Cistanche Deserticola Daim Ntawv Thov Txog Kev Kho Mob Parkinson

Yog xav paub ntxiv. thov hu rautina.xiang@wecistanche.com

Tus kab mob Parkinson(Parkinson's disease, PD), tseem hu ua tremor palsy, yog thawj zaug los ntawm British kws kho mob James Parkinson nyob rau hauv 1817. Cov yam ntxwv pathological hloov yog degeneration thiab poob ntawm dopaminergic neurons nyob rau hauv lub substantia nigra compacta nyob rau hauv lub midbrain, thiab tsim ntawm Lewy. lub cev nyob rau hauv lub cytoplasm ntawm cov seem neurons. Lewy lub cev yog cov fiber ntau zoo li eosinophilic suav nrog ntau cov proteins ua cov khoom tseem ceeb, xws li a-synuclein (Wang. synuclein), neurofilament protein, thiab ubiquitin.

Raws li cov tsos mob ntawm tus kab mob Parkinson, cov tshuaj suav tshuaj suav nrog qeb ntawm "fibrillation syndrome". Cov kab mob pathological yeej ib txwm ua raws li qhov tsis txaus thiab ntau dhau, nrog rau lub siab thiab lub raum tsis txaus yin thiab tsis muaj yin thiab yang ntawm qi thiab ntshav yog thawj qhov tsis txaus. Txij li thaum tus kab mob no muaj ntau dua nyob rau hauv cov neeg laus thiab cov neeg laus, kev kho mob yuav tsum tau them nyiaj ntau rau kev txhawb nqa lub siab thiab lub raum, txhawm rau kho cov hauv paus hniav. Kev tshawb fawb thiab kev nkag siab ntawm Parkinson tus kab mob hauv cov tshuaj suav tshuaj feem ntau yog tsom rau kev txav mus los tab sis tsis ua tib zoo mloog, thiab kev tshawb fawb txog cov tsos mob uas tsis yog lub cev muaj zog xws li cem quav.

Nyem qhov no kom paub ntau yam khoom

Kev tshawb fawb txog kab mob Parkinson's disease

Parkinson tus kab mob (PD)yog thib ob xwbAlzheimer's Disease (AD)thiab yog ib yam kab mob uas muaj cov kab mob neurodegenerative degeneration raws li nws lub ntsiab kev kho mob tshwm sim, thiab nws kuj yog ib tug kab mob nyob rau hauv nruab nrab-hnub nyoog thiab cov neeg laus. PD muaj cov yam ntxwv ntawm qhov pib qeeb, maj mam nce zuj zus, thiab muaj qhov tsis taus siab. Nws muaj ntau dua tom qab hnub nyoog 50, thiab cov txiv neej cov neeg mob me ntsis ntau dua li cov poj niam cov neeg mob. Clinically, tus kab mob feem ntau pib los ntawm ib sab sab sauv, thiab maj mam loj hlob mus rau sab qis ntawm tib sab, thiab tom qab ntawd mus rau sab qaum thiab sab qis ntawm sab nraud, qhia txog "N" zoo li kev loj hlob.

An epidemiological collaborative project involving 7 study populations in Europe, which investigated 22,158 PD patients, reported that 18,506 patients were >65 years old, and the overall prevalence of PD was in the >65-cov neeg muaj hnub nyoog ib xyoos. Qhov tshwm sim yog 1.8 feem pua ​​​​hauv 65- rau 69- pab pawg hnub nyoog, thiab 4.4 feem pua ​​​​hauv 85- rau 89- pawg hnub nyoog.

Nrog rau kev siv zog ntawm kev laus ntawm cov pej xeem hauv zej zog thiab kev cuam tshuam ntawm ib puag ncig, qhov kev nthuav dav thiab kev tsis taus ntawm PD yog nce xyoo los ntawm lub xyoo thoob plaws ntiaj teb, thiab kuv lub teb chaws tsis muaj kev zam. Yog li ntawd, nws yog ib qho tseem ceeb ntawm cov tswv yim tseem ceeb los ntxiv dag zog rau cov qauv kev kho mob ntawm cov neeg mob Parkinson's disease thiab txhim kho lub neej zoo ntawm cov neeg mob, uas yog lub luag haujlwm tsis muaj kev zam ntawm peb cov neeg ua haujlwm kho mob.

Cov teebmeem ntawm Cistanche los tiv thaiv Parkinson's Disease

Cistanche yog cov qia nqaij nrog scaly nplooj ntawm Cistanche, tseem hu ua "Desert Ginseng".Nws feem ntau yog muab faib rau hauv cov suab puam sov nyob rau sab qaum teb hemisphere, xws li Inner Mongolia, Qinghai, thiab lwm qhov chaw hauv kuv lub tebchaws.Cistanche deserticolatau pom thawj zaug hauv "Shen Nong's Materia Medica", ntxiv rau "Ben Cao Hui Yan", "Ben Cao Jing Shu", "Rihuazi Materia Medica", "Cov kws kho mob nto moo" thiab lwm phau ntawv tseem raug kaw. Cov kws tshawb fawb niaj hnub no tau them nyiaj ntau dua rau Cistanche deserticola thiab ua ntau yam kev tshawb fawb thiab kev tshuaj xyuas ntawm nws. Tam sim no, ze li ntawm 70 chemical Cheebtsam ntawm Cistanche deserticola tau raug cais thiab txheeb xyuas, feem ntau suav nrog phenethyl glycosides, lignans, thiab lawv cov glycosides, Iridoids thiab lawv cov kev phais, suab thaj, thiab lwm yam.

Cov kev tshawb fawb tshuaj niaj hnub no kuj tau ua pov thawj tias cistanche muaj lub luag haujlwm ntawm kev tiv thaiv lub paj hlwb, tiv thaiv qaug zog, tiv thaiv kev laus, txhim kho kev tiv thaiv kab mob, thiab txhim kho kev nco, ntxiv rau kev ua haujlwm ntawm invigorating lub raum thiab ntxiv dag zog rau yang, moistening cov hnyuv, thiab tshuaj laxative. Cov khoom xyaw tseem ceeb ntawm Cistanche deserticola yog phenyletory thiab tiv thaiv qhov tsis zoo stimuli.

Kev ua tau zoo thiab kev ua tshuaj pharmacological ntawm Cistanche

Cistanche yog siv ntau yam hauv cov tshuaj suav tshuaj tonic, qab zib, qab ntsev, sov hauv qhov xwm txheej, thiab belongs rau cov hnyuv loj thiab raum meridians. Nws muaj cov nyhuv ua kom sov lub raum yang thiab moistening lub plab. Nws tuaj yeem kho uterine txias infertility, impotence, thiab ejaculation ntxov ntxov, impotence thiab tsis muaj zog, lub duav thiab lub hauv caug mob, plab hnyuv dryness thiab cem quav, thiab lwm yam qab zib muaj peev xwm nourish, qab zib thiab sov tuaj yeem ntxiv yang, ntsev tuaj yeem nkag mus rau hauv lub raum, moisturizing thiab nourishing, cov khoom no yog cov tshuaj zoo rau tonifying raum yang, nourishing essence, thiab ntshav. Cov khoom no belongs rau cov plab hnyuv loj meridian thiab tuaj yeem ua rau cov hnyuv moisten thiab defecate, xws li Runchang Pills (siv ua ke nrog Agarwood thiab Ma Siren) los kho cem quav los ntawm lub cev raug mob; Ji Chuan Jian (sib npaug rau Alisma, Angelica, thiab Achyranthes) los kho lub raum tsis txaus Ua los ntawm cem quav.

Cov kev tshawb fawb tau pom tias Cistanche deserticola tuaj yeem ua rau lub cev hnyav ntawm "mob raum-yang deficiency" nas, ua kom lub sijhawm txias txias ntawm cov nas, thiab muaj cov nyhuv ua kom sov thiab ua kom lub raum-yang. Cov kev tshawb fawb tau pom tias Cistanche muaj kev tiv thaiv kab mob Parkinson, cerebral ischemia, Alzheimer's disease, thiab lwm yam kab mob neurological. Cov kws tshawb fawb tau kawm txog kev tiv thaiv kev qaug zog ntawm Cistanche deserticola los ntawm kev sim tsiaj. Cov txiaj ntsig tau pom tias Cistanche deserticola tuaj yeem ua kom ntev lub sij hawm qaug zog ntawm nas thiab txhim kho kev tawm dag zog ntawm nas, yog li ncua sijhawm tiam neeg ntawm kev qaug zog thiab muaj kev tiv thaiv kev qaug zog. Cov kws tshawb fawb sawv cev los ntawm Xuan Guodong tau kawm txog kev tiv thaiv kev laus ntawm phenylethanoid, qhov tseem ceeb ntawm Cistanche deserticola. Lawv siv D-galactose los tsim cov qauv kev laus hauv cov nas. Cov txiaj ntsig tau pom tias phenylethanoid muaj kev tiv thaiv kev laus. Kev ua haujlwm ntawm SOD (superoxide dismutase) hauv nas hlwb cov ntaub so ntswg thiab ntshav ntshav muaj feem xyuam. Cistanche deserticola muaj cov nyhuv ntawm stimulating lub qog pituitary thiab adrenal cortex, yog li tswj lub cev tiv thaiv kab mob.

Tsis tas li ntawd, Cistanche deserticola muaj lub luag haujlwm ntawm kev tiv thaiv myocardial ischemia, txhim khokev ua haujlwm ntawm kev sib deev, tiv thaiv qog, thiab tiv thaiv daim siab puas.

Kawm txog kev kho tus kab mob Parkinson nrog Cistanche

Cistanche deserticolamuaj lub zog ua kom sov thiab txhawb nqa lub raum yang, nourishing essence thiab ntshav, thiab tuaj yeem siv rau hauv kev kho mob Parkinson tus kab mob nrog rau daim siab thiab lub raum tsis txaus ua lub ntsiab pathogenesis. Nrog rau kev nce qib ntawm kev tshawb fawb thiab thev naus laus zis, cov neeg ua haujlwm kho mob niaj hnub kuj tau tshawb fawb txog kev kho mob ntawm Cistanche deserticola ntawm Parkinson tus kab mob los ntawm kev tshawb fawb.

Txoj kev tshawb fawb tau lees paub tias lub ntsiab lus tseem ceeb ntawm Cistanche deserticola tuaj yeem ua rau kom muaj kev qhia ntawm tyrosine hydroxylase hauv substantia nigra thiab cov ntsiab lus ntawm dopamine hauv striatum, thiab los ntawm cov txheej txheem no, nws tuaj yeem txhim kho tus cwj pwm ntawm PD qauv nas. nyhuv. Wang Hu et al. tshawb xyuas cov txiaj ntsig ntawm Cistanche deserticola extract ntawm cov ciaj sia taus, GADD153 (DNA puas-inducible gene 153), thiab cov protein qhia ntawm Parkinson tus kab mob cell qauv los tshawb txog cov txheej txheem ntawm kev ua ntawm Cistanche deserticola. Cell proliferation thiab txo cov kev qhia ntawm GADD153 protein, uas ua rau nws tiv thaiv kev puas tsuaj ntawm cell mediated los ntawm 1-methyl-4-phenyl-pyridine ion (MPP ntxiv). Hauv kev soj ntsuam kev soj ntsuam, nws tau pom tias cov tshuaj raws li Cistanche deserticola tuaj yeem tswj hwm cov tshuaj levodopa thiab ncua sij hawm ntau npaum li cas. Thiab los ntawm kev sim kev tshawb fawb, nws tau pom tias tag nrho cov glucosides ntawm Cistanche tuaj yeem ua tiav kev txhim kho zoo los ntawm cov txheej txheem ntawm inhibiting kev qhia ntawm IX-synuclein ntawm mitochondria. Txhim kho cov neurobehavior ntawm PD qauv nas thiab inhibit lawv txoj kev tuag. Pu Xiaoping tau tsim ib qho qauv ntawm apoptosis-hais txog tus kab mob Parkinson, txhawm rau kawm txog cov txiaj ntsig ntawm cov tshuaj suav tshuaj Cistanche deserticola rau hauv campneoside II, thiab pom tias campneoside II tuaj yeem cuam tshuam MPTP-induced apoptosis, uas yuav cuam tshuam rau nws qhov txo qis. nyob rau hauv tus nqi xau ntawm cellular lactate dehydrogenase.

Nws tau pom tias echinacea, cov khoom xyaw nquag ntawm Cistanche deserticola, tuaj yeem txo qis apoptosis ntawm paj hlwb. Txhawm rau kawm txog cov txiaj ntsig ntawm Cistanche deserticola extract ntawm lub paj hlwb, nws tau pom tias ductal sab B muaj qhov cuam tshuam rau MPP ntxiv rau -induced neuronal apoptosis thiab oxidative kev nyuaj siab hauv PCI2 hlwb (ib feem siv neuronal cell kab). Lwm txoj kev tshawb fawb tau pom tias echinacoside tuaj yeem cuam tshuam qhov nce ntawm biliverdin reductase B thiab txo cov oxidative kev nyuaj siab puas tsuaj ntawm dopaminergic neurons.