauv cov neeg mob rog: 384.20 ± 44.30, p.=0.015), qis Borg kawg dyspnea qhab nia (cov neeg mob uas tsis muaj ntshav qab zib: 6.50 ± 1.40 vs. cov neeg mob rog rog: 3.33 ± 1.10, p=0.016) thiab qis FIS kawg rau qaug zog (nonobesity: 7.50 (7.00–8.50) vs. cov neeg mob rog: 4.00 (4.00), p=0.048). Hais txog qhov ntsuas qhov ntsuas, cov neeg mob uas muaj rog rog muaj qib ALT ntau dua (cov neeg mob uas tsis rog: 14.50 (13. }}–50.50), p=0.045) thiab GGT (nonobesity: 11.50 (9.25–13.00) vs. rog: 46.00 (27.50–71.{{ 66}}), p=0.002) dua li cov neeg mob tsis rog. Tsis muaj qhov sib txawv tseem ceeb tau pom txog qib ntawm kev ua si lub cev lossis HAD qhov qhab nia.

3.4.2. Kev txhaj tshuaj

Tag nrho ntawm 78% ntawm cov neeg koom tau txais thawj koob tshuaj tiv thaiv SARS-CoV-2, nrog rau feem coob tau txais cov tshuaj tiv thaiv Pfizer (42.9%). Tag nrho ntawm 28.6% ntawm cov neeg mob tau txais koob thib ob, nrog rau feem ntau tau txais cov tshuaj tiv thaiv Pfizer (78%). Txhua yam kev txhaj tshuaj tau txhaj tshuaj txij lub Ib Hlis 15, 2021 txog rau Lub Yim Hli 25, 2021, txhawm rau saib xyuas qhov tseem ceeb ntawm txoj kev kho no. Txuas kev txhaj tshuaj tiv thaiv nrog COVID-19 qhov hnyav, 27.3% ntawm cov tshuaj tiv thaiv thiab 33.3% ntawm cov neeg mob tsis tau txhaj tshuaj pom cov tsos mob hnyav thiab yuav tsum tau mus pw hauv tsev kho mob. Thaum cov neeg mob txhaj tshuaj thawj zaug tsis muaj qhov sib txawv tseem ceeb ntawm cov txiaj ntsig tau txais hauv RHBC, cov neeg mob tau txhaj tshuaj thib ob tau nthuav tawm qhov sib txawv tseem ceeb hauv qhov kawg ntawm Borg / FIS tus nqi (tsis tau txhaj tshuaj: 7.50 (7.{{20 }}–8.50) vs. txhaj tshuaj tiv thaiv: 4.00 (4.00), p=0.048), ua rau cov neeg mob tsis tau txhaj tshuaj ntau dua li cov neeg mob txhaj tshuaj.

4. Kev sib tham

Ntev COVID Syndrome yog cov tsos mob ntawm ntau yam kab mob uas tshwm sim tom qab tus kab mob COVID-19 mob hnyav thiab tseem nyob dhau 12 lub lis piam tom qab kis kab mob. Ib qho ntawm cov tsos mob feem ntau cuam tshuam nrog kev cuam tshuam loj tshaj plaws ntawm kev ua neej zoo ntawm cov neeg mob yog qaug zog. Txawm hais tias ua mob rau lub neej thiab kev ua haujlwm ntawm cov neeg mob, tsis muaj kev kho tshwj xeeb rau cov kab mob no, yog li tam sim no txoj hauv kev pom zoo rau kev tswj tus neeg mob. Yog li ntawd, kev tshawb xyuas ntawm cov kab mob pathology no thiab nws cov kev kho mob tau zoo yog qhov tseem ceeb. Nyob rau hauv txoj kev tshawb no, lub luag hauj lwm uas ib tug multidisciplinary rehabilitation kev pab cuam yuav ua si nyob rau hauv kev kho mob ntawm LC cov neeg mob raug kuaj. Ntxiv mus, peb xav hais tias txawm hais tias qee tus kws sau ntawv tau kawm txog kev kwv yees ntawm LC tsos [14,21], tsis muaj kev tshawb fawb txog biomarkers ntawm cov lus teb rau kev kho mob, uas yuav muaj txiaj ntsig zoo hauv kev txiav txim siab zoo tshaj plaws rau kev kho mob. Vim li no, peb lub hom phiaj thib ob yog txhawm rau tshawb xyuas qhov muaj peev xwm ntawm biomarkers ntawm cov lus teb rau kev kho mob rov qab rau cov neeg mob no.

Hauv qhov kev nkag siab no, qhov tshiab ntawm txoj kev tshawb fawb tam sim no nyob hauv qhov tseeb tias peb tau siv qhov kev saib xyuas kev tawm dag zog zoo ib yam li tau piav qhia los ntawm Cattadori li al. [28] thiab kawm thawj zaug txog qhov muaj peev xwm ntawm kev kwv yees cov lus teb rau qhov kev kho mob rov qab no hauv cov neeg mob uas muaj LC syndrome thiab qaug zog ntev siv cov chaw sim, proinflammatory, thiab autoimmune biomarkers.

Ua ntej, nws yuav tsum tau muab sau tseg tias cov yam ntxwv hauv paus ntawm peb pawg neeg tau ua raws li kev pheej hmoo siab ntawm kev tsim LC uas tau piav qhia hauv cov ntaub ntawv, xws li hnub nyoog nruab nrab, rog rog, thiab poj niam txiv neej [3]. Nws paub tias qhov tshwm sim ntawm LC yog cuam tshuam los ntawm cov xwm txheej, xws li poj niam txiv neej pw, kev laus, qhov hnyav ntawm COVID-19 kab mob, lossis muaj qhov sib txawv ntawm SARS-CoV-2 variants [29,30] . Tag nrho ntawm 64.3% ntawm cov neeg mob muaj tus mob COVID-19 mob me me / nruab nrab qhov hnyav, thiab cov seem 35.7% raug mob hnyav uas yuav tsum tau mus pw hauv tsev kho mob, nrog rau kev xav tau hloov pauv [31,32] hauv kev tshuaj xyuas nkag ( nce qib siab tshaj AST, ALT, CRP, D-dimer, thiab IL -6 cov nqi siv). Qhov txhais tau tias LC cov tsos mob thiab lawv qhov kev faib tawm yog zoo ib yam li cov kev tshawb fawb hauv lwm cov kev tshawb fawb [8,19,22,33], feem ntau qhia txog qaug zog, mob taub hau, ua tsis taus pa, amnesia, thiab olfactory cuam tshuam. Hauv kev soj ntsuam hauv chav kuaj, cov neeg mob tau nthuav tawm qhov txawv txav siab txhais tau tias fibrinogen (445.80 (57.90)) thiab GSR (14.92 (8.40)), raws li kev txheeb xyuas cov ntaub ntawv cuam tshuam nrog LC pom hauv lwm cov kev tshawb fawb [34].

Tom qab kev kho kom rov zoo, cov neeg koom tau nthuav tawm qhov kev txhim kho tseem ceeb hauv cov meters taug kev thiab hauv cov pa oxygen saturation thiab SBP, nrog kev ruaj ntseg ntawm feem pua ​​​​ntawm cov meters taug kev thiab hauv Borg / FIS nplai. Ua ke, peb tuaj yeem txiav txim siab tias cov neeg mob hauv peb pawg neeg tau nthuav tawm cov lus teb ib nrab rau kev kho kom rov zoo. Cov txiaj ntsig hais txog kev txhim kho hauv meters taug kev zoo ib yam li lwm cov kev tshawb fawb [35,36]. Txawm li cas los xij, lwm tus kws sau ntawv tau pom tias muaj kev txhim kho hauv Borg / FIS qhov qhab nia tom qab kev kho mob rov qab los [35]. Peb cov txiaj ntsig tuaj yeem cuam tshuam los ntawm cov neeg mob tsawg vim tias nws yog kev sim ua haujlwm. Hais txog kev kho kom rov zoo li qub, nws yog ib qho tseem ceeb uas yuav tsum tau hais qhia tias kev tawm dag zog nruab nrab zoo li txhim kho lub cev tiv thaiv kab mob, yog li, nws yuav tsum raug pom zoo raws li txoj hauv kev tsis yog tshuaj tshuaj los tiv thaiv tus kab mob COVID-19 [37].

Hais txog kev rog rog, cov neeg mob rog rog tau nthuav tawm qhov tsawg dua ntawm cov meters taug kev hauv 6MWT ua ntej kev kho mob dua li cov neeg mob tsis rog, raws li xav tau. Txawm li cas los xij, cov neeg uas rog rog tau nthuav tawm qhov kev xav ntawm kev qaug zog lossis ua tsis taus pa tom qab kho. Qhov no tuaj yeem yog vim qhov tsis txaus ntseeg ntawm qhov kev xav no hauv cov neeg mob rog, tej zaum yuav ua rau muaj qee yam ua tsis taus pa [38].

Hais txog lub xeev txhaj tshuaj, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias kev txhaj tshuaj tiv thaiv muaj peev xwm txo tau qhov kev pheej hmoo ntawm LC [39]. Hauv peb txoj kev tshawb fawb, cov neeg mob tau txhaj tshuaj thib ob tiv thaiv SARS-CoV-2 piv rau cov neeg mob uas tsis muaj tshuaj tiv thaiv tau nthuav tawm qhov kev xav tsis zoo ntawm kev qaug zog. Hauv qhov kev nkag siab no, qee tus kws sau ntawv tau hais tias cov tshuaj tiv thaiv tuaj yeem txhim kho LC cov tsos mob los ntawm kev ua kom T-lymphocytes thiab tshem tawm cov kab mob hauv lub cev, ua rau muaj kev tiv thaiv kab mob, lossis cuam tshuam qhov tsis tsim nyog autoimmune teb tam sim no hauv LC [40].

Qhov qis qis ntawm creatinine tau pom nyob rau hauv "nonresponders" dua li "responder" cov neeg mob. Ntxiv mus, albumin thiab protein ntau kuj tseem qis dua hauv "tsis teb", thaum globulin qib siab dua, txawm tias tsis muaj qhov tseem ceeb ntawm cov ntaub ntawv. Qhov tsis muaj qhov tseem ceeb no yuav yog vim tus qauv me me. Nws yuav tsum raug sau tseg tias tag nrho cov txiaj ntsig (qib ntawm creatinine, protein, albumin, thiab globulin) nyob rau hauv ib txwm muaj. Zuag qhia tag nrho, cov ntaub ntawv no zoo li qhia tau hais tias cov neeg mob uas muaj cov khoom noj muaj protein ntau zoo yuav nthuav tawm cov lus teb zoo dua rau kev kho mob, raws li tau piav qhia [41]. Ntxiv mus, qee qhov kev tshawb fawb [42,43] tau txuas cov qib albumin siab dua thiab qib globulin qis dua nrog kev pom zoo rau COVID-19. Cov kev tshawb fawb ntxiv yuav tsum tau lees paub qhov kev soj ntsuam no. Tsis tas li ntawd, nws ua rau peb xav tias tej zaum cov kev txwv no tuaj yeem kwv yees cov lus teb rau kev kho mob rov qab. Hauv qhov kev nkag siab no, peb tau kawm txog kev sib raug zoo ntawm cov kev ntsuas sib txawv uas tau txais thawj hnub ntawm LCMC nrog kev hloov pauv ntawm tus kab mob. Qhov txiaj ntsig tau tshwm sim yog qhov sib txawv ntawm feem pua ​​​​ntawm cov meters taug kev sib raug zoo nrog creatinine. Ib yam li ntawd, Robertson et al. tsis ntev los no tau piav txog qee qhov kev hloov pauv hauv cov molecular muaj pes tsawg leeg ntawm COVID-19 cov zis ntev ntawm tus neeg mob, kuaj pom siv Raman spectroscopic / xam ntsuas [44].

Tsis zoo li qee tus kws sau ntawv uas tau pom tias cov kab mob inflammatory thiab autoimmune tsis tuaj yeem koom nrog hauv pathogenesis ntawm LC, peb tsis tuaj yeem pom muaj kev sib raug zoo ntawm cov lus teb rau kev kho mob nrog cov kab mob tsis zoo, tsuas yog qhov tsis zoo ntawm qhov sib txawv ntawm FIS rau qaug zog nrog cov titers. ntawm ANA [45–49]. Ntawm qhov tod tes, Kruger et al. Tsis ntev los no tau piav qhia, hauv ib pawg LC, qhov txo qis ntawm cov ntshav plasma kallikrein piv rau kev tswj hwm, nce qib ntawm platelet factor 4 (PF4) von Willebrand factor (VWF), thiab qib marginally nce ntawm -2 antiplasmin ( {{ 5}}AP). Lawv tau tawm tswv yim tias qhov muaj cov kab mob proinflammatory no tuaj yeem piav qhia tias yog vim li cas cov tib neeg uas muaj COVID ntev dhau los ua rau mob nkees nkees, ua tsis taus pa, lossis kev paub tsis meej [50]. Hauv qhov kev nkag siab no, peb pom tias platelets thiab fibrinogen tau nce ntxiv hauv cov neeg mob uas tsis teb.

Ntau qhov kev txwv yuav tsum tau txiav txim siab thaum txhais cov kev tshawb pom ntawm qhov kev tshawb fawb no. Ua ntej, raws li nws yog ib qho kev tshawb nrhiav, qhov txo qis ntawm cov qauv tuaj yeem txo qhov kev txheeb xyuas lub zog thiab muaj feem cuam tshuam rau qee qhov txiaj ntsig. Nrog tsuas yog cuaj tus neeg mob uas tau ua tiav cov kev kho mob, nws yog ib qho tseem ceeb kom paub txog cov kev txwv ntawm generalizability rau cov pej xeem loj. Yog li ntawd, cov kev tshawb pom los ntawm qhov kev sim ntsuas no yog kev tshawb nrhiav thiab yuav tsum tau txhais li ntawd. Qhov thib ob, lub sijhawm kawm tau txwv vim tias txoj haujlwm tshawb fawb tau siv ntau yam kev kho mob thiab kev saib xyuas txhua hnub tsis tuaj yeem cuam tshuam nrog. Thib peb, cov txiaj ntsig tsis tuaj yeem ua rau tag nrho cov pej xeem vim tsis muaj tus sawv cev ntawm cov txiv neej lossis cov neeg laus. Plaub, qhov xwm txheej ntawm kev kho mob tiv thaiv kev cuam tshuam los ntawm qhov muag tsis pom rau ob tus neeg koom thiab cov kws tshawb fawb, thiab tsis muaj pawg tswj hwm los tsim cov kev xav ntawm causality. Thib tsib, txawm hais tias DePaul Cov Lus Nug Txog Cov Mob Ntiag Tug yog daim ntawv nug tus kheej tau lees paub ntawm 54 cov tsos mob uas muaj kev ntxub ntxaug zoo heev los soj ntsuam thiab saib xyuas kev mob myalgic encephalomyelitis / chronic fatigue syndrome [51], peb txiav txim siab siv FIS thiab Borg nplai los ntsuas kev qaug zog. thiab dyspnea, feem. Thib rau, txawm hais tias txoj kev taug kev ntev tau nce ntxiv tom qab qhov kev kho mob, qhov no yuav yog ib feem ntawm cov txheej txheem ntawm tus kab mob. Txawm li cas los xij, lub ntsiab lus tseem ceeb ntawm txoj kev tshawb no yog tus naj npawb ntawm cov khoom sib txawv uas tau sau tseg thiab tsis muaj kev pheej hmoo cuam tshuam nrog kev cuam tshuam. Txawm li cas los xij, kev tshawb fawb ntxiv yog xav tau los ua pov thawj peb qhov kev tshawb pom.

5. Cov lus xaus

Hauv kev xaus, cov neeg mob uas muaj LC thiab qaug zog tau pom ib feem ntawm cov lus teb tab sis tau txais txiaj ntsig zoo rau kev cuam tshuam kev kho mob. Txawm hais tias tus qauv loj me me, feem ntau ntawm cov neeg mob tau teb rau kev kho mob. Lub xeev zoo ntawm cov khoom noj muaj protein muaj feem xyuam rau cov lus teb zoo dua rau kev saib xyuas kev tawm dag zog. Tsis tas li ntawd, cov txiaj ntsig tau cog lus hais txog kev tsim cov creatinine raws li qhov ua tau zoo ntawm biomarker ntawm cov lus teb rau kev kho mob rov qab los ua qhov tseem ceeb thiab txhim kho kev saib xyuas neeg mob.

Tus sau kev koom tes:Conceptualization, JB, MR (Marcela Renzulli), MO thiab TA; methodology, JB, MR (Monica Real), LB, MR (Marcela Renzulli), DR, MO, JAP, CP, and AM; software, JB, MR (Monica Real), MR (Marcela Renzulli), MO thiab TA; validation, RSS, thiab TA; kev soj ntsuam, JB, MR (Monica Real) thiab LB; kev tshawb nrhiav, JB, MR (Monica Real), MR (Marcela Renzulli), MO, CP, AM, thiab TA; Resources, JB, MR (Monica Real), MR (Marcela Renzulli), DR, JAP, MO, CP, RSS, DRP, thiab TA; cov ntaub ntawv curation, LB, thiab TA sau ntawv—kev npaj ua ntej, JB, MR (Monica Real) thiab TA; sau ntawv- tshuaj xyuas thiab kho, LB, MR (Marcela Renzulli), MO thiab RSS; visualization, JB, MR (Monica Real), MR (Marcela Renzulli), MO, RSS, thiab TA; kev saib xyuas, RSS, thiab TA; project tswj, TA; Kev nrhiav nyiaj txiag, TA Txhua tus kws sau ntawv tau nyeem thiab pom zoo rau cov ntawv luam tawm ntawm cov ntawv sau.

Nyiaj txiag:Txoj haujlwm no tau txais nyiaj los ntawm kev pub dawb los ntawm Lub Nroog Council of Perafort (rau Teresa Lub Yim Hli).

Institutional Review Board Statement:Txoj kev tshawb no tau ua raws li cov lus qhia ntawm Kev Tshaj Tawm ntawm Helsinki thiab tau pom zoo los ntawm Pawg Neeg Saib Xyuas Kev Ruaj Ntseg (lossis Pawg Neeg Saib Xyuas Kev Ncaj Ncees) ntawm Institut Investigació Sanitària Pere Virgili (IISPV) CEIm ( raws tu qauv code 156/2021).

Cov Lus Qhia Txog Kev Pom Zoo:Cov ntaub ntawv pom zoo tau txais los ntawm txhua yam kev koom tes hauv txoj kev tshawb fawb.

Cov ntaub ntawv muaj nyob:Tsis siv tau.

Kev lees paub:Peb ua tsaug rau qhov pub dawb los ntawm Lub Nroog Council ntawm Perafort uas ua rau txoj kev loj hlob ntawm qhov kev tshawb fawb no ua tau.

Kev tsis sib haum xeeb ntawm kev txaus siab:Cov kws sau ntawv tshaj tawm tsis muaj kev sib cav txog kev txaus siab.

Cov ntaub ntawv

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