Kev tshawb fawb kuaj mob ntawm cov tshuaj tsoos tshuaj hauv kev kho cov menyuam pw tsis tsaug zog hauv cov poj niam menopaial

Lawm,Kuj hu uaib perimenopause, yog hais txog lub sijhawm ua ntej thiab tom qab lawm. Nyob rau lub sijhawm no, poj niam lub qe qe qe menyuam maj mam txo qis, uas ua rau muaj kev tawm hws kub, thiab ua tsis tau zoo hmo ntuj, thiab tsis muaj lub neej ntawm cov poj niam menopausal. Ntawm lawv, pw tsaug zog cuam tshuam yog ib qho tseem ceeb tshaj plaws ntawm cov poj niam menopausal, sawv ntxov thaum sawv ntxov, lossis muaj ntau tus npau suav thiab tau pib yooj yim [1].

Hu rau tam sim no

Zoo cistanche extract tshwj xeeb tshaj yog rauCov poj niam lawm

Tiv tauj peb kom tau txais cov ntsiab lus ntau ntxiv txog kev siv nws

Ntev mus pw tsaug zogtuaj yeem ua rau endocrine thiab cov hlwb lub hlwb ua ke nyob rau hauv lub cev, thiabNce kev pheej hmoo ntawm cov ntshav qab zib, kev ntshav siab,myocardial infarction, kev rogthiabLwm Yam Kab Mob [2].

Cov kev tshawb fawb tau pom tias qhov tshwm sim ntawm kev pw tsaug zog hauv cov poj niam menopausal tau nce xyoo los ntawm lub xyoo. Qhov tshwm sim hauv kuv lub teb chaws hnub nyoog 40 txog 65 xyoos yog kwv yees li 46.87%, uas yog qhov siab dua li ntawm Tebchaws Europe thiab 3]. Tam sim no, cov ntsiab lus tseem ceeb ntawm Western tshuaj rau kev kho cov menyuam pw tsis muaj kev cuam tshuam hauv Menopausal cov tshuaj kho thiab cov tshuaj sedative thiab cov tshuaj sedatotic. Txawm hais tias muaj qee qhov kev kuaj mob, cov tshuaj hormone hloov kho kev pheej hmoo ntawm cov qog nqaij hlav cancer hauv poj niam; Kev siv cov tshuaj sedatives thiab cov tshuaj hypnotic tau nquag siv tshuaj yeeb, thiab muaj ntau txoj kev tsis zoo, thiab kev ua tau zoo ntev [4].
Raws li cov lus qhia ntawm cov ntsiab lus thiab kev kho mob suav, kev txhaj tshuaj ntawm suav thiab lwm yam kev kho mob, uas muaj ntau yam kev tsis zoo, thiab muaj kev ua tau zoo. Lawv tuaj yeem koom tes nrog Western tshuaj kho mob thiab muaj cov txiaj ntsig ntawm kev ua kom muaj kev ua tau zoo thiab txo qis toxicity. Kab lus no luv luv xaus cov xwm txheej tam sim no, kev kho mob ntawm cov poj niam kho mob uas pw tsaug zog hauv cov poj niam muaj mob hauv nroog

1. ETiology thiab Pathogenesis

Tsoos suav tshuaj tsis muaj cov ntaub ntawv tshwj xeeb ntawm cov ntaub ntawv pw tsaug zog pw tsaug zog, thiab feem ntau ua rau lawv pw tsaug zog "," Tsis muaj peev xwm pw tsaug zog "," Lub cev tsis tuaj yeem pw tsaug zog "," Tsis muaj peev xwm pw tsaug zog "," Tsis muaj peev xwm pw tsaug zog "," Tsis muaj peev xwm pw tsaug zog "," Tsis muaj peev xwm pw tsaug zog "," Lub qhov muag tsis tuaj yeem ze ", thiab lwm yam hauv cov tshuaj suav. Cov tsos mob ntshav thiab pw tsaug zog "hais tias:" Rau cov neeg uas tsaug zog, tus neeg pw tsaug zog, tus neeg pw tsaug zog, tus plig rov qab mus rau lub siab. " [5] "Lei Zheng Zhi Cai" hais tias: "Yuav tsum mob rau cov ntshav, mob ntshav yog depleted, thiab insomnia rau xyoo." [6] "Shen phau ntawv ntawm kev hwm lub neej" hais tias: "Ob lub plawv thiab tus neeg tsis paub meej thiab tsis muaj zog vim tsis muaj zog thiab nyob tsis tswm." [7] "Golden Chamber cov khoom thiab lub plawv classic" hais tias: "Thaum tus ntsuj plig tsaug zog, tus ntsuj plig nyob hauv lub siab, yog li tus ntsuj plig tsis tau khaws cia, lawv tsis tuaj yeem pw." [8] Cov ntaub ntawv saum toj no qhia pom tias insomnia yog feem ntau yog cuam tshuam rau lub siab, mob siab, thiab tus po. Raws li lawv tus kheej kev xyaum kuaj mob thiab cov ntsiab lus ntawm cov kws ua haujlwm tau kawm ntxiv thiab kawm txog cov kws kho mob thiab pathogenesis ntawm menopaial pw tsis xwm yeem. Professess Wang Ping ntseeg tias cov kab mob ntawm tus kab mob no yog qhov tsis muaj zog, thiab lwm yam kev raug mob ntawm Qi thiab ntsuj plig, ua rau muaj Insomnia [9].

Professor song Jun tau npaj tseg los ntawm kev txeeb chaw ntawm cov lus phem, uas tau txuas rau ntawm cov lus phem, uas tau txuas rau ntawm Wei Qi los ntawm Yin [10].
Professor lu shaoguang pom nyob rau hauv chaw kuaj mob uas daim siab nyuaj siab yog lub pathogenesis ntawm kev ua phem rau cov neeg mob perimenopausal [11]. Professor Liu Zau Zessi ntseeg tias cov poj niam menopausal ntau dua los ntawm insomnia vim tsis txaus ntseeg, mob siab rau lub raum tsis txaus ntseeg, thiab mob plab thiab kev ntxhov siab thiab lub ntiaj teb kev ntxhov siab [12]. Xib fwb Zhang Zhiyuan ntseeg tias lub ntsiab ua rau ntawm menopailim lub insomnia yog qhov tsis muaj kev sib txuas lus ntawm lub plawv thiab raum. Cov dej thiab hluav taws ntawm lub plawv thiab raum tsis txuas nrog. Lub raum dej tsis txaus, lub plawv hluav taws yog nyob ib leeg, thiab yin thiab yang tsis muaj kev pab, uas cuam tshuam tus ntsuj plig thiab ua rau muaj mob. [13] Xib Fwb Zhang Boli ntseeg tias tus kab mob no tau tshwm sim los ntawm kev sib txuas lus hauv lub cev, thiab ya los ua tsis tau, uas ua rau lub neej sib txawv thiab ua rau lub voj voog ua phem. Yog li ntawd, cov khoom lag luam pathological yuav tsum tsis txhob ua yeeb yam. [14]

Hauv cov ntsiab lus, cov lus qhia thiab pathogenesis ntawm cov poj niam menopausality feem ntau yog vim tsis muaj plab hnyuv siab, thiab yin qhov tsis txaus, thiab yin tsis muaj kev sib cuam tshuam ntawm yin thiab yaj. Vim tias lub cev tshwj xeeb ntawm lub cev ntawm menopausal poj niam, Tiangui maj mam tsis lees paub, Yang-Fu Organs tsis sov thiab kev ua haujlwm tsis zoo. Yin yog tsis muaj ntshav thiab ntshav tsis txaus, tus ntsuj plig tsis siv, lossis kua ntshav thiab siv lub cev kom nquag los ua cov ntshav siab thiab ua rau muaj kab mob no.

2 tus mob sib txawv thiab kev kho mob

Hais txog syndrome sib txawv thiab kev faib tawm cov poj niam menopausal lub suab pw tsis tsaug zog, txhua tus kws kho mob muaj nws tus kheej. Tam sim no, muaj ntau hom kev sib txawv ntawm TCM thiab kev faib tawm ntawm tus kab mob no, thiab cov hau kev sib txawv. Feem ntau ntawm cov chaw kuaj mob siv tshuaj rau cov tshuaj thiab kev siv tshuaj rau tus kheej. Los ntawm kev tshuaj xyuas cov ntaub ntawv cov ntaub ntawv thiab cov lus qhia no faib cov poj niam pw tsis taus

2.1 Lub raum tsis muaj peev xwm thiab daim siab dag mob siab

JI Mingzhi li al. [16] Randomly muab faib ua ntej 72 tus neeg mob uas muaj lub raum tsis txaus thiab daim siab nyuaj rau pab pawg kho thiab pab pawg tswj hwm, 36 kis xwm txheej hauv txhua pab pawg. Cov pab pawg neeg kho mob tau muab cov tshuaj lom zem ntawm no thiab xiaoya hmoov nrog kev hloov kho, 1 koob tshuaj ib hnub, sov ua ntej yuav mus pw. Cov pab pawg tswj hwm tau muab cov ntsiav tshuaj diazepam 2. 5-5} mg txhua zaus, ib hnub; Oryzanol 10-30 mg txhua zaus, 3 zaug hauv ib hnub, hais lus. Ob pawg tau kho rau 14 hnub. Cov txiaj ntsig tau tag nrho cov pab pawg kho kom zoo (91.67%) tau nce siab dua li ntawm pawg tswj (69.44%) (p<0.05). Wang Feifeng et al. [17] randomly divided 52 patients with perimenopausal insomnia of kidney deficiency and liver depression into a treatment group and a control group, 26 cases in each group. The treatment group was treated with Ganmai Dazao Decoction, 1 dose per day, decocted in water and taken warm twice; the control group was given estazolam tablets (10 mg once a day) combined with oryzanol (20 mg 3 times a day) orally. After 3 months of treatment, the total effective rate of the treatment group (92.3%) was significantly higher than that of the control group (80.8%) (P<0.01).

Yao Zaoter li al. [18] Randomly muab faib 113 nrog cov neeg mob pw tsaug zog ntawm lub raum tsis muaj peev xwm thiab kev sim siab rau cov pab pawg kho thiab pawg tswj. Tus 60 tus neeg mob hauv pab pawg kho mob tau raug kho rau lub plawv thiab kev kub siab, tshem tawm cov ntshav siab Hauv paus, 15 g txhua tus ntawm lucidum, ziziphus jacktiorrhiza, 20 g ntawm Albizizia Julibrissin bark, 30 g ntawm polygonum multiflorum. Cov tshuaj yog ib koob tshuaj ib hnub, muab faib ua ob koob tom qab noj mov. Lub 53 cov neeg mob hauv pab pawg tswj hwm tau muab 2 mg ntawm Estazolam ntsiav tshuaj, noj los ntawm 30 feeb ua ntej yuav mus pw txhua hmo. Cov txiaj ntsig tom qab 8 lub lis piam ntawm kev kho, tag nrho cov txiaj ntsig tag nrho ntawm cov pab pawg kho (91.7%) tau nce siab dua li ntawm pawg tswj (73.5%) (p<0.05); the degree of improvement in hormone levels was significantly better than that of the control group (P<0.05); the TCM syndrome score, Pittsburgh Sleep Quality Index (PSQI) scale score, hot flashes, sweating, sexual pain, headache, palpitations and other symptom scores were significantly lower than those of the control group (P<0.05). The results showed that the Zishen Jieyu Ningxin prescription can effectively improve the various indicators of perimenopausal sleep disorders of kidney deficiency and liver depression type, and has a better efficacy than estazolam tablets. Zhang Ya et al. [19] divided 116 perimenopausal insomnia patients with kidney deficiency and liver depression into a control group and a treatment group using a random number table method, with 58 cases in each group.

Pawg tswj hwm tau muab cov ntsiav tshuaj Entazolam, 1 mg txhua zaus, ib hnub; Cov pab pawg neeg kho mob tau muab cov lus qhia yinxu yinxu (10 g txhua ntawm Adenophali, Citrus aurantium, Bencuma Aromatic Corniona, Cortek Albizziae, Rhizoma Alismatis, 6 g ntawm Licorice) ntawm lub hauv paus ntawm txoj kev kho mob ntawm pawg tswj hwm, 1 koob tshuaj ib hnub, ob npaug rau thaum sawv ntxov thiab yav tsaus ntuj. Tom qab 4 lub lim tiam ntawm kev kho, cov qhab nia ntawm psqi nplai kev nyuaj siab (SDS) thiab cov cim rau tus kheej yog qis dua cov uas nyob hauv pawg tswj (p<0.05), and the scores of 8 quality of life items and serum estradiol (E2) level were significantly higher than those in the control group (P<0.05). The results showed that Songyu Yinxu prescription combined with estazolam tablets was superior to estazolam tablets alone in improving sleep quality, alleviating depression and anxiety, and improving clinical symptoms in the treatment of perimenopausal insomnia with kidney deficiency and liver depression. Li Ying et al. [20] randomly divided 103 patients with perimenopausal insomnia of kidney deficiency and liver depression into a control group and a treatment group. The control group received estazolam tablets, and the treatment group received Chaihu Jia Longgu Muli Decoction combined with auricular acupoint pressing on the basis of the treatment method of the control group. Both groups took 7 days as one course of treatment, and a total of 3 courses of treatment were given. Results After treatment, the PSQI, SDS, SAS scores and TCM symptom scores of the treatment group were significantly lower than those of the control group (P < 0.05); the serum 5-hydroxytryptamine (5-HT) and dopamine (DA) levels were significantly higher than those of the control group (P < 0.05). This indicates that Chaihu Jia Longgu Muli Decoction, auricular acupoint pressing beans combined with estazolam tablets can improve the sleep quality of perimenopausal insomnia patients with kidney deficiency and liver depression, and the efficacy is better than that of simple estazolam tablets.

2.2 Lub plawv mob-raum ceev

Qiao Wei li al. [21] Random tau muab faib 60 tus neeg mob uas muaj perimenopausaly thiab insomnia rau hauv pab pawg tswj hwm thiab pab pawg kho, hauv txhua pab pawg. Pawg tswj hwm tau kho nrog Estazolam ntsiav tshuaj, 2 mg ib hnub, ua ntej yuav mus pw; Cov pab pawg kho mob tau kho nrog Tianwang Buxin Dan thiab Jiaotai Wan ntxiv lossis tshuaj noj tsawg, sov rau ib hnub thiab 2 h ua ntej yuav mus pw, 200 ml txhua lub sijhawm.
Tom qab 4 lub lim tiam ntawm kev kho, tag nrho cov txiaj ntsig tag nrho ntawm cov pab pawg kho ({}}}}}. {8}} 5); Tom qab kho, cov qhab nia psqi, Kupperman cov qhab nia thiab {} h dynamman cov qhab nia tau qis dua li cov ntawm pawg tswj hwm (p <}}}}}}}}}}}}}}}}}} Cov Ntshav Qab Zib E2 ntawm Pawg Kho Mob tau nce siab dua li ntawm pawg tswj hwm (LH) qis dua li cov pawg tswj (P <0.05); Qhov tshwm sim ntawm cov kev cuam tshuam tsis zoo hauv pab pawg kho (17.24%) tau qis dua li ntawm pawg tswj (44.82%); Tom qab 2 lub lis piam rov qab, qhov kev rov ua dua tshiab ntawm pawg kho mob (10.34%) tau qis dua li ntawm pawg tswj (31.03%) (P <0.05).

Cov txiaj ntsig tau pom tias Tianwang Buxin Dan ua ke nrog Jiaotai wan ntxiv lossis cov mob hauv cov neeg mob ua haujlwm tau zoo dua, nrog cov kev tsis sib haum xeeb. Li yang [22] Randomly Faib 98 tus neeg mob pw tsaug zog Tsis txaus ntseeg thiab lub plawv dhia ua ke rau hauv pawg Western Western tshuaj pab pawg tau kho nrog Estazolam ntsiav tshuaj, 1 mg Txhua zaus, 30 feeb ua ntej yuav mus pw txhua hmo; Cov pab pawg ua ke tau kho nrog Zixin Yanghen Decoction (10 g txhua tus neeg ua haujlwm, corniaoplrhinus, Kev tawm tsam, poria, salvia miltiorrhiza, thiab 6 g ntawm schisandra chinensis) raws li ib hnub, ib hnub ob zaug, sawv ntxov thiab yav tsaus ntuj. Tom qab 30 hnub ntawm kev kho mob, tag nrho cov pab pawg ua haujlwm tau zoo (91.84%) tau nce siab dua li cov pab pawg Western pab pawg (75.51%) (p<0.05), and the PSQI score, Spiege sleep score, Kupperman score and TCM syndrome score of the combined group were significantly lower than those of the western medicine group (P<0.05). The results showed that the effect of estazolam tablets combined with Zixin Yangshen Decoction in treating menopausal patients with sleep disorders and heart-kidney disharmony was better.
Hu ning [23] muab faib ua ke tau 72 menopausal cov poj niam nrog pw tsaug zog rau hauv pab pawg tswj thiab pab pawg kho, nyob rau hauv txhua pab pawg. Cov pab pawg tswj hwm tau muab 10 mg ntawm tartaric kua qaub ntsiav tshuaj, noj hais lus ua ntej mus pw txhua hmo; Cov pab pawg neeg kho mob tau muab tus kheej ua kom zoo nkauj, pliaycladus, sem angelycyc rehen, Acupoint (15 min txhua zaus, ib zaug ib hnub). Tom qab 4 lub lim tiam ntawm kev kho, tag nrho cov txiaj ntsig tag nrho ntawm cov pab pawg kho (83.3.3%) tau nce siab dua li ntawm pawg tswj (58.3%) (p<0.05). Professor Xiao Chengcong treated menopausal insomnia from the perspective of the heart, kidney and liver. He believed that the key to the pathogenesis of insomnia lies in the disharmony between the heart and kidney and the deficiency of liver and kidney yin. He created the Gengxin prescription (15 g each of Ligustrum lucidum, Ecliptae macrophylla, Radix Rehmanniae, Paeonia lactiflora, Fructus Lycii, Lilium, Salvia miltiorrhiza, Tribulus terrestris, Cortex Albizziae, Caulis Polygoni Multiflori, 10 g of Tribulus terrestris, 30 g each of Raw Dragon Bone and Raw Oyster, 3 g of Lotus Seed Heart, 12 g of Rhizoma Anemarrhenae) to connect the heart and kidney and nourish the kidney and liver. The prescription was adjusted according to the symptoms and the clinical efficacy was significant [24].