Cell Sub-journal: Kev Npaj Cov Tshuaj Tiv Thaiv Swallowable RNA, Capsule Delivery Of MRNA Vaccine Yuav Tau Txais
Mar 28, 2022
Hu rau: Audrey Hu Whatsapp / hp: 0086 13880143964 Email:audrey.hu@wecistanche.com
Cov tshuaj tiv thaiv mRNA tau dhau los ua nto moo hauv kev tawm tsam lub kaus mom tshiab, thiab cov zej zog kev tshawb fawb txog lawv tsis nres.
Thaum Lub Ib Hlis 31, Matter, cov ntawv xov xwm tseem ceeb ntawm Cell Xovxwm hauv thaj chaw ntawm cov ntaub ntawv, luam tawm kev kawm online los ntawm cov kws tshawb fawb los ntawm Massachusetts Institute of Technology (MIT), lub tuam txhab biopharmaceutical thoob ntiaj teb Novo Nordisk thiab lwm pab pawg. Lawv tau tsim ib txoj kev ntim RNA rau hauv ib lub tshuaj ntsiav tshwj xeeb uas tuaj yeem nqos tau. Ntxiv rau kev siv los ua kom cov pej xeem lees txais cov tshuaj tiv thaiv, pab pawg tshawb fawb cia siab tias txoj hauv kev no tuaj yeem siv los xa lwm cov tshuaj RNA lossis DNA ncaj qha mus rau hauv txoj hnyuv, ua kom yooj yim kho cov kab mob hauv plab xws li mob plab.
cistanche cov txiaj ntsig: Txhim kho kev tiv thaiv
"Nucleic acids, tshwj xeeb tshaj yog RNA, yog cov rhiab heev rau degradation, tshwj xeeb tshaj yog nyob rau hauv lub digestive ib ntsuj av. Kev kov yeej qhov kev sib tw no qhib rau ntau yam kev kho mob, nrog rau muaj peev xwm txhaj tshuaj tiv thaiv ntawm qhov ncauj txoj kev." Brigham, tus pab xibfwb qhia ntawv hauv MIT Lub Tsev Haujlwm Saib Xyuas Kev Siv Tshuab thiab Cov Poj Niam Tsev Kho Mob gastroenterologist Giovanni Traverso tau hais.
Traverso yog ib tus kws sau ntawv sib txuas ntawm txoj kev tshawb no, thiab lwm tus kws sau ntawv yog Robert Lange, thawj tus neeg hauv kev lag luam thoob ntiaj teb cov ntaub so ntswg engineering. Raws li lub vev xaib raug cai, Lange yog ib qho ntawm 12 tus kws tshaj lij hauv tsev kawm qib siab hauv MIT, thiab tus tswv cuab yau tshaj plaws ntawm American Academy of Sciences, Engineering, thiab Tshuaj.
Tau ntau xyoo, Langer thiab Traverso cov chaw sim tau tsim txoj hauv kev tshiab los xa cov tshuaj mus rau txoj hnyuv. Hauv xyoo 2019, cov kws tshawb fawb tau tsim cov tshuaj ntsiav uas, thaum nqos, tuaj yeem xa cov tshuaj zoo li insulin rau hauv ob sab phlu. Xyoo 2021, cov kws tshawb fawb tau mus ua qauv qhia tias lawv tuaj yeem siv cov tshuaj ntsiav kom xa cov macromolecules xws li monoclonal antibodies hauv cov kua. Tom qab ntawd, cov kws tshawb fawb tau txiav txim siab sim siv cov tshuaj ntsiav kom xa cov nucleic acids.
cistanche stems
Raws li tau hais los saum no, nucleic acids tau yooj yim degraded tom qab nkag mus rau tib neeg lub cev, yog li lawv yuav tsum tau nqa los ntawm cov khoom tiv thaiv. Rau txoj kev tshawb no, pab pawg MIT tau siv hom tshiab ntawm polymer nanoparticles nyuam qhuav tsim hauv Langer thiab Traverso labs. Cov khoom no, uas xa RNA ua tau zoo, yog tsim los ntawm cov polymer hu ua poly (beta-aminoester).
Txhawm rau kuaj cov kab mob, pab pawg tshawb fawb thawj zaug txhaj rau hauv lub plab ntawm cov nas yam tsis tas siv cov tshuaj xa tuaj. Yog tias cov hlwb ua tiav RNA, cov neeg sau xov xwm cov protein uas tau sau los ntawm RNA lawv tuaj yeem kuaj pom hauv cov ntaub so ntswg. Cov kws tshawb fawb pom cov neeg sau xov xwm cov proteins hauv cov nas lub plab thiab daim siab, qhia tias RNA tau coj los ntawm lwm yam kabmob hauv lub cev thiab coj mus rau daim siab, uas lim cov ntshav.
cistanche tawv
Tom ntej no, cov kws tshawb nrhiav lyophilized RNA-nanoparticle complexes thiab thauj lawv mus rau hauv cov tshuaj xa tshuaj capsules, kev tshawb fawb ntxiv kev koom tes nrog cov kws tshawb fawb los ntawm Novo Nordisk. Pab neeg tshawb fawb tau ntim txog 50 micrograms ntawm mRNA rau hauv txhua lub tshuaj ntsiav thiab muab peb lub capsules rau hauv tus npua lub plab rau tag nrho 150 micrograms ntawm mRNA. Qhov ntawd yog mRNA ntau dua li tam sim no siv Covid-19 cov tshuaj tiv thaiv, uas muaj 30 txog 100 micrograms ntawm mRNA.
cistanche tshuaj ntsuab
Hauv kev tshawb fawb nrog npua, cov kws tshawb fawb pom tau tias cov neeg sau xov xwm cov protein tau ua tiav los ntawm lub plab hlwb, tab sis tsis pom lwm qhov hauv lub cev. Lawv tau hais tias hauv kev ua haujlwm yav tom ntej, lawv cia siab tias yuav nce RNA nce los ntawm lwm lub cev los ntawm kev hloov cov nanoparticles los yog nce cov koob tshuaj.
Txawm li cas los xij, Abramson kuj tau hais tias nws tseem muaj peev xwm ua kom muaj zog tiv thaiv kab mob thaum muab rau lub plab ib leeg. "Muaj ntau lub cev tiv thaiv kab mob hauv lub plab zom mov, thiab txhawb kev tiv thaiv kab mob hauv plab hnyuv yog ib txoj hauv kev paub los tsim cov tshuaj tiv thaiv kab mob."
Pab neeg tshawb fawb npaj yuav tshawb xyuas ntxiv seb lawv puas tuaj yeem xa cov tshuaj tiv thaiv mRNA los ntawm cov tshuaj ntsiav los ua kom lub cev tiv thaiv kab mob, suav nrog kev ua kom B thiab T hlwb. Txoj hauv kev no kuj tseem siv tau los tsim cov kev kho mob rau cov kab mob hauv plab uas nyuaj rau kev kho nrog cov tshuaj subcutaneous. "Peb xav tias qhov no yog txoj hauv kev zoo los kho cov kab mob sib txawv uas muaj nyob hauv plab hnyuv," Abramson tau hais.
