Cov ntaub ntawv hauv tebchaws Askiv qhia tias qhov sib txawv ntawm Cystatin C thiab Creatinine EGFR muaj feem cuam tshuam rau kev pheej hmoo ntawm cov kab mob plawv!

Kev tshawb fawb tsim

Cov ntaub ntawv piv txwv British Biobank yog ib txoj kev tshawb fawb loj uas muaj ntau dua 500, 000 cov neeg koom los ntawm 2006 txog 2010. Lub hnub nyoog ntawm cov neeg mob muaj hnub nyoog li ntawm 37 txog 73 xyoo. Cov txheej txheem suav nrog rau txoj kev tshawb no yog ntsuas ntawm creatinine thiab cystatin C qib thiab tsis muaj kev kuaj mob yav dhau los ntawm lub plawv tsis ua haujlwm.

Nyem rau Cistanche rau mob raum

Txoj kev tshawb no feem ntau tsom rau tus neeg mob qhov sib txawv ntawm eGFR (eGFR diff), xam raws li cystatin C eGFR rho tawm creatinine eGFR. Raws li eGFR qhov sib txawv tus nqi, nws muab faib ua pawg tsis zoo (<-15 mL/min/1.73㎡), no significant difference group (between -15~15ml/min/1.73㎡), and a positive value group (≥15mL/min/ 1.73㎡). In addition, the researchers also analyzed eGFR diff per 10 mL/min/1.73㎡ increase as a continuous variable.

Lub ntsiab lus kawg ntawm txoj kev tshawb no yog qhov tshiab-pib atrial fibrillation, txhais tau tias paub tseeb tias atrial fibrillation hauv txhua qhov chaw kho mob. Cov ntsiab lus kawg tau raug ntsuas los ntawm thawj qhov kev mus ntsib mus txog rau thaum pib ntawm atrial fibrillation, kev tuag ntawm cov neeg koom nrog, lossis kev mus ntsib zaum kawg.

Kev tshawb fawb tshwm sim

Tom qab kev tshuaj ntsuam, tag nrho ntawm 363,494 tus neeg koom tau suav nrog hauv txoj kev tshawb no. Lawv lub hnub nyoog nruab nrab yog 56.2 ± 8.1 xyoo, 52.7% yog poj niam, thiab qhov nruab nrab eGFR txawv yog -0.6 ± 13.2ml / min / 1.73㎡. Qhov nruab nrab cystatin C eGFR thiab creatinine eGFR yog 90.1 ± 16.0 ml / min / 1.73㎡ thiab 90.7 ± 13.2 ml / min / 1.73㎡ feem. Qhov feem pua ​​​​ntawm cov neeg koom hauv pawg tus nqi tsis zoo thiab pawg tus nqi zoo yog 13.5% (n=48899) thiab 10.3% (n=37635) raws li.

Piv nrog rau cov pab pawg tsis zoo thiab tsis muaj qhov sib txawv tseem ceeb, cov neeg koom nrog hauv pab pawg muaj txiaj ntsig zoo yog cov hluas, muaj feem ntau ntawm cov poj niam, tsis haus luam yeeb, thiab ua haujlwm tsis tu ncua. Nyob rau tib lub sijhawm, lawv cov kab mob sib xws, xws li ntshav siab, ntshav qab zib, kab mob plawv, plawv tsis ua haujlwm, mob stroke, thiab lwm yam, kuj tseem tsawg dua li ntawm ob pawg. Tsis tas li ntawd, cov neeg koom nrog hauv pab pawg zoo tau txo qis lub cev qhov ntsuas (BMI), txo cov ntshav siab, qib HDL cov roj (cholesterol) siab dua, thiab qis qis ntawm cov ntshav triglycerides, LDL cov roj cholesterol, thiab siab C-reactive protein.

Tom qab kev soj ntsuam nruab nrab ntawm 11.7 xyoo, 5.2% (n=18,994) ntawm cov neeg koom tau kuaj pom tias muaj AF tshiab (xws li: 4.46/1,000 tus neeg-xyoo), suav nrog 4 ,003 (8.2%) thiab 13,796 (xws li: 4.46/1,000 neeg-xyoo). 5. Hauv kev txheeb xyuas ntau yam hloov kho rau cov teeb meem tsis sib haum xeeb, piv nrog cov pab pawg tsis muaj qhov sib txawv tseem ceeb, qhov cuam tshuam tsis zoo (sHR) ntawm pawg tsis zoo thiab pawg tus nqi zoo yog 1.25 (95% CI, 1.20~ 1.30) thiab 0.81 (95% CI, 1.20-1.30), feem. Ib., 0.77–0.87).

Hauv kev txheeb xyuas qhov sib txawv tsis tu ncua, sHR yog 0.90 rau txhua txhua 10ml / min / 1.73m2 nce hauv eGFR qhov sib txawv.

Hauv kev txheeb xyuas pab pawg, tsis hais tus neeg mob poj niam txiv neej, hnub nyoog (Ntau dua lossis sib npaug li 65 lossis<65 years), BMI (≥25kg/㎡ or <25kg/㎡), proteinuria, hypertension and diabetes, heart failure occurred in the positive group. The risks are lower than those of the no significant difference group, while the negative value group is higher than the no significant difference group.

kev sib tham tshawb fawb

Tam sim no, ob lub tswv yim yuav piav qhia txog kev sib koom ntawm eGFR qhov txawv thiab qhov pheej hmoo ntawm atrial fibrillation. Ua ntej tshaj plaws, cov kev tshawb fawb yav dhau los tau pom tias qhov piv ntawm cystatin C eGFR rau creatinine eGFR<0.6 indicates that the renal clearance rate of medium-sized molecules is reduced, which can lead to the accumulation of medium-sized molecules in the body, such as proteins that promote atherosclerosis and inflammation, and Lead to the occurrence of heart failure. Secondly, both cystatin C and creatinine levels can be affected by non-renal factors. Loss of muscle mass, advanced age, and reduced physical activity can cause creatinine levels to decrease, resulting in creatinine eGFR levels lower than true glomerular filtration rate (GFR); thyroid function, inflammation, and obesity can also affect cystatin C levels, making the Its level is lower than the true GFR. In the SPRINT study and the Cardiovascular Health Study, negative eGFR diff was generally associated with frailty in older adults. Other studies have confirmed that negative eGFR diff values are also associated with lower muscle mass, total mass, and functional status in older adults. These are all risk factors for atrial fibrillation.

Rau cov neeg mob CKD, eGFR txawv kuj tseem ceeb heev. Nws paub zoo tias kab mob plawv yog qhov ua rau tuag rau cov neeg mob CKD. Hauv CRIC txoj kev tshawb fawb, qhov tsis zoo eGFR qhov sib txawv tau cuam tshuam nrog lub plawv tsis ua haujlwm hauv cov neeg mob CKD thiab kuj tseem cuam tshuam nrog kev pheej hmoo ntawm cov teeb meem plawv plawv loj (MACE) thiab kev loj hlob ntawm coronary artery calcification. Ntxiv mus, hauv cov neeg mob uas tsis yog CKD, cov cai saum toj no tseem muaj nyob.

Zuag qhia tag nrho, qhov kev tshawb fawb no qhia tau hais tias eGFR qhov txawv tuaj yeem kwv yees qhov kev pheej hmoo ntawm lub plawv tsis ua haujlwm hauv cov neeg laus hnub nyoog noj qab haus huv, thiab cov kws tshawb fawb qhia tias cov kev tshawb fawb zoo sib xws yuav tsum tau ua rau cov neeg mob CKD kom muaj kev pheej hmoo ntau dua ntawm cov kab mob plawv hauv CKD. Cov ntsuas ntsuas.

Cistanche kho mob raum li cas?

Cistancheyog ib hom tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho ntau yam mob, suav nrograumkab mob. Nws yog muab los ntawm qhuav stems ntawmCistanchedeserticola, ib tsob nroj nyob rau hauv cov suab puam ntawm Tuam Tshoj thiab Mongolia. Lub ntsiab active Cheebtsam ntawm cistanche yogphenylethanoidglycosides, echinacoside cov tshuaj, thiabacteoside, uas tau pom tias muaj txiaj ntsig zoo rau lub raum kev noj qab haus huv.

Kab mob raum, tseem hu ua kab mob raum, hais txog ib yam mob uas lub raum ua haujlwm tsis zoo. Qhov no tuaj yeem ua rau muaj cov khoom pov tseg thiab cov co toxins hauv lub cev, ua rau muaj ntau yam tsos mob thiab teeb meem. Cistanche tuaj yeem pab kho mob raum ase los ntawm ntau lub tswv yim.

Ua ntej, cistanche tau pom tias muaj cov nyhuv diuretic, txhais tau tias nws tuaj yeem ua rau cov zis ntau ntxiv thiab pab tshem tawm cov khoom pov tseg ntawm lub cev. Qhov no tuaj yeem pab txo lub nra ntawm lub raum thiab tiv thaiv kev tsim cov co toxins. Los ntawm kev txhawb nqa diuresis, cistanche kuj tseem tuaj yeem pab txo qis ntshav siab, ib qho teeb meem ntawm cov kab mob raum.

Ntxiv mus, cistanche tau pom tias muaj cov teebmeem antioxidant. Kev ntxhov siab oxidative, tshwm sim los ntawm qhov tsis sib xws ntawm kev tsim cov dawb radicals thiab lub cev tiv thaiv antioxidant, ua lub luag haujlwm tseem ceeb hauv kev mob raum. ies pab neutralize dawb radicals thiab txo Oxidative kev nyuaj siab, yog li tiv thaiv lub raum los ntawm kev puas tsuaj. Cov phenylethanoid glycosides pom hauv cistanche tau tshwj xeeb hauv kev tshem tawm cov dawb radicals thiab inhibiting lipid peroxidation.

Tsis tas li ntawd, cistanche tau pom tias muaj cov nyhuv anti-inflammatory. Kev mob yog lwm yam tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov kab mob raum. Cistanche's anti-inflammatory zog pab txo cov zus tau tej cov pro-inflammatory cytokines thiab inhibit qhov ua kom o yuav tsum tau txoj kev, yog li alleviating o nyob rau hauv lub raum.

Tsis tas li ntawd, cistanche tau pom tias muaj cov teebmeem immunomodulatory. Hauv kab mob raum, lub cev tiv thaiv kab mob tuaj yeem ua rau tsis zoo, ua rau muaj kev mob ntau dhau thiab cov ntaub so ntswg puas. Cistanche pab tswj lub cev tiv thaiv kab mob los ntawm kev hloov kho kev tsim khoom thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li T hlwb thiab macrophages. Txoj cai tiv thaiv kab mob no pab txo qhov mob thiab tiv thaiv kev puas tsuaj ntxiv rau lub raum.

Ntxiv mus, cistanche tau pom los txhim kho lub raum kev ua haujlwm los ntawm kev txhawb nqa kev tsim kho ntawm lub raum hlab nrog cov hlwb. Lub raum tubular epithelial hlwb ua lub luag haujlwm tseem ceeb hauv kev pom thiab rov nqus cov khoom pov tseg thiab electrolytes. Hauv kab mob raum, cov hlwb no tuaj yeem raug puas tsuaj, ua rau lub raum ua haujlwm puas. Cistanche lub peev xwm los txhawb kev tsim kho ntawm cov hlwb no pab kho lub raum kom zoo thiab txhim kho lub raum tag nrho.

Ntxiv nrog rau cov kev cuam tshuam ncaj qha rau lub raum, cistanche tau pom tias muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev hauv lub cev. Txoj hauv kev zoo rau kev noj qab haus huv no tseem ceeb tshwj xeeb hauv cov kab mob raum, vim tias tus mob feem ntau cuam tshuam rau ntau lub cev thiab lub cev. che tau pom tias muaj kev tiv thaiv rau lub siab, lub plawv, thiab cov hlab ntsha, uas feem ntau cuam tshuam los ntawm kab mob raum. Los ntawm kev txhawb nqa kev noj qab haus huv ntawm cov kabmob no, cistanche pab txhim kho lub raum tag nrho thiab tiv thaiv kev mob ntxiv.

Hauv kev xaus, cistanche yog cov tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho mob raum. Nws cov active Cheebtsam muaj diuretic, antioxidant, anti-inflammatory, immunomodulatory, thiab regenerative teebmeem, uas pab txhim kho lub raum ua haujlwm thiab tiv thaiv ob lub raum los ntawm kev puas tsuaj ntxiv. , cistanche muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev, ua rau nws txoj hauv kev zoo rau kev kho mob raum.