CKM Kev Kho Mob Kev Pom Zoo: Kev txo qis ntshav qab zib thiab txo qhov hnyav yog qhov muaj txiaj ntsig zoo dua

Qhov teeb meem yog grim - rog dhau los yog rog yog sib cais los ntawm "cardio-renal-metabolic syndrome"

Cov ntaub ntawv kis mob tam sim no qhia tau tias yuav luag ib nrab ntawm cov neeg mob ntshav qab zib hom 2 (T2DM) thoob ntiaj teb tsis ua tiav cov hom phiaj tswj ntshav qab zib, ntawm cov rog rog lossis rog ntau dua 50%. Cov ntaub ntawv tshawb fawb qhia tau tias feem ntau ntawm cov neeg mob T2DM uas tsis ua tiav cov hom phiaj tswj ntshav qab zib (HbA1c<7%) and are overweight or obese is 49.5% and 89.7% in the United States, 46.4% and 85.3% in Europe, 51.5% and 52.7% in Japan, and 50.6% and 65.3% in my country. At the same time, the proportion of overweight or obese patients in T2DM has been increasing year by year.

Nyem rau Cistanche rau mob raum

Kev rog dhau los yog rog yog ib feem tseem ceeb ntawm pathophysiology ntawm T2DM. Kev rog dhau ntawm insulin tsis kam tuaj yeem ua rau mob hnyav ntawm cov ntaub so ntswg adipose thiab kev ua haujlwm tsis zoo ntawm cov piam thaj hauv lub cev, thaum kawg ua rau decompensation ntawm pancreatic cell function, thiab nce qhov hnyav lossis lub duav ncig yuav ua rau cov qib ntawm insulin tsis kam, uas tsis tuaj yeem ua rau muaj kev pheej hmoo. ntawm T2DM tab sis kuj nce qhov nyuaj ntawm kev tswj ntshav qab zib. Tsis tas li ntawd, kev rog rog kuj yog ib qho kev pheej hmoo rau lub plawv tsis ua haujlwm nrog kev khaws cia ejection feem (HFpEF). Qhov feem pua ​​​​ntawm HFpEF cov neeg mob uas rog dhau lossis rog yog siab li 85%. Kev ntsuas kev poob phaus tuaj yeem txhim kho HFpEF cov ntsuas ntsuas kev kho mob zoo.

Kev sib txuas ntau yam - ntshav qab zib, kab mob plawv, thiab kab mob raum mob sib cuam tshuam

Ib qho kev soj ntsuam zoo ntawm 2017 Kev Tshawb Fawb Ntiaj Teb Cov Kab Mob tau pom tias T2DM tau dhau los ua qhov ua rau muaj kab mob raum ntev (CKD). Piv nrog rau cov neeg mob uas tsis muaj CKD, cov neeg mob T2DM thiab CKD muaj kev pheej hmoo ntau ntxiv ntawm cov kab mob plawv thiab mob stroke. Qhov kev pheej hmoo ntawm cov hlab plawv tuag hauv cov neeg mob T2DM thiab CKD yog 2 zaug thiab 1 zaug siab dua li cov neeg mob uas yooj yim T2DM thiab CKD yooj yim, feem. Tsis tas li ntawd, ntshav qab zib ua ke nrog cov kab mob plawv (CVD) lossis CKD yuav ua rau lub neej poob ob. Piv nrog cov ntshav qab zib yooj yim lossis CKD, ntshav qab zib ua ke nrog CKD yuav ua rau muaj kev tuag ntau ntxiv.

Vim tias cov hlab plawv, lub raum, thiab cov kab mob metabolic sib cuam tshuam, lub tswv yim ntawm cardiovascular-renal-metabolic syndrome (CKM) tau los ua. Hauv xyoo 2023, American Heart Association (AHA) tau tshaj tawm cov lus pom zoo thawj coj ntawm CKM, uas tau piav qhia txog lub tswvyim ntawm CKM. CKM txhais tau tias yog kab mob uas tshwm sim los ntawm kev sib cuam tshuam ntawm pathophysiological ntawm kev rog thiab ntshav qab zib, CKD, thiab CVD. Cov ntaub ntawv tshawb fawb tiag tiag hauv ntiaj teb qhia tau hais tias feem ntau ntawm cov neeg mob T2DM ua ke nrog CKM syndrome yog siab li 93.7%.

Cov pov thawj tshiab-raws li kev kho mob pov thawj qhia tau hais tias tej zaum yuav muaj cov txheej txheem pathophysiological tshiab ntawm kev rog thiab T2DM thiab cov teeb meem cardiorenal.

Txoj kev daws teeb meem - "txo cov ntshav qab zib thiab poob phaus" ua rau lub plawv, lub raum thiab cov txiaj ntsig metabolic

Sodium-glucose co-transporter 2 inhibitors (SGLT2i) thiab glucagon-zoo li peptide-1 receptor agonists (GLP-1RA) muaj cov ntshav qab zib qis, poob phaus, thiab cov txiaj ntsig tseem ceeb hauv plawv thiab raum. Tus tshiab version ntawm ADA / EASD kev pom zoo pom zoo hais tias cov ntshav qab zib txo qis, poob phaus, kev tiv thaiv cardiorenal, thiab kev tswj hwm kev pheej hmoo ntawm cov hlab plawv yuav tsum tau siv los ua kev tswj hwm zoo rau T2DM.

Cov ntaub ntawv tshawb fawb hauv xyoo tas los no qhia tias cov tshuaj txo cov piam thaj tshiab xws li GLP-1RA, glucose-dependent insulinotropic polypeptide (GIP)/glucagon-zoo li peptide-1 (GLP-1) dual receptor agonists (xws li semaglutide thiab telportide) muaj kev cuam tshuam zoo rau kev tswj qhov hnyav hauv cov neeg mob T2DM, thiab cov nyhuv poob tuaj yeem txhim kho kev tswj ntshav qab zib hauv cov neeg mob T2DM. Yog li ntawd, ADA cov lus qhia pom zoo tias rau cov neeg mob hnyav lossis rog rog nrog T2DM, cov tshuaj txo cov piam thaj nrog qhov hnyav poob yuav tsum nyiam, suav nrog GLP-1RA thiab GIP/GLP-1 dual receptor agonists.

Cov ntsiab lus

Kev rog rog, T2DM, thiab cov kab mob cardiorenal muaj kev sib raug zoo thiab sib cuam tshuam thiab yuav tsum raug suav hais tias yog ib pab pawg neeg mob ntawm tag nrho cov theem. Kev tswj hwm ntawm T2DM yuav tsum muab qhov tseem ceeb sib npaug rau kev txo cov ntshav qab zib, poob phaus, tiv thaiv kab mob plawv, thiab kev tswj hwm kev pheej hmoo ntawm cov hlab plawv. Yog li ntawd, hauv kev kho mob, rau cov neeg mob hnyav lossis rog T2DM, cov tshuaj uas muaj ob qho tib si cov ntshav qab zib txo qis thiab txo qhov hnyav yuav tsum tau nyiam, thiab tus kheej, tus qauv, thiab kev kho mob ntau yam yuav tsum tau ua kom ua tiav cov hlab plawv, lub raum, thiab kev tswj cov metabolism.

Cistanche kho mob raum li cas?

Cistancheyog ib hom tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho ntau yam mob, suav nrograumkab mob. Nws yog muab los ntawm cov stems qhuav ntawm Cistanche deserticola, ib tsob nroj nyob rau hauv cov suab puam ntawm Tuam Tshoj thiab Mongolia. Lub ntsiab active Cheebtsam ntawm cistanche yogphenylethanoidglycosides, echinacoside cov tshuaj, thiabacteoside, uas tau pom tias muaj txiaj ntsig zoo rauraumnoj qab haus huv.

Kab mob raum, tseem hu ua kab mob raum, hais txog ib yam mob uas lub raum ua haujlwm tsis zoo. Qhov no tuaj yeem ua rau muaj cov khoom pov tseg thiab cov co toxins hauv lub cev, ua rau muaj ntau yam tsos mob thiab teeb meem. Cistanche tuaj yeem pab kho mob raum ase los ntawm ntau lub tswv yim.

Ua ntej, cistanche tau pom tias muaj cov nyhuv diuretic, txhais tau tias nws tuaj yeem ua rau cov zis ntau ntxiv thiab pab tshem tawm cov khoom pov tseg ntawm lub cev. Qhov no tuaj yeem pab txo lub nra ntawm lub raum thiab tiv thaiv kev tsim cov co toxins. Los ntawm kev txhawb nqa diuresis, cistanche kuj tseem tuaj yeem pab txo qis ntshav siab, ib qho teeb meem ntawm cov kab mob raum.

Ntxiv mus, cistanche tau pom tias muaj cov teebmeem antioxidant. Kev ntxhov siab oxidative, tshwm sim los ntawm qhov tsis sib xws ntawm kev tsim cov dawb radicals thiab lub cev tiv thaiv antioxidant, ua lub luag haujlwm tseem ceeb hauv kev mob raum. ies pab neutralize dawb radicals thiab txo Oxidative kev nyuaj siab, yog li tiv thaiv lub raum los ntawm kev puas tsuaj. Cov phenylethanoid glycosides pom hauv cistanche tau tshwj xeeb hauv kev tshem tawm cov dawb radicals thiab inhibiting lipid peroxidation.

Tsis tas li ntawd, cistanche tau pom tias muaj cov tshuaj tiv thaiv kab mob. Kev mob yog lwm yam tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov kab mob raum. Cistanche's anti-inflammatory zog pab txo cov zus tau tej cov pro-inflammatory cytokines thiab inhibit qhov ua kom o yuav tsum tau txoj kev, yog li alleviating o nyob rau hauv lub raum.

Tsis tas li ntawd, cistanche tau pom tias muaj cov teebmeem immunomodulatory. Hauv kab mob raum, lub cev tiv thaiv kab mob tuaj yeem ua rau tsis zoo, ua rau muaj kev mob ntau dhau thiab cov ntaub so ntswg puas. Cistanche pab tswj lub cev tiv thaiv kab mob los ntawm kev hloov kho kev tsim khoom thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li T hlwb thiab macrophages. Txoj cai tiv thaiv kab mob no pab txo qhov mob thiab tiv thaiv kev puas tsuaj ntxiv rau lub raum.

Ntxiv mus, cistanche tau pom los txhim kho lub raum kev ua haujlwm los ntawm kev txhawb nqa kev tsim kho ntawm lub raum hlab nrog cov hlwb. Lub raum tubular epithelial hlwb ua lub luag haujlwm tseem ceeb hauv kev pom thiab rov nqus cov khoom pov tseg thiab electrolytes. Hauv kab mob raum, cov hlwb no tuaj yeem raug puas tsuaj, ua rau lub raum ua haujlwm puas. Cistanche lub peev xwm los txhawb kev tsim kho ntawm cov hlwb no pab kho lub raum kom zoo thiab txhim kho lub raum tag nrho.

Ntxiv nrog rau cov kev cuam tshuam ncaj qha rau lub raum, cistanche tau pom tias muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev hauv lub cev. Txoj hauv kev zoo rau kev noj qab haus huv no tseem ceeb tshwj xeeb hauv cov kab mob raum, vim tias tus mob feem ntau cuam tshuam rau ntau lub cev thiab lub cev. che tau pom tias muaj kev tiv thaiv rau lub siab, lub plawv, thiab cov hlab ntsha, uas feem ntau cuam tshuam los ntawm kab mob raum. Los ntawm kev txhawb nqa kev noj qab haus huv ntawm cov kabmob no, cistanche pab txhim kho lub raum tag nrho thiab tiv thaiv kev mob ntxiv.

Hauv kev xaus, cistanche yog cov tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho mob raum. Nws cov active Cheebtsam muaj diuretic, antioxidant, anti-inflammatory, immunomodulatory, thiab regenerative teebmeem, uas pab txhim kho lub raum ua haujlwm thiab tiv thaiv ob lub raum los ntawm kev puas tsuaj ntxiv. , cistanche muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev, ua rau nws txoj hauv kev zoo rau kev kho mob raum.