Anti-Fatigue Effect Of Green Tea Polyphenols (-)-Epigallocatechin-3 Gallate (EGCG)
Mar 20, 2022
Yu-song Teng, Di Wu
Tsev kawm ntawv ntawm Physical Education, Liaoning Normal University, Dalian, PR Tuam Tshoj
Yog xav paub ntxiv:ali.ma@wecistanche.com
TSAB NTAWV
Keeb kwm: (-)-Epigallocatechin-3-gallate (EGCG) yog qhov ntau tshaj ntawm cov tshuaj yej ntsuab polyphenols uas nthuav tawm ntau yam bioactivities. Lub hom phiaj ntawm txoj kev tshawb no yog los soj ntsuam covanti- nkees nyhuvntawm EGCG los ntawm kev ua luam dej yuam kev. Cov ntaub ntawv thiab cov txheej txheem: Cov nas tau muab faib ua ib pawg tswj hwm thiab peb pawg EGCG-kho. Pab pawg tswj hwm tau muab cov dej distilled thiab EGCG-kho cov pab pawg tau muab tshuaj sib txawv ntawm EGCG (50, 100, thiab 200 mg / kg) los ntawm qhov ncauj gavage rau 28 hnub. Hnub kawg ntawm qhov kev sim, qhov yuam kev ua luam dej tau ua thiab ntsuas qhov ntsuas biochemical sib xws. Cov txiaj ntsig: Cov ntaub ntawv tau pom tias EGCG ua rau lub sijhawm ua luam dej ntev ntev, txo qis cov ntshav lactic acid, ntshav urea nitrogen, ntshav creatine kinase, thiab malondialdehyde, uas tau ua ke los ntawm kev nce siab hauv daim siab thiab cov leeg nqaij glycogen, thiab superoxide dismutase, catalase. , thiab glutathione peroxidase kev ua ub no. Cov ntsiab lus: Txoj kev tshawb no qhia tias EGCG muaj ib qhotiv thaiv qaug zognyhuv.
Ntsiab lus: Epigallocatechin-3-gallate, tiv thaiv qaug zog, biochemical tsis, yuam ua luam dej, nas
Taw qhia
Kev qaug zog, txhais tau tias yog lub cev thiab / lossis kev puas siab puas ntsws uas tshwm sim los ntawm kev tawm dag zog, yog qhov tsis muaj peev xwm ua kom muaj kev tawm dag zog ntxiv ntawm tib lub zog nrog kev ua haujlwm tsis zoo hauv kev ua haujlwm.[1]Kev qaug zogtuaj yeem faib ua theem nrab, physiologic, lossis ntev. Secondaryqaug zogtshwm sim los ntawm kev ntxhov siab pw tsaug zog, kev nyuaj siab, kev tawm dag zog ntau dhau, thiab cov tshuaj phiv tshuaj.Physiological qaug zogyog tshwm sim los ntawm kev so tsis txaus, kev siv zog ntawm lub cev, lossis kev mob hlwb.[2] Kev qaug zog ntev los yog ua rau qaug zog tuaj yeem cuam tshuam rau tus neeg ua haujlwm. Tsis tas li ntawd, kev qaug zog ntev ntev tuaj yeem ua rau Karoshi (tuag vim yog kev ua haujlwm ntau dhau).[3] Thaum lub sij hawm ua kom lub cev muaj zog, cov pa oxygen mus rau cov leeg pob txha pob txha nce, uas ua rau txhim kho kev tsim khoom thiab tsub zuj zuj ntawm cov pa oxygen ntau dhau (ROS).[4] Leakage ntawm electrons los ntawm mitochondrial electron thauj saw, xanthine oxidase cov tshuaj tiv thaiv, hemoglobin oxidation, thiab activated neutrophils tau raug txheeb xyuas raws li qhov tseem ceeb ntawm intracellular ROS tiam thaum lub sij hawm qoj ib ce.[5] Kev sib sau ntawm ROS yuav ua rau lub cev nyob rau hauv lub xeev ntawm oxidative kev nyuaj siab thiab tej zaum yuav ua rau raug mob rau lub cev los ntawm kev tawm tsam loj molecules thiab cell organ, ua rau lub cev qaug zog.[6]
Cov kev tshawb fawb yav dhau los kuj tau qhia tias exogenousantioxidantslos ntawm kev noj zaub mov cuam tshuam nrog endogenous antioxidants los tsim kev koom tes antioxidant network, tiv thaiv kev tawm dag zog vim oxidative kev nyuaj siab thiab txo qislub cev qaug zoglos ntawm kev khawb cov dawb radical thiab ROS.[7] Cov tshuaj yej ntsuab, ua los ntawm cov nplooj qoob loo ntawm Camellia sinensis uas tau dhau los ua oxidation tsawg, tau dav siv los ua ib qho dej haus thiab tshuaj nyob rau ntau lub teb chaws ntawm Asia, suav nrog Tuam Tshoj, Nyiv, Thaib, thiab Nyab Laj.[8] Cov tshuaj yej ntsuab tau ua pov thawj tias muaj txiaj ntsig lom neeg, xws li kev tiv thaiv kab mob qog noj ntshav, kab mob plawv, hniav lwj, rog rog, ntshav qab zib mellitus, thiab txhim kho lub cev tiv thaiv kab mob.[9] Cov txiaj ntsig zoo ntawm cov tshuaj yej ntsuab tau ntseeg tias yuav kho los ntawm nws cov polyphenols, uas yuav suav txog li 30 feem pua ntawm cov tshuaj yej ntsuab qhuav qhov hnyav.[10] Cov tshuaj yej ntsuab polyphenols feem ntau suav nrog (-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC), (-)-epicatechin (EC), (-)-epicatechin gallate (ECG), thiab catechin . Cov polyphenol ntau tshaj plaws hauv cov tshuaj yej ntsuab yog EGCG, uas tau pom tias muaj bioactivities xws li antioxidant, anticancer, anti-obesity, antibacterial, hepatoprotective, neuroprotective, thiab lwm yam.anti- nkees nyhuvntawm EGCG tam sim no paub. Yog li ntawd, qhov kev tshawb fawb tam sim no tau tsim los ntsuas qhovanti- nkees nyhuvntawm EGCG los ntawm kev yuam ua luam dej ntawm nas.
Kev sim tsim
Tom qab ob lub lis piam ntawm acclimation, tsiaj tau muab faib ua plaub pawg, txhua tus muaj 12 nas. Tswj (C) pawg: tsiaj tau muab tshuaj nrog dej distilled (1.5 mL) los ntawm qhov ncauj gavage ib hnub ib zaug rau 28 hnub. Cov tshuaj EGCG-kho qis (LET) pab pawg: tsiaj tau muab tshuaj nrog EGCG tov (50 mg / kg lub cev qhov hnyav) los ntawm qhov ncauj gavage ib hnub ib zaug rau 28 hnub. Middle-dose EGCG-kho (MET) pab pawg: tsiaj tau muab tshuaj EGCG (100 mg / kg lub cev qhov hnyav) los ntawm qhov ncauj gavage ib hnub ib zaug rau 28 hnub. High-dose EGCG-kho (HET) pawg: tsiaj tau muab tshuaj EGCG (200 mg / kg lub cev qhov hnyav) los ntawm qhov ncauj gavage ib hnub ib zaug rau 28 hnub. EGCG tov yog npaj los ntawm dissolving nws nyob rau hauv 1.5 mL ntawm distilled dej. Lub cev hnyav tau ntsuas ib zaug ib lub lim tiam. Tom qab 28 hnub, qhov yuam kev ua luam dej tau ua thiab cov khoom siv biochemical xws li BLA, SUN, SCK, cov ntaub so ntswg glycogen, SOD, GPx, thiab MDA raug ntsuas los ntawm cov khoom siv tsim nyog.
Kev quab yuam ua luam dej
Ib teev tom qab kev kho mob zaum kawg, qhov yuam kev ua luam dej tau ua raws li tau piav qhia yav dhau los nrog qee qhov kev hloov kho. 25 ± 2 degree) mus rau qhov tob ntawm 30 cm. Lub tshuab ntxhua khaub ncaws hlau (7 feem pua ntawm lub cev hnyav) tau thauj khoom ntawm tus Tsov tus tw ntawm txhua tus nas. Kev qaug zog tau txiav txim siab thaum cov tsiaj tsis tuaj yeem nyob hauv qab dej rau 10 s. Lub sijhawm ua luam dej tag nrho tau siv los ua qhov ntsuas ntawm kev ua haujlwm siab ntev.
Kev soj ntsuam ntawm biochemical tsis
Tom qab qhov kawg ntawm kev yuam kev ua luam dej, cov nas uas qaug zog tau muab txi los ntawm decapitation nyob rau hauv ether anesthesia, thiab tom qab ntawd cov ntshav tau sau thiab centrifuged (3,000} × g, 15 min) rau kev txiav txim siab ntawm BLA, SUN, thiab SCK. Cov nqaij ntshiv, lub siab, lub siab, thiab cov leeg pob txha pob txha raug muab tshem tawm thiab ntxuav hauv cov dej khov nab kuab patted qhuav. Tom qab ntawd cov spleens, lub siab, thiab daim siab tau raug ntsuas thiab lawv qhov hnyav piv rau qhov kawg ntawm lub cev qhov hnyav (organ index) raug xam. Lub siab thiab hind-limb skeletal leeg tau homogenized hauv Tris-HCl tsis, tom qab ntawd cov homogenates tau centrifuged (4, 000 × g, 20 min, 4 degree) thiab cov ntshiab supernatant tau siv rau kev txiav txim siab ntawm glycogen, SOD, GPx, CAT, MDA. Txhua qhov kev ntsuas biochemical tau txiav txim siab siv cov khoom siv tshuaj ntsuam xyuas kev lag luam raws li cov chaw tsim khoom cov lus pom zoo.
Kev txheeb cais
Kev txheeb xyuas txheeb cais tau ua tiav siv SPSS 13.0 statistical software. Cov txiaj ntsig tau qhia tias txhais tau tias ± SD. Cov tub ntxhais kawm qhov t-test tau siv rau ob pawg sib piv. Kev sib piv ntau pawg tau ua los ntawm ib-txoj kev ANOVA ua raws li Tukey qhov kev xeem rau kev soj ntsuam tom qab hoc. Qhov muaj txiaj ntsig zoo P < 0.05="" tau="" suav="" tias="" yog="" qhov="" tseem="">
TSEEM CEEB
Cov teebmeem ntawm (-)-epigallocatechin-3-gallate ntawm lub cev qhov hnyav thiab cov khoom nruab nrog cev ntawm cov nas
Raws li pom nyob rau hauv Table 1, thaum lub sij hawm kev sim, lub cev nyhav, lub siab Performance index, lub plawv Performance index, thiab spleen Performance index ntawm LET, MET, thiab HET pawg tsis txawv ho ntau npaum li cov pawg C (P > 0. 05), uas txhais tau hais tias EGCG tsis cuam tshuam rau lub cev qhov hnyav thiab qhov hnyav ntawm lub cev.
Qhov cuam tshuam ntawm (-)-epigallocatechin-3-gallate ntawm lub sijhawm ua luam dej ntawm cov nas
Raws li pom hauv daim duab 1, piv nrog pawg C, lub sij hawm ua luam dej tag nrho ntawm LET, MET, thiab HET pawg tau ntev dua (P < 0.05).="" piv="" nrog="" rau="" pab="" pawg="" let,="" lub="" sijhawm="" ua="" luam="" dej="" tag="" nrho="" ntawm="" met="" thiab="" het="" pawg="" tau="" ntev="" dua="" (p=""><0.05). cov="" nyhuv="" ntawm="">
Epigallocatechin-3-gallate ntawm Qee Cov Ntshav Biochemical Parameters Qib ntawm nas
Raws li pom hauv daim duab 2, piv nrog rau pawg C, BLA thiab SUN theem ntawm LET, MET, thiab HET pawg, nrog rau qib SCK ntawm pawg MET thiab HET, tau qis dua (P < {{1}="" }="" 05).="" piv="" nrog="" rau="" pab="" pawg="" let,="" bla="" qib="" ntawm="" met="" thiab="" het="" pawg,="" nrog="" rau="" qib="" hnub="" ci="" thiab="" sck="" ntawm="" pawg="" het,="" tau="" qis="" dua="" (p=""><>
Cov teebmeem ntawm (-)-epigallocatechin-3-gallate ntawm daim siab thiab nqaij glycogen cov ntsiab lus ntawm cov nas
Raws li pom hauv daim duab 3, piv nrog rau pawg C, lub siab glycogen cov ntsiab lus ntawm LET, MET thiab HET pawg, nrog rau cov leeg nqaij glycogen ntawm MET thiab HET pawg, tau ntau dua (P < 0="" 05).="" piv="" nrog="" rau="" pawg="" let,="" cov="" ntsiab="" lus="" glycogen="" ntawm="" met="" thiab="" het="" pawg,="" nrog="" rau="" cov="" leeg="" glycogen="" cov="" ntsiab="" lus="" ntawm="" het="" pawg,="" tau="" nce="" siab="" dua="" (p=""><>
Cov nyhuv ntawm (-)-epigallocatechin-3-gallate ntawm superoxide dismutase kev ua ub no hauv daim siab thiab cov leeg ntawm nas
Raws li pom hauv daim duab 4, piv nrog pawg C, SOD cov dej num hauv lub siab thiab cov leeg ntawm LET, MET, thiab HET pawg tau ntau dua (P < 0.05).="" piv="" nrog="" rau="" pab="" pawg="" let,="" sod="" cov="" dej="" num="" hauv="" daim="" siab="" ntawm="" met="" thiab="" het="" pawg,="" nrog="" rau="" cov="" haujlwm="" sod="" hauv="" cov="" leeg="" ntawm="" het="" pawg,="" tau="" ntau="" dua="" (p=""><>
Cov nyhuv ntawm (-)-epigallocatechin-3-gallate ntawm glutathione peroxidase kev ua ub no hauv daim siab thiab cov leeg ntawm nas
Raws li pom hauv daim duab 5, piv nrog rau pawg C, GPx cov haujlwm hauv cov leeg ntawm LET, MET thiab HET pawg, nrog rau cov haujlwm GPx hauv daim siab ntawm pawg MET thiab HET, tau ntau dua (P < {{="" 1}}="" {3}}5).="" piv="" nrog="" rau="" pawg="" let,="" gpx="" kev="" ua="" ub="" no="" hauv="" daim="" siab="" ntawm="" pawg="" het,="" nrog="" rau="" cov="" haujlwm="" gpx="" hauv="" cov="" leeg="" ntawm="" met="" thiab="" het="" pawg,="" tau="" ntau="" dua="" (p=""><>
Cov txiaj ntsig ntawm (-)-epigallocatechin-3-gallate ntawm catalase cov haujlwm hauv daim siab thiab cov leeg ntawm nas
Raws li pom hauv daim duab 6, piv nrog rau pawg C, CAT cov dej num hauv lub siab thiab cov leeg ntawm LET, MET, thiab HET pawg tau siab dua (P < 0.05).="" piv="" nrog="" rau="" pawg="" let,="" cat="" cov="" dej="" num="" hauv="" lub="" siab="" thiab="" cov="" leeg="" ntawm="" met="" thiab="" het="" pawg="" tau="" nce="" siab="" dua="" (p=""><>
Cov nyhuv ntawm (-)-epigallocatechin-3-gallate ntawm malondialdehyde qib hauv daim siab thiab cov leeg ntawm nas
Raws li pom nyob rau hauv daim duab 7, piv nrog rau pawg C, MDA qib hauv daim siab ntawm LET, MET thiab HET pawg, nrog rau cov qib MDA hauv cov leeg ntawm MET thiab HET pawg, tau qis dua (P < {{ 1}}.05).
Piv nrog rau pawg LET, MDA qib hauv daim siab ntawm pawg HET, nrog rau qib MDA hauv cov leeg ntawm MET thiab HET pawg, tau qis dua (P < 0.05).
Kev sib tham
Txoj kev tshawb fawb tam sim no tsom los ntsuas qhov kev tiv thaiv kev qaug zog ntawm EGCG. Ib qho kev ntsuas ncaj qha ntawm kev tiv thaiv kev qaug zog yog qhov nce hauv kev ua haujlwm siab ntev. Kev quab yuam ua luam dej, uas yog kab tias yog ib qho ntawm feem ntau siv tsiaj qauv ntawm kev coj tus cwj pwm poob siab, tau siv dav rau kev ntsuam xyuas ntawm cov khoom tiv thaiv kev qaug zog ntawm cov khoom sib txuas tshiab.[14] Lwm txoj hauv kev ntawm kev quab yuam xws li lub cev muaj zog treadmill lossis lub log tuaj yeem ua rau tsiaj raug mob thiab tej zaum yuav tsis ua raws li niaj hnub siv.[15] Hauv txoj kev tshawb no, cov ntaub ntawv qhia tau hais tias EGCG ua rau lub sijhawm ua luam dej ntawm nas, uas qhia tau tias EGCG muaj kev tiv thaiv kev qaug zog. Kev tawm dag zog ua luam dej tau paub tias yuav ua rau qee cov ntshav biochemical tsis muaj feem cuam tshuam txog kev qaug zog, suav nrog BLA, SUN, thiab SCK. Lactic acid yog glycolysis khoom ntawm carbohydrates nyob rau hauv ib qho kev mob anaerobic, thiab glycolysis yog lub ntsiab lub zog rau kev tawm dag zog hnyav hauv lub sijhawm luv luv.[16] Ntau cov kev tshawb fawb tau pom tias kev ua luam dej rau kev qaug zog ua rau muaj qhov nce siab ntawm cov ntshav lactic acid, thiab tus nqi ntawm cov lactic acid accumulates hauv cov ntshav tau pom qhov cuam tshuam rov qab rau lub sijhawm ua luam dej.[17] Tsis tas li ntawd, qhov nce ntxiv ntawm lactic acid ua rau txo qis ntawm pH hauv cov leeg nqaij thiab cov ntshav, thiab ua rau lub npe hu ua acidosis, ua rau muaj kev qaug zog. Yog li, BLA yog qhov ntsuas qhov ntsuas ntawm qhov qaug zog. Hauv txoj kev tshawb no, cov ntaub ntawv tau qhia tias EGCG txo qis BLA qib ntawm cov nas, ua kom muaj txiaj ntsig ntawm BLA nce thiab ncua qhov tshwm sim ntawm lub cev qaug zog. SUN yog qhov kawg-cov khoom ntawm cov protein metabolism thiab kuj yog qhov ntsuas ntawm cov protein metabolism hauv lub cev. Thaum so, tiam thiab excretion ntawm SUN nyob rau hauv equilibrium, thaum tom qab tag nrho ua luam dej, SUN kom meej meej nce nyob rau lub sij hawm no.[18] Muaj kev sib raug zoo ntawm urea nitrogen hauv vivo thiab kev ua haujlwm siab ntev.[6] Yog li, SUN yog lwm qhov ntsuas qhov ntsuas ntawm qhov qaug zog.
Hauv txoj kev tshawb no, cov ntaub ntawv tau qhia tias EGCG txo qis SUN qib ntawm cov nas, uas qhia tias EGCG tuaj yeem txo cov protein metabolism thiab txhim kho kev ua haujlwm siab. Serum creatine kinase (SCK) yog ib qho chaw kho mob biomarker rau cov nqaij ntshiv kev puas tsuaj thiab ib qho kev qhia tsis ncaj ntawm kev puas tsuaj ntawm daim nyias nyias.[19] Kev ua haujlwm ntawm creatine kinase muaj qhov cuam tshuam ntau dua rau qhov tshwm sim hauv cov leeg nqaij puas. Thaum lub sij hawm tus txheej txheem ntawm cov leeg degeneration, cov leeg hlwb lyse, thiab lawv cov ntsiab lus raug tso tawm rau hauv cov hlab ntsha. Vim hais tias feem ntau ntawm cov creatine kinase nyob rau hauv lub cev ib txwm muaj nyob rau hauv cov nqaij ntshiv, ib tug nce nyob rau hauv cov ntshav theem ntawm creatine kinase qhia tau hais tias cov nqaij ntshiv puas tau tshwm sim los yog twb pib lawm.[20] Kev tso tawm ntawm creatine kinase rau hauv cov ntshav yog qhov tshwm sim ntawm kev nce permeability ntawm cell membrane vim lipids peroxidation.[21] Hauv txoj kev tshawb no, cov ntaub ntawv tau qhia tias EGCG txo qis SCK qib ntawm cov nas, ua kom cov leeg nqaij puas tsuaj los ntawm kev tawm dag zog tas li. Nws tuaj yeem suav hais tias qhov kev hloov pauv no ua rau EGCG txhim kho kev ua haujlwm siab ntev. Khaws glycogen nyob rau hauv cov ntaub so ntswg yog lub hauv paus ntawm lub zog thaum lub sij hawm kev tawm dag zog vim cov leeg tsis tuaj yeem txav cov rog sai li glycogen thiab fatty acids tsis tuaj yeem metabolized anaerobically.[22] Nws yog qhov paub zoo tias qhov depletion ntawm glycogen hnyav txwv tsis pub lub zog thiab lub zog tso zis ntau tshaj plaws. Lub zog rau kev tawm dag zog yog pib los ntawm kev tawg ntawm cov leeg glycogen, tom qab kev tawm dag zog hnyav tuaj yeem ua tiav thiab tom qab theem, lub zog yuav tau muab los ntawm daim siab glycogen.[23] Lub siab glycogen depletion tej zaum yuav yog ib qho tseem ceeb hauv kev txhim kho ntawm kev qaug zog vim tias lub siab glycogen depleted thaum lub sij hawm qoj ib ce tsis muaj peev xwm tswj tau cov ntshav qabzib, thiab qhov ua rau hypoglycemia tuaj yeem ua rau lub paj hlwb tsis zoo. [24] Yog li ntawd, glycogen cia ncaj qha cuam tshuam rau kev tawm dag zog lub cev thiab ua kom cov glycogen cia ua kom muaj peev xwm ua kom muaj peev xwm thiab locomotor muaj peev xwm.[25] Hauv txoj kev tshawb no, cov ntaub ntawv tau qhia tias EGCG ua rau lub siab thiab cov leeg nqaij glycogen ntau ntxiv ntawm cov nas, uas qhia tau tias EGCG tuaj yeem txhim kho kev ua haujlwm ntev. Tej zaum nws yuav yog vim EGCG tau txhawb nqa glycogenolysis tswj thiab / lossis gluconeogenesis.
Txawm li cas los xij, muaj kev sim ua pov thawj qhia tias kev tawm dag zog ntau tuaj yeem ua kom lub zog triglyceride (lossis rog), tom qab ntawd ua kom cov roj fatty acids dawb tso rau hauv plasma. ua rau txo qis ntawm glycogen depletion tus nqi thiab kev txhim kho kev ua haujlwm siab ntev. Yog li, xav tau kev sim ntxiv txhawm rau txhawm rau txheeb xyuas cov txheej txheem los ntawm EGCG tuaj yeem cuam tshuam rau kev rog rog. Muaj pov thawj tias ROS tshaj li qhov qub physiological coping ntau yam thaum lub sij hawm tag nrho kev tawm dag zog, tsub zuj zuj ntawm ROS thiab txo nyob rau hauv antioxidant raws li txoj cai yuav tshwm sim.[30] Qhov xwm txheej no nce oxidative kev nyuaj siab thiab ua rau lipid peroxidation thiab oxidative hloov pauv ntawm cov protein thiab DNA.[31] Cov antioxidant enzymes xws li SOD, CAT, thiab GPx tej zaum yuav muaj lub luag haujlwm tseem ceeb hauv kev txo cov tshuaj lom ntawm ROS, thiab kev txhim kho hauv kev ua haujlwm antioxidant enzyme tuaj yeem pab tiv thaiv kev qaug zog.[6] Txawm li cas los xij, ntau cov kev tshawb fawb tau qhia txog qhov txo qis hauv kev ua haujlwm antioxidant enzyme tom qab kev tawm dag zog tas li, [32] thiab kev txo qis hauv cov tshuaj tiv thaiv antioxidant enzyme tej zaum yuav tshuav rau lawv siv tawm tsam cov dawb radicals thiab lawv inhibition los ntawm hom dawb radicals.
Hauv txoj kev tshawb no, cov ntaub ntawv tau qhia tias EGCG tau nce ntau ntxiv SOD, CAT, thiab GPx cov haujlwm ntawm nas, uas qhia tau tias EGCG muaj peev xwm los tswj cov kev ua haujlwm antioxidant enzyme los tiv thaiv oxidative stress-induced los ntawm kev tawm dag zog, rov txhawb tias EGCG muaj. ib qho tshuaj tiv thaiv qaug zog. Lipid peroxidation sawv cev rau oxidative cov ntaub so ntswg puas los ntawm hydrogen peroxide, superoxide anions, thiab hydroxyl radicals, ua rau cov txheej txheem hloov ntawm daim nyias nyias, tso tawm ntawm tes thiab organelle cov ntsiab lus, thiab poob ntawm cov fatty acids tseem ceeb nrog tsim cytosolic aldehyde thiab peroxide khoom. ] MDA, ib qho metabolite ntawm phospholipid peroxidation, yog ib qho kev ntsuas nrov ntawm thawj tus mob ntawm lub cev oxidative puas tsuaj.[34] Hauv txoj kev tshawb no, cov ntaub ntawv tau qhia tias EGCG txo qis MDA qib ntawm cov nas, uas qhia tau tias EGCG tuaj yeem txo cov lipid peroxidation thiab txo qis kev tawm dag zog ua rau oxidative puas tsuaj. Nyob rau hauv xyoo tas los no, qee cov kws tshawb fawb tau sim los kawm txog kev tiv thaiv kev qaug zog ntawm cov tshuaj yej ntsuab extract thiab ntsuab tshuaj yej polyphenols. Yus et al. [35] pom tias cov tshuaj yej ntsuab haus cov ntsiab lus tuaj yeem ua rau lub sijhawm ua luam dej, txo qis lactate acid, thiab nce cov ntsiab lus ntawm daim siab glycogen. Liang et al. [36] qhia tias Yunnan ntsuab tshuaj yej extract txo lub sij hawm ua luam dej thiab txhim kho daim siab thiab cov leeg nqaij glycogen ntsiab lus. Fan et al. [37] pom tias ntsuab tshuaj yej polyphenols extract tuaj yeem ua kom ntev lub sijhawm ua luam dej, uas pom tau tias ntsuab tshuaj yej polyphenols extract muaj cov nyhuv los tiv thaiv qaug zog. Murase et al. [38] tshawb xyuas qhov cuam tshuam ntawm catechin-nplua nuj ntsuab tshuaj yej extract (GTE) ntawm kev ua haujlwm siab thiab lub zog metabolism thaum lub sijhawm ua haujlwm hauv BALB / c nas thiab pom tias qhov kev ua kom muaj zog-txhim kho ntawm GTE tau kho, tsawg kawg ib nrab, los ntawm kev muaj peev xwm metabolic. thiab siv cov fatty acid ua lub zog ntawm cov leeg pob txha thaum lub sijhawm ua haujlwm.
Huang et al. [39] pom tias EGCG tuaj yeem txuas ntxiv lub sijhawm nce toj, lub sijhawm ua luam dej tas mus li, lub sijhawm khiav lub log, thiab lub sijhawm muaj sia nyob ntawm hypoxia kam rau cov nas, nrog rau kev ua kom cov LDH ntau ntxiv thiab MG thiab LG cov ntsiab lus, tab sis txo qis BLA thiab BUN. cov ntsiab lus. Sachdeva et al. [40] tau tshaj tawm tias kev kho mob ntev nrog EGCG tau rov qab zoo tag nrho cov kev coj cwj pwm tsis zoo nrog rau kev ntxhov siab thiab hyperalgesia nyob rau hauv cov nas uas tsis muaj zog txaus nyob rau hauv koob tshuaj. Tanaka et al. [41] qhia tias EGCG muaj txiaj ntsig zoo rau kev ua kom qaug zog. EGCG muab qhov ncauj zoo li muaj cov nyhuv antioxidant ntawm lub siab oxidatively puas ntawm cov tsiaj rog. Hauv txoj kev tshawb no, peb kuj pom tias EGCG ua rau lub sijhawm ua luam dej ntev ntev thiab txo qis ntawm BLA, SUN, SCK, thiab MDA, uas tau nrog kev nce ntxiv hauv daim siab thiab cov leeg nqaij glycogen, thiab SOD, CAT, thiab GPx cov dej num. Yog li ntawd, cov txiaj ntsig tam sim no txhawb ntxiv tias EGCG muaj cov txiaj ntsig los tiv thaiv kev qaug zog ntawm kev siv tshuaj thiab ntawm koob tshuaj 200 mg / kg tau nthuav tawm cov txiaj ntsig zoo. Ua ke nrog cov kev tshawb fawb yav dhau los, cov txheej txheem tiv thaiv kev qaug zog ntawm EGCG tej zaum yuav yog vim nws qhov kev tiv thaiv ntawm lub cev nqaij daim nyias nyias los ntawm kev tiv thaiv lipid oxidation los ntawm kev hloov kho ntawm ntau yam kev ua haujlwm antioxidant enzyme.[42] Txoj kev tshawb fawb ntxiv no tau lees paub los piav qhia nws cov txheej txheem molecular thiab kev tiv thaiv kev qaug zog ntsig txog noob. Qhov kev tshawb pom ntawm txoj kev tshawb fawb qhia tias EGCG tuaj yeem siv los tsim cov tshuaj nutraceutical los pab txhawb kev rov qab los ntawm kev qaug zog thiab txo qis kev tawm dag zog ua rau oxidative puas tsuaj.
Cistanche tubulosa ntau npaum, Nyem daim duab kom paub ntau ntxiv!
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