Cistanche tuaj yeem pab tiv thaiv kev laus?

Kev tshawb fawb nce qib ntawm kev tiv thaiv kev laus ntawm cistanche

Hu rau:joanna.jia@wecistanche.com/ WhatsApp: 008618081934791

Liu Jing

(Department of Pharmacy, Nanfang Hospital Affiliated to the First Military Medical University, Guangzhou 510515, Guangdong)

Ntsiab lus:cistanche, anti-aging, cistanchetubulosa, raum-tonifying, tiv thaiv kab mob, laus.

cistanchedeserticola YCMa yog lub qia nqaij nrog nplai nplooj ntawm Orobanchaceae cogcistanche, tseem hu ua Dayun, Longongrong, Rousongrong, Goblin, Golden Xyoob.

cistanchemuaj cov haujlwm ntawmtonifyingtusraum, filling essence, thiab nourishing ntshav. Indications ntawm txiv neej impotence. Poj niam infertility, qhov chaw mos tawm, ntshav vau, lub duav txias thiab lub hauv caug mob, ntshav qhuav, thiab cem quav. Nyob rau hauv xyoo tas los no, cov koom haum tshawb fawb tshawb fawb tau lees paub qhovanti-agingnyhuv ntawmcistanche. Tus sau ua ib qho kev tshuaj xyuas ntawm kev tshawb fawb ntawmcistanchentawmanti-aging.

1. cuam tshuam rau lub neej ntawm cov txiv hmab txiv ntoo yoov

Cistanchemuaj qhov cuam tshuam loj rau lub neej ntawm cov txiv hmab txiv ntoo yoov. Ntxiv 1 feem pua ​​​​, 5 feem pua ​​, thiab 10 feem pua ​​​​(cov tshuaj tsis zoo) ntawmcistanchemus rau qhov nruab nrab tsawg, thiab pawg tswj hwm tsuas yog qhov nruab nrab tsawg xwb.

Cov txiaj ntsig: Lub neej ntev tshaj plaws ntawm cov txiv hmab txiv ntoo yoov nyob rau hauv peb pawg kho mob ♂: 70d, 74d, 75d, ‍♀71d, 73d, 76d, thiab siab dua li pawg tswj hwm: ‍♂66d, ‍♀65d,

Ib nrab hnub tuag: ♂60.25d, 61.00d, 62.00d, ♀: 60.50d, 61.45d, thiab 62.25d, kuj siab dua pawg tswj hwm ♂: 58.75d, ♀ 58.50d, ncua ntev nruab nrab lub neej expectancy, qhov sib txawv tseem ceeb (P<0 .05‚=""><0.01)>

Cistanchepabanti-aging.

2. Qhov cuam tshuam rau kev vam meej ntawm nas

Txiv neej nas hnyav 20-40g tau muab faib ua plaub pawg, thiab ob pawg tshuaj tau muab ob homcistanchedecoction. 0.02ml/g (txhua ml yog sib npaug rau 1g crude tshuaj), nruam 14d. Qhov hnyav ntawm cov nas nyob rau hauv pawg tshuaj tau nce ntau. Piv nrog rau pawg tswj, pab pawg nrogcistanche, pawg nrogcistanchesalina, thiab pab pawg nrogcistanchetubulosayog txhua tus muaj qhov sib txawv tseem ceeb (P<0.01,><0.01,><0.05). the="" tolerance="" oxygen="" capacity="" was="" also="" significantly="" better="" than="" that="" of="" the="" control="" group=""><0.01,><0.01,><0.05). the="" weight-bearing="" swimming="" time="" was="" significantly="" prolonged=""><0.01,><0.01,>< 0.05).="" taking="">cistanche0.5ml·d-1 tshwm sim los ntawm cortisone hauv nas nrog "Yang Deficiency" kuj muaj qhov hnyav nce ntxiv (P<0.01), and="" significantly="" prolonged="" the="" freezing="" resistance="" time=""><0.01), and="" was="" able="" to="" improve="" the="" signs="" of="" "yang="" deficiency"="" in="" mice="" [2].="" results="" the="" swimming="" time="" of="" mice="" in="" the="" 20,="" 40g·kg-1="" (crude="" drug)="" administration="" group="" was="" significantly="" longer="" than="" that="" of="" the="" model="" group="" (p＜0.05‚="" p＜0.01).="" the="" freezing="" time="" was="" significantly="" higher="" than="" that="" of="" the="" model="" group="" (p＜0.01).="" 01)="" "the="" survival="" time="" of="" anti-hypoxia="" at="" normal="" pressure="" increased="" significantly"="" compared="" with="" the="" control="" group="" (p=""><0.05, p=""><0.01) [3].="" experiments="" showed="" that="">cistanchemuaj cov nyhuv ntawm kev ncua lub neej ncua ntawm nas. Thiab tseem tuaj yeem ua kom ntev lub peev xwm ciaj sia ntawm nas nrog "Yang deficiency" thiab kev puas tsuaj dawb radical nyob rau hauv ib puag ncig hnyav.

cistanchetxhim kho covtiv thaiv kab mobua haujlwm rauanti-aging.

3. Kev cuam tshuam rau lubtiv thaiv kab mobqhov system

Nrog lub hnub nyoog, lubtiv thaiv kab mobkev ua haujlwm ntawm cov neeg laus tsis muaj zog thiab tsis zoo, tshwj xeeb tshaj yog cov T hlwb ua haujlwm tau txo qis [4]. Saib xyuas cov teebmeem ntawmcistanchentawm kev tsim ntawm E rosettes thiab -naphthyl acetate (ANAE) kev ua haujlwm hauv tib neeg cov qog ntshav qog ntshav. Qhov qis concentration ntawmcistanchedecoction (5 mg · ml^-1) tuaj yeem nce Ea rosette tus nqi ntawm tib neeg peripheral ntshav lymphocytes (P＜0.05)'Tab sis nws tsis cuam tshuam rau Et rosette tus nqi.

Lub siab concentration (50mg·ml-1) inhibits tus nqi ntawm Ea thiab Et rosettes (P<0.01). both="" high="" and="" low="" concentrations="" of="">cistanchetuaj yeem txo qhov feem pua ​​​​ntawm ANAE ntxiv rau lymphocytes [5]. Gavage nas nrog 50mg·kg^-1thiab 100 mg · kg^-1dej extract. Ob pawg koob tshuaj tau nce qhov hnyav ntawm tus po thiab thymus (P<0.01 and=""><0.05). the="" delayed="" hypersensitivity="" (dth)="" in="" mice="" sensitized="" to="" sheep="" red="" blood="" cells="" (srbc)=""><0.01) is="" increased,="" significantly="" increased="" the="" number="" of="" lymphocytes="" infiltrated="" in="" the="" peripheral="" blood="" of="" mice,="" and="" the="" effect="" was="" enhanced="" with="" the="" increase="" in="" dose.="" increase="" the="" plaque-forming="" cell="" (pfc)="" value=""><0.01), and="" the="" hemolysin="" value="" is="" higher="" than="" the="" control="" group=""><0.05,><0.01). increase="" the="" phagocytic="" percentage="" of="" peritoneal="" macrophages="" (p=""><0.05) and="" the="" phagocytic="" index=""><0.01). increase="" the="" content="" of="" camp="" in="" macrophages="" (p=""><0.01), decrease="" the="" content="" of="" cgmp=""><0.01), and="" significantly="" increase="" the="" ratio="" of="" camp/cgmp="" (p=""><0.01), which="" may="" enhance="" macrophages="" one="" of="" the="" mechanisms="" of="" phagocytosis="">

Cistanchecov txiaj ntsig rauanti-aging.

4. Qhov cuam tshuam rau kev puas tsuaj dawb radical thiab lwm yam enzymes

Nyob rau hauv xyoo tas los no, cov kev tshawb fawb tau pom tias cov lipid peroxidation ntawm cov kab mob lom los ntawmkev lausthiab cov dawb radicals yog ze ze rau kev puas tsuaj ntawm cov qauv membrane thiab inactivation ntawm lub zog. Raws li ib txwm muaj, cov superoxide feem ntau yog tshem tawm los ntawm SOD. Thaum muaj hnub nyoog nce, SOD kev ua haujlwm ntawm lubkev lauslub cev txo qis, antioxidants txo qis, thiab dawb radical puas yam (OFR-MDA) nce [7'8], ua rau lub cevkev laus. Txhawm rau soj ntsuam kev sib raug zoo ntawm kev laus thiab dawb radicals thiab lwm yam enzymes, d-galactose-induced ntxov ntxovkev lauspawg qauv thiab pawg thawj coj ua rau muaj kev puas tsuaj dawb radical (0.9 ×10-2O3 concentration).

Cov txiaj ntsig: Kev nce ntawm monoamine oxidase (MAO-B) kev ua haujlwm hauv lub hlwb ntawm cov nas nyob rau hauv ob pawg ntawm 20 thiab 40 g / kg tau inhibited (P＜0.05′ P 0.01). Plasma, hlwb, thiab daim siab cov ntaub so ntswg tau dhau-lipidized oxide (LPO) txo qis (P<0.01) [3].="" 2.5,="" 12.5,="">^-1 (tus nqi ntawm cov tshuaj crude)cistancheCov tshuaj aqueous tuaj yeem ua rau muaj txiaj ntsig zoo rau SOD kev ua haujlwm ntawm nas cov qe ntshav liab (P<0.05,><0.05,><0.01), significantly="" reduce="" the="" content="" of="" myocardial="" lipofuscin="" [1].="">Cistanchedecoction 80mg · (kg·d)^-1(12 feem pua ​​​​ntawm cov tshuaj decoction) txuas ntxiv rau cov nas rau 30 hnub. Cov qe ntshav liab membrane Na plus -K plus -ATP enzyme ua haujlwm tau nce ntxiv (P＜0.01'n=6). Tej zaum nws yuav yog ib qho ntawm cov txheej txheem ntawm cov nyhuv tonic [9].

5. cuam tshuam rau kev sib deev muaj nuj nqi thiab monoamines

Txo kev ua haujlwm ntawm kev sib deev yog ib qho tseem ceeb ntawm lub cevkev laus. Cov decistancheglycosides A thiab C muaj nyob hauvcistanchemuaj antagonistic cuam tshuam rau kev kawm thiab kev sib deev dysfunction ntawm txiv neej nas. Cov echinacea muaj nyob rau hauv nws muaj ib tug antagonistic nyhuv ntawm kev sib deev tsis ua hauj lwm. Cistanche tuaj yeem txhim kho luteinizing muaj nuj nqi ntawm hypothalamus-pituitary-ovary thiab txhim kho cov lus teb ntawm pituitary rau luteinizing hormone-tso hormone thiab cov lus teb ntawm zes qe menyuam rau luteinizing hormone [10'11].cistanche(cov tshuaj crude lg/d) tuaj yeem nce norepinephrine (NA) hauv nas (P<0.01) and="" make="" adrenaline="" (a)="" drop="" back=""><0.05).>cistancheethanol extract (100'20Omg·kg-1, ob zaug ib hnub twg) tuaj yeem nce NA cov ntsiab lus ntawm hypothalamus. Cov pab pawg noj tshuaj ntau tau pom qhov sib txawv tseem ceeb hauv kev nce hauv NA (P<0.01), which="" is="" significant="" for="" the="" da/dopac="" ratio="" elevating="" effect=""><0.05), so="" that="" the="" level="" of="" the="" striatum="" (da)/dopac,="" na="" showed="" an="" upward="" trend="" [13].="" therefore,="">cistanchethiab nws cov cawv extract tuaj yeem txhim kho pituitary-gonad muaj nuj nqi los ntawm kev cuam tshuam cov ntsiab lus ntawm monoamine neurotransmitters hauv lub hlwb, yog li ncua sijhawm.kev laus.

Cistanchetxhim kho kev sib deev muaj nuj nqi thiab zoo rauanti-aging.

6. Cov nyhuv ntawm cov protein thiab nucleic acid synthesis

cistanchecuam ​​tshuam rau qhov txo qis thiab nce siab ntawm daim siab thiab spleen nucleic acid cov ntsiab lus ntawm "Yang deficiency" thiab "Yin deficiency" tsiaj. Nws tuaj yeem nce DNA synthesis tus nqi ntawm daim siab thiab tus po nyob rau hauv nas nrog "Yang deficiency" tshwm sim los ntawm hydroxyurea, txhawb RNA synthesis, thiab nce protein Metabolism ntawm nucleic acid ua rau cov nas nce phaus. Tsis muaj qhov sib txawv tseem ceeb ntawm pawg tswj hwm tsis tu ncua. Lub mechanism yuav yog li ntawdcistanchemuaj cov tshuaj lom neeg lom neeg uas ua kom muaj nucleotide reductase [14, 15].cistanchedecoction 3g·kg-1 (15 feem pua ​​decoction) tuaj yeem tiv thaiv cov protein decomposition tshwm sim los ntawm qhov hnyav-kev tawm dag zog hauv nas. Serum urea nitrogen (BUN) cov ntsiab lus qis dua (P<0.05, n="">

Cistanchezam hluav taws xob thiab siv rauanti-aging.

Xaus

Kev lausyog ib txwm physiological txheej txheem ntawm tib neeg lub cev. Cov kev hloov physiological ntawmkev lauscuam ​​tshuam rau ntau qhov system ntawm tag nrho lub cev. Ua rau cov kab mob metabolic ntawm lub cev, ua rau lub cev tsis ua haujlwm ntawm ntau lub cev, thiab ua rau cov txheej txheem kev laus ntxiv.cistanchemuaj ib tug tsawg-concentration li thiab high-concentration inhibition ntawmtiv thaiv kab mobkev ua haujlwm.cistanchetuaj yeem txhim kho kev sib deev ua haujlwm los ntawm kev cuam tshuam cov ntsiab lus ntawm monoamine neurotransmitters hauv lub cev, txhim kho kev ciaj sia nyob rau hauv ib puag ncig hnyav, thiab tshem tawm ntau heev.kev lausKev nce ntawm cov dawb radicals hauv cov tsiaj yuav txhim khu kev tiv thaiv hauv lub cev (SOD, thiab lwm yam). Hauv luv luv,cistanchetuaj yeem tiv thaiv kev puas tsuaj ntawmkev lausyam rau lub cev los ntawm ntau txoj hauv kev kom ua tiav covanti-agingnyhuv.

Nyob rau hauv xyoo tas los no, kev tshawb fawb ntawm cov khoom xyaw nquag ntawmcistanchetau tsim kho sai heev. Nws tau raug pov thawj tiascistanchemuaj kev cuam tshuam rau kev kawm thiab kev ua haujlwm ntawm kev sib deev, muaj kev cuam tshuam rau kev sib deev tsis zoo [10],anti-agingeffect [17]. Yog li ntawd, lubanti-agingnyhuv ntawmcistancheyog ze ze rau nws ntau yam active khoom xyaw. Kev tshawb fawb ntxiv ntawm nws cov khoom xyaw tseem ceeb heev rau kev txhim kho thiab txhawb nqacistancheraws li cov khoom noj qab haus huv.

Cov ntaub ntawv:

[1] Han Lichun, Hou Jinfeng, Ji Zhihua. Kev tshawb nrhiav kev tshawb fawb ntawm covanti-agingnyhuv ntawmcistanche］J. Shanghai Journal of Traditional Chinese Medicine, 1990, (11): 22∙

[2] "Zhang Yong, Wu Huan, Wang Shunian, thiab lwm yam." Kev sib piv ntawm cov teebmeem ntawm peb homcistancheraunoj zaub movraumthiab yang [J]. Tuam Tshoj Journal of Chinese Materia Medica, 1994, 19(3): 169∙

[3] Sun Yun, Lin Annian, Zhang Hongquan. Tshawb nrhiav hauv Xinjiangcistanchetiv thaiv dawb radical puas ］J］. Tuam Tshoj Journal of Chinese Materia Medica, 1994, 19(7): 433∙

[4] Zhu Yanhui. Kev siv tshuaj kho lipid-txo cov tshuaj ］J］. Phau ntawv Journal of Integrated Traditional Chinese and Western Medicine, 1989, (3): 183∙

[5] Li Baiqing, Jiang Guichen, Xu Yanping, thiab lwm yam. Kawm txog cov nyhuv ntawmLub raum- tonifyingSuav Tshuaj ntawm Cellular Immunity Ι 'Txoj Cai ntawm Xianling spleen thiabcistanchentawm tib neeg lymphocyte E rosette tsim thiab acidic -acetate. Kev cuam tshuam ntawm enzyme [J]. Phau ntawv Journal of Bengbu Medical College, 1995, 10(3): 163∙

[6] "Zhang Hongquan, Zhang Aixiang. Thaiv Niansheng. Cov nyhuv ntawmcistanchentawmtiv thaiv kab mobkev ua haujlwm ntawm nas ］J］. Middle Journal of Integrated Western Medicine, 1988, 8(12): 736∙

[7] Zhu Hanmin, Wang Zanshun. Superoxide dismutase hauv kev tshawb fawb ntawmkev lausmechanism ［J Cov tshuaj txawv teb chaws · Geriatrics Section 1985, (2): 49∙

[8] Wu Weikang. Kev muaj hnub nyoog nce ntxiv cuam tshuam rau cov concentration ntawm oxygen dawb radicals, kev ua haujlwm superoxide dismutase, thiab kev ua haujlwm ntawm myocardium hauv cov nas. Suav Journal of Gerontology, 1994, 14(4): 221∙

[9] Ding Strong, Li Shuli, Polygonatum, thiab lwm yam • Rau hom tshuaj tonic ntawm nas erythrocyte membrane Na＋－K＋＋＋＋＋＋＋＋＋＋＋＋＋＋＋＋＋＋＼

[10] "Sato Tiao" Txoj kev tshawb fawb tshuaj ntawmcistanchelos yog segmental cuam tshuam rau kev ntxhov siab ntev ntawm tus cwj pwm kev sib deev thiab kev kawm tus cwj pwm ntawm cov nas overloaded ［J］. Cov tshuaj txawv teb chaws, suav tshuaj thiab suav tshuaj Volume, 1987; 8(16): 33∙

[11] Li Bing, Yu Yunchu. Cov teebmeem ntawmraum-tonifyingcov tshuaj ntawm kev ua haujlwm ntawm hypothalamus-pituitary-gonad axis [J]. Phau ntawv Journal of Traditional Chinese Medicine, 1984; (7): 63∙

[12] Chen Mingdao, Kuang An, Chen Jiawei, thiab lwm yam tshuaj yang ntawm cortisone nas qauv hypothalamic monoamine Kev tshawb fawb ntawm lub luag hauj lwm ntawm neurotransmitters ［J］∙ Phau ntawv Journal of Integrated Traditional Suav thiab Western Tshuaj, 1990∙ 10(5): 292∙

[13] Xie Jihong, Wu Chunfu, Gao Jiao Fu, thiab lwm yam. Cov nyhuv ntawmcistancheEthanol extract ntawm monoamines nyob rau hauv nas hlwb Cov nyhuv ntawm neurotransmitter zoo li qib ］∙ Suav tshuaj ntsuab tshuaj ntsuab, 1993, 24 (8): 417∙

[14] Liu Fuchun, Ding Guangxi, Li Juxian · Epimediumcistanchentawm "Yang Deficiency" tsiaj deprivation tshwm sim los ntawm hydroxyl gland Lub luag hauj lwm ntawm oxyribonucleic acid synthesis tus nqi J］∙ Phau ntawv Journal ntawm Integrated tsoos suav thiab Western tshuaj, 1984, 4 (8): 488∙

［15］He Jiayan∙ Kev tshawb fawb nce ntxivanti-agingntawm tsoos suav tshuaj thiab nws kev koom ua ke ntawm tsoos suav thiab western tshuaj ［J］∙TCM cov ntaub ntawv

Cov ntaub ntawv 1987 (2): 21∙

, lwm.