CCL7 Raws li Tus Neeg Saib Xyuas Kev Ua Phem Txhaum Cai Tshiab hauv Kab Mob plawv, Ntshav Qab Zib Mellitus, Thiab Kab Mob Raum Ⅱ

Xaus

Kev qhia siab CCL7 tau pom nyob rau hauv kab mob plawv (Table 1), DM (Table 2), thiab kab mob raum (Table 3). Txawm li cas los xij, tam sim no CCL7- cov kev tshawb fawb ntsig txog tau ua los ntawm cov qauv sib txawv hauv ntau hom. Muab cov ntaub ntawv txwv tsis pub, nws yuav nyuaj rau kev txhais cov ntsiab lus ntawm mRNA thiab cov protein hauv cov kab mob no. Kev tshawb fawb yav tom ntej yuav tsum tau qhia meej txog cov teeb meem no. Thaum cov ncauj lus kom ntxaws txog lub luag haujlwm ntawm CCL7 thiab cov cim qhia txog txoj hauv kev hauv cov kab mob no xav tau kev pom zoo ntxiv, nws tau pom tias CCL7 tuaj yeem txhawb txoj kev loj hlob ntawm atherosclerosis thiab aortic aneurysm thiab ua lub luag haujlwm tseem ceeb hauv kev kho mob.inflammatory txheej xwmhauv qab feem ntaukab mob vascular, DM, thiabkab mob raumlos ntawm attracting

NYEEM NTXIV RAU HAUV NO KOM PAUB PAUB TIAS CISTANCHE FOR KIDNEY DISEASE

Table 1 Cov ntsiab lus ntawm CCL7 nyob rau hauv cov kab mob plawv hauv tsab xov xwm no

Table 2 Cov ntsiab lus ntawm CCL7 hauv ntshav qab zib mellitus hauv tsab xov xwm tshuaj xyuas no

Table 3 Summary ntawm CCL7 nyob rau hauv cov kab mob raum nyob rau hauv no tsab xov xwm tshuaj xyuas

macrophages thiab monocytes rau amplifycov txheej txheem inflammatorythiab pab txhawb tus kab mob mus ntxiv (Daim duab 1). Muab cov keeb kwm yav dhau los tshwj xeeb hauv txhua tus qauv kab mob, cov tshuab ntawm CCL7 yuav tsum tau tshawb xyuas tag nrho kom ntseeg tau tias kev txhais lus rau kev sim tshuaj. Qee qhov kev tshawb fawb yav dhau los tau qhia txog qhov muaj txiaj ntsig zoo ntawm CCL7 inhibition los ntawm kev cuam tshuam cov tshuaj tiv thaiv kab mob lossis cov noob caj noob ces hauv myocardial infarction, atherosclerosis, aortic aneurysm, mob raum raug mob, thiab tom qab theem ntawm unilateral ureteral obstruction [27, 29, 42, 69, 72]. Txawm li cas los xij, tam sim no tsis muaj lub hom phiaj tshuaj lossis cov tshuaj me me tiv thaiv CCL7. Vim muaj ntau qhov sib txawv ntawm cov chemokines thiab lawv cov receptors, kev sim ntxiv thiab kev tshawb fawb soj ntsuam yuav tsum tau nthuav dav kom tsom mus rau cov txheej txheem ncaj qha los tiv thaiv CCL7 raws li kev cog lus kho mob rau kev txo qis.kev loj hlob ntawm cov kab mob plawv DM, thiabkab mob raum.

Cov ntaub ntawv

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8. Grassia G, Maddaluno M, Guglielmotti A, Mangano G, Biondi G, Mafa P, Ialenti A. Cov tshuaj tiv thaiv kab mob binder inhibits neointima tsim nyob rau hauv ob leeg nas thiab hyperlipidaemic nas. Cardiovasc Res. 2009; 84(3): 485–93.

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