Kev soj ntsuam thiab kev xav txog ntawm daim ntawv thov patent Los ntawm Nyiv Hanbaku Cov Tuam Txhab Tshuaj Hauv Xyoo Xyoo dhau los: Case Of Tsumura Pharmaceutical Thiab Kracie Ⅱ

2.2.3 Cov Txheej Txheem Kev Tshawb Fawb

Nyob rau hauv 2012, Tsumura Pharmaceutical tau tsim tsib patents ntawm fingerprinting (FP) (Fingerprint, FP) patents nyob rau hauv 2012 kom pab tau computerized Cov patents tau tsim nyob rau hauv 2012 kom pab tau computerized ntsuam xyuas ntawm tag nrho cov zoo ntawm Han formula npaj thiab zoo ntawm ntau yam tshuaj. . Lawv yog Cov no: cov qauv thiab ntau yam tshuaj ntsuam xyuas cov khoom [38]; tsim ntawm FP program thiab ntaus ntawv uas muaj cov ntaub ntawv peb sab [39]. cov ntaub ntawv [39]; ib lub cuab yeej los tsim cov kev pabcuam FP thiab cov khoom siv uas muaj cov ntaub ntawv peb sab [40]; ib qho cuab yeej kom ua tiav qhov tseeb ntawm txhua qhov ncov ntawm lub hom phiaj qauv raws li qhov siab tshaj ntawm cov qauv siv [41]. Cov cuab yeej muaj tseeb ntawm txhua qhov ncov ntawm cov qauv siv [40]; cov ntaub ntawv sib sau ua ke (piv txwv li, kua chromatography, roj av chromatography, NMR spectroscopy, thiab lwm yam) thiab cov txheej txheem kev soj ntsuam zoo sib xws thiab cov khoom siv [41]. Cov txheej txheem kev soj ntsuam zoo sib xws thiab cov cuab yeej siv rau cov ntaub ntawv sib xyaw (xws li kua chromatography, roj chromatography, NMR spectroscopy, thiab lwm yam) [41]; cov txheej txheem kev soj ntsuam thiab cov cuab yeej siv rau kev sib piv thiab ntsuas cov qauv sib xyaw ua ke ntawm cov qauv, FP cov yam ntxwv sib xyaw ua ke, thiab FP cov yam ntxwv sib xyaw ua ke [42]. Cov txheej txheem kev soj ntsuam thiab cov cuab yeej siv rau kev sib piv thiab ntsuas cov yam ntxwv sib xyaw ua ke ntawm cov qauv thiab cov yam ntxwv sib xyaw ua ke ntawm FP [42]. Cov txheej txheem kev soj ntsuam thiab cov cuab yeej siv no tuaj yeem txhim kho cov txheej txheem thiab cov cuab yeej txuas ntxiv tuaj yeem txhim kho kev ntseeg tau thiab qhov tseeb ntawm multicomponent tshuaj ntsuam xyuas qhov zoo Cov txheej txheem kev soj ntsuam thiab cov cuab yeej siv rau kev tshuaj xyuas cov khoom siv ntau yam tuaj yeem txhim kho kev ntseeg tau thiab qhov tseeb ntawm multicomponent tshuaj ntsuam xyuas zoo thiab ua kom cov kev soj ntsuam zoo. .

Tsis tas li ntawd, Tsumura Pharmaceutical tau thov rau patents ntawm kev npaj cov khoom lag luam rau xyoo caum dhau los [34-44]. Tsis tas li ntawd, Tsumura Pharmaceutical tau thov rau patents ntawm kev npaj cov khoom tswj rau xyoo caum dhau los [34-44], suav nrog cov tshuaj Serpentine, Japanese Pharmacopoeia Atractylodis Macrocephalae, thiab lwm cov ntawv sau hauv Suav. Tsis tas li ntawd, Tsumura Pharmaceutical tau txuas ntxiv thov rau patents ntawm kev npaj cov kev tswj rau xyoo caum dhau los [34-44], uas suav nrog cov ntsiab lus ntawm ntau cov tshuaj Japanese rau Suav tshuaj, xws li Japanese Pharmacopoeia Hakushu compound, raws li qhia. hauv Table 2.

2.2.3 Cov Txheej Txheem Kev Tshawb Fawb

Nyob rau hauv 2012, Tsumura Pharmaceutical tau tsim tsib patents ntawm fingerprinting (FP) (Fingerprint, FP) patents nyob rau hauv 2012 kom pab tau computerized Cov patents tau tsim nyob rau hauv 2012 kom pab tau computerized ntsuam xyuas ntawm tag nrho cov zoo ntawm Han formula npaj thiab zoo ntawm ntau yam tshuaj. . Lawv yog Cov no: cov qauv thiab ntau yam tshuaj ntsuam xyuas cov khoom [38]; kev tsim ntawm FP program thiab ntaus ntawv uas muaj cov ntaub ntawv peb sab [39]. cov ntaub ntawv [39]; ib lub cuab yeej los tsim cov kev pabcuam FP thiab cov khoom siv uas muaj cov ntaub ntawv peb sab [40]; ib qho cuab yeej kom ua tiav qhov tseeb ntawm txhua qhov ncov ntawm lub hom phiaj qauv raws li qhov siab tshaj ntawm cov qauv siv [41]. Cov cuab yeej muaj tseeb ntawm txhua qhov ncov ntawm cov qauv siv [40]; cov ntaub ntawv sib sau ua ke (piv txwv li, kua chromatography, roj chromatography, NMR spectroscopy, thiab lwm yam) thiab cov txheej txheem kev soj ntsuam zoo sib xws thiab cov khoom siv [41]. Cov txheej txheem kev soj ntsuam zoo sib xws thiab cov cuab yeej siv rau cov ntaub ntawv sib xyaw (xws li kua chromatography, roj chromatography, NMR spectroscopy, thiab lwm yam) [41]; cov txheej txheem kev soj ntsuam thiab cov cuab yeej siv rau kev sib piv thiab ntsuas cov qauv sib xyaw ua ke ntawm cov qauv, FP cov yam ntxwv sib xyaw ua ke, thiab FP cov yam ntxwv sib xyaw ua ke [42]. Cov txheej txheem kev soj ntsuam thiab cov cuab yeej siv rau kev sib piv thiab ntsuas cov yam ntxwv sib xyaw ua ke ntawm cov qauv thiab cov yam ntxwv sib xyaw ua ke ntawm FP [42]. Cov txheej txheem kev ntsuam xyuas ntau yam thiab cov cuab yeej no tuaj yeem txhim kho cov txheej txheem thiab cov cuab yeej txuas ntxiv tuaj yeem txhim kho kev ntseeg tau thiab raug ntawm kev ntsuas tshuaj ntau yam zoo Cov txheej txheem kev soj ntsuam thiab cov cuab yeej rau kev tshuaj xyuas cov khoom siv ntau yam tuaj yeem txhim kho kev ntseeg tau thiab raug ntawm kev tshuaj ntsuam xyuas cov tshuaj multicomponent zoo thiab ua rau kom muaj txiaj ntsig zoo. kev ntsuam xyuas efficiency.

Tsis tas li ntawd, Tsumura Pharmaceutical tau thov rau patents ntawm kev npaj cov khoom lag luam rau xyoo caum dhau los [34-44]. Tsis tas li ntawd, Tsumura Pharmaceutical tau thov rau patents ntawm kev npaj cov khoom tswj rau xyoo caum dhau los [34-44], suav nrog cov tshuaj Serpentine, Japanese Pharmacopoeia Atractylodis Macrocephalae, thiab lwm yam.Cov ntawv sau ntawv Suav. Tsis tas li ntawd, Tsumura Pharmaceutical tau ua ntawv thov tsis tu ncua rau patents ntawm kev npaj cov kev tswj rau lub xyoo caum dhau los [34-44], uas suav nrog cov ntsiab lus ntawm ntau cov tshuaj Japanese rau Suav tshuaj, xws li Japanese Pharmacopoeia Hakushu compound, raws li qhia. hauv Table 2.

Nyem qhov no kom tau Cistanche Extract RauKev siv tshuaj

3 Kracie Pharmaceuticals Patent

Kracie Pharmaceuticals 'kev tsim cov khoom lag luam tsom rau cov tswv yim tshiab ntawm Han cov lus pom zoo uas ua tau raws li cov neeg siv khoom xav tau thiab nrhiav kev yooj yim ntawm kev siv, xws li kev siv yooj yim haus, tso cai rau ntau tus neeg siv hanbok npaj ua ib feem ntawm lawv lub neej [6], thiab pab txhawb kev tiv thaiv. ntawm ntu tam sim no tshuaj xyuas Kracie cov kev npaj Hanbok tshiab, uas tau pab txhawb kev tiv thaiv kev hloov pauv ntawm lub cev thiab kev ua haujlwm tsis zoo cuam tshuam nrog kev laus. Tshooj lus no tshuaj xyuas cov patents uas tau thov los ntawm Kracie Pharmaceuticals nyob rau hauv kaum xyoo dhau los hais txog kev txhim kho lub cev patents foob los ntawm Kracie Pharmaceuticals hauv kaum xyoo dhau los, nrog rau qee qhov kev ua tau zoo ntawm cov khoom lag luam thiab kev soj ntsuam kev ua haujlwm Tshooj no tshuaj xyuas cov ntaub ntawv pov thawj los ntawm Kracie Pharmaceuticals kawg. kaum xyoo cuam tshuam txog kev txhim kho lub cev, nrog rau qee txoj hauv kev los ntsuas qhov ua tau zoo thiab kev ua haujlwm ntawm cov khoom, xws li "cov nyhuv sov" txoj kev.

3.1 Cov txheej txheem ua haujlwm thiab cov khoom sib xyaw

Raws li thaj tsam ntawm daim ntawv thov ntawm 45 patents thov los ntawm Kracie Pharmaceuticals rau kev ua haujlwm thiab kev sib xyaw, nws cov tshuaj suav tau muab faib ua peb thaj chaw, suav nrog patents ntsig txog kev txhim kho lub neej, patents cuam tshuam txog kev tiv thaiv kab mob, thiab patents cuam tshuam txog kev tiv thaiv kev laus, suav rau 42.2 feem pua, 37.8 feem pua, thiab 20.0 feem pua, raws li (Daim duab 2).

3.1.1 Cov khoom siv txhim kho lub neej

Cov khoom lag luam no tuaj yeem muab faib ua kev txhim kho ntawm kev pw tsaug zog, kev kho mob ntawm cov dej cawv, kev tiv thaiv thiab kev kho mob ntawm kev hnov ​​​​qab, txhim kho kev kho hniav, mob thiab khaus khaus, txhim kho anorexia, txhim kho daim tawv nqaij, thiab txhim kho anorexia, txhim kho daim tawv nqaij. , thiab kev tiv thaiv thiab kev kho mob ntawm hyperuricemia thiab gout. 8 qeb.

(1) Txhim kho kev pw tsaug zog tsis zoo

Kev pw tsaug zog tsis zoo yog muaj nyob rau hauv cov neeg ntawm txhua lub hnub nyoog, thiab xyoo 2008, Kracie Pharmaceuticals, Inc. Hauv xyoo 2008, Kracie Pharmaceuticals tau tsim Docosahexae⁃noic acid (DHA) ua kev pw tsaug zog. noic acid (DHA) raws li cov khoom xyaw nquag thiab kev noj haus, tshuaj pleev ib ce thiab tshuaj muaj nws. Lub tuam txhab tau tsim ib qho kev sib xyaw ntawm docosahexae ⁃ noic acid (DHA) ua cov khoom xyaw nquag thiab kev noj haus, tshuaj pleev ib ce thiab tshuaj uas muaj nws los txhim kho kev pw tsaug zog, tshwj xeeb tshaj yog qaug zog thaum sawv [2008 (2) haus dej haus cawv.

(2) Kev noj qab haus huv dej cawv

Ntau yam khoom xyaw brewing, extracts thiab micronutrients uas muaj nyob rau hauv cawv Cov ntau yam brewing Cheebtsam, extracts, thiab micronutrients muaj nyob rau hauv cawu cub muaj kev noj haus thiab tonic nyhuv, warming lub cev thiab txhawb cov ntshav ncig. Nyob rau hauv 2013, ib daim ntawv thov rau ib yam khoom uas yuav tsum tau tsuas yog ib tug luv luv mixing lub sij hawm nyob rau hauv tsev nrog ib tug aqueous nruab nrab. Nyob rau hauv 2013, peb tau thov rau ib tug patent rau ib tug invention kom tau ib tug noj qab haus huv haus hmoov uas tsis muaj cawv tsw, zoo clarity, thiab yooj yim haus dej haus los ntawm tsuas yog muab nws nrog ib tug aqueous nruab nrab nyob rau hauv tsev rau ib lub sij hawm luv luv. Nyob rau hauv 2013, ib qho kev tsim patent [63] tau thov rau cov hmoov tshuaj kho mob cawv uas muaj ntxhiab tsw, zoo pob tshab, thiab siv yooj yim dua los ntawm cov neeg tsis zoo ntawm kev haus dej cawv. (3) Kev tiv thaiv thiab kev kho mob ntawm kev hnov ​​​​lus

(3) Tiv thaiv thiab kho cov kab mob hallucinogenic

Hauv xyoo 2015, qhov kev tsim tawm ntawm cov khoom xyaw nquag uas muaj Atractylodis Macrocephalae thiab Atractylodis Macrocephalae xws li atractylenolide II, atractylenolide III thiab atractylone, tau tsim nyob rau xyoo 2015 ua ib qho tshiab antihallucinogen uas muaj cov khoom xyaw nquag ntawm Atractylodes.

(4) Txhim kho qhov ncauj noj qab haus huv

Kev kho hniav caries thiab kab mob periodontal yog ob yam kab mob loj ntawm lub qhov ncauj kab noj hniav thiab muaj nyob rau hauv cov pej xeem, thiab gallocatechin thiab gallate ua lub luag haujlwm tseem ceeb hauv kev kho mob ntawm qhov ncauj. Txhawm rau tiv thaiv thiab txhim kho cov kab mob hauv lub cev, es tsis txhob siv cov tshuaj astringent thiab iab epigallocatechin gallate Theaflavin thiab theaflavin-based gallate tau pom tias muaj txiaj ntsig zoo tiv thaiv matrix metalloproteins, uas yog qhov ua rau cov kab mob periodontal.

Raws li inhibition ntawm matrix metalloproteinase (MMP), uas yog qhov ua rau muaj kab mob hauv lub cev, theaflavin thiab theaflavin gallate tau thov rau. (MMP), uas yog qhov ua rau muaj kab mob hauv lub cev, thiab tau ua daim ntawv thov patent rau ib qho tsw qab thiab muaj kev nyab xeeb rau tib neeg Txhawm rau tiv thaiv thiab txhim kho cov hniav caries, patent tau thov rau cov khoom xyaw thiab haus nrog cov tsw zoo thiab nyab xeeb rau tib neeg [ 65] ib.

Txhawm rau tiv thaiv kev txhim kho cov hniav caries, ib yam khoom uas muaj kev cuam tshuam zoo heev ntawm glucosyltransferase tau muab los ua ib qho kev hloov rau Kev Tiv Thaiv thiab txhim kho cov hniav caries, qhov ncauj muaj pes tsawg leeg nrog zoo heev glucosyltransferase inhibition yog muab los hloov cov astringent thiab iab epigallocatechin {{0} }zoo. Hauv xyoo 2019, qhov kev tsim kho ntawm ib qho kev txhim kho qhov ncauj kab noj hniav los ntawm kev ntxiv goji berries haus tsw ntawm mammalian placenta compositions muaj rau cov kab mob ntawm lub qhov ncauj xws li ulcer technology rau kev txhim kho saj ntawm mammalian placenta compositions muaj rau cov kab mob ntawm qhov ncauj xws li rwj los ntawm kev ntxiv wolfberry [ 67] ib.

(5) Txhim kho qhov mob thiab khaus khaus

Cov khoom xyaw nquag los ntawm cov tshuaj sib txawv los ua kom mob inhibitors thiab khaus khaus tag nrho 2 patents. Raws li: nyob rau hauv 2015, cov khoom xyaw nquag los ntawm honeysuckle paj, licorice, cinnamon bark, thiab lwm yam., uas tau soj ntsuam rau lawv lub peev xwm los inhibit Nerve growth factor (NGF)-induced dorsal root ganglion (DRG) induced los ntawm paj hlwb kev loj hlob (NGF) .

Cov nyhuv ntawm DRG ntawm dorsal cag ganglion (DRG) tshwm sim los ntawm Nerve Growth Factor (NGF) tau ua rau inhibition ntawm neuronal proliferation thiab inhibition ntawm qhov mob rhiab heev thiab mob rhiab heev vim yog thawj lub paj hlwb txuas ntxiv. Yog li ntawd, peb tau tsim cov paj hlwb protrusion inhibitor, qhov mob inhibitor, thiab khaus khaus uas tuaj yeem cuam tshuam qhov mob rhiab heev thiab khaus khaus vim yog thawj qhov kev hnov ​​​​qab txuas ntxiv. elongation inhibitor, mob inhibitor, thiab pruritus inhibitor [68]; Hauv 2016, kev tshawb fawb ntawm 2015, neuroprotection elongation inhibitor, mob inhibitor thiab pruritus inhibitor Hauv xyoo 2016, cov paj hlwb elongation inhibitor, mob inhibitor, thiab pruritus inhibitor cov tswv yim ntawm 2015 tau hloov kho [69], nrog qhov sib txawv ntawm cov khoom xyaw nquag tau muab rho tawm. los ntawm cov tshuaj nyoos sib txawv. cov khoom xyaw nquag, uas tau muab rho tawm los ntawm cherry bark, wattle, bupleurum, thiab croton tsawg kawg yog ib qho ntawm cov extracts.

(6) Kev txhim kho ntawm anorexia

Raws li kev taw qhia ntawm Suav kev kho mob txoj kev xav, 3 patents tau thov los muab kev kho mob rau anorexia nervosa, muab cov tshuaj zoo tshiab thiab kev xaiv kho mob. Xyoo 2011, muab xyoo 2011, peb tau muab ib hom tshuaj suav tshuaj nrog cov tshuaj tsw qab muab rho tawm los ntawm kev sib xyaw ntawm cov tshuaj suav tshuaj xws li qi-regulating tshuaj, tshuaj epithelial, tshuaj tua ntshav thiab tshuaj tua hluav taws kub. Ib tug muaj pes tsawg leeg nrog ib tug aroma muab rho tawm los ntawm ib tug sib tov ntawm Suav tshuaj noj tshuaj xws li qi-relieving tshuaj, tshuaj antiphlogistic, ntshav boosting tshuaj, thiab tshav kub-tshuaj tshuaj ntsuab los ntawm cov dej kub extraction txoj kev yuav txhim kho cov tsos mob xws li chim siab, kev nyuaj siab, mob taub hau, raws plab. , mob plab, thiab anorexia [70], los ntawm txoj kev ua pa los yog plab hnyuv.Nyob rau hauv 2018, muab kev tshaib plab hormone teeb liab (loj hlob hormone-tso peptide teeb liab) nrog ginseng raws li lub active ingredient teeb liab) enhancer [71], nrog rau ginseng diol, protopanaxadiol, ginseng Nyob rau hauv 2019, ib tug tshiab ginseng noj zaub mov kua zaub los ntawm ginseng (muaj Ginseng, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Atractylodes Macrocephala, Poria, thiab lwm yam) nrog rau cov khoom xyaw nquag Neuropeptide Y (NPY), uas txhawb cov calcium ntxiv hauv cov hlwb. txhawb kev tshaib plab. NPY tuaj yeem txhawb nqa calcium nkag mus rau hauv cov hlwb thiab ntxiv dag zog rau cov txiaj ntsig ntawm kev tshaib kev nqhis, muab ib qho (7) Txhim kho daim tawv nqaij

(7) Kev txhim kho ntawm daim tawv nqaij

Cov tawv nqaij yog ib qho ntawm cov kab mob loj tshaj plaws ntawm lub cev, thiab tib neeg txoj kev nrhiav kev zoo nkauj kuj mus dhau ntawm kev siv tshuaj pleev ib ce thiab tau pib tsom mus rau kev tswj hwm sab hauv. Kracie Pharmaceuticals kuj tau tsom mus rau kev txhim kho kev npaj thiab cov khoom noj hauv qhov ncauj los txhim kho cov tawv nqaij. Los ntawm 2009 txog 2017, Kracie Pharmaceuticals tsom nws cov kev tshawb fawb thiab kev tsim kho kev siv zog feem ntau ntawm kev txhim kho.

Kev sib xyaw ua ke tshiab los yog ntxiv cov inhibitors tshiab rau kev txhim kho ntawm daim tawv nqaij Tag nrho ntawm xya Suav patents [73-79] tau ua ntaub ntawv ntawm xyoo 2009 thiab 2017 rau kev txhim kho daim tawv nqaij zoo nkauj thiab tawv nqaij laus inhibition, suav nrog patents Cov thev naus laus zis tseem ceeb yog invention ntawm txawv herbal extracts raws li active cov khoom xyaw, xws li cherry bark, qhiav, mammalian Cov txheej txheem tseem ceeb ntawm lub patent yog lub invention ntawm txawv herbal extracts li active cov khoom xyaw, xws li extracts ntawm tsoos tshuaj xws li cherry bark, qhiav, thiab mammalian placenta.

3.1.2 Anti-cancer khoom

Los ntawm 2009 txog 2017, peb tau thov rau tsib hom patents, uas yog, aromatase inhibitors, kev sib txuas tshiab, cov neeg ua haujlwm tshiab, cov khoom noj tshiab thiab cov txheej txheem tshiab, cov khoom siv tshiab, cov tshuaj tshiab, cov khoom noj tshiab thiab cov txheej txheem tshiab. Los ntawm 2009 txog 2017, peb tau thov rau tsib hom patents, uas yog, aromatase inhibitors, kev sib txuas tshiab, cov neeg ua haujlwm tshiab, cov khoom noj tshiab thiab cov txheej txheem tshiab, txhawm rau txhim kho cov qog nqaij hlav muaj peev xwm ntawm cov neeg mob thiab muab cov tshuaj tshiab adjuvant rau kev kho mob ntawm cov kab mob qog noj ntshav. . Peb tau muab cov tshuaj kho tshiab adjuvant rau kev kho mob ntawm cov kab mob qog.

Aromatase yog ib qho enzyme uas hloov androgens rau hauv estrogens, uas tuaj yeem txo cov androgens lossis nce estrogen. Aromatase yog ib qho enzyme uas hloov androgens rau estrogens thiab tuaj yeem txo cov androgens lossis nce estrogen. Nws muaj txiaj ntsig zoo tsis yog rau kev kho mob qog noj ntshav hauv cov poj niam postmenopausal xwb, tab sis kuj rau cov txiv neej uas muaj mob menopausal thiab cov kab mob metabolic uas tshwm sim los ntawm visceral rog tsub zuj zuj. Nws tseem muaj txiaj ntsig zoo hauv kev tiv thaiv thiab kev kho mob ntawm kev sib deev hormone-dependent kab mob xws li metabolic syndrome tshwm sim los ntawm visceral rog tsub zuj zuj. Los ntawm 2009 txog 2014, thawj zaug, cov enzyme tau inhibited los ntawm Epimedium, Rhodiola, thiab XanthiumCornus officinalis, Rheum officinale thiab Rhizoma Dioscorea tau pom tias muaj peev xwm inhibit qhov aromatase kev ua ntawm 36 cov khoom ntuj. Lub aromatase inhibitory kev ua ub no ntawm patchouli glycosides muaj nyob rau hauv Herba Epimedium thiab silymarin muaj nyob rau hauv Silymarin tau lees paub. Tag nrho ntawm yim patents [81-88] tau thov los tsim cov tshuaj aromatase tshiab los ntawm kev hloov kho cov tshuaj epimedium thiab silymarin. Peb tau thov rau yim patents [{2}}] los tsim cov aromatase inhibitors tshiab los ntawm kev hloov tshuaj Epimedium thiab Silymarin.

Tag nrho ntawm 9 patents tau thov rau ib ncig ntawm burdock extract raws li cov khoom xyaw nquag, suav nrog peb tau thov rau 9 patents ntawm burdock extract raws li cov khoom xyaw nquag, suav nrog 5 cov tshuaj tshiab thiab cov khoom xyaw thiab 4 txheej txheem kev npaj. Lawv nyob rau hauv 2013, peb tau tsim ib tug tshiab anti-cancer tus neeg saib xyuas rau pancreatic cancer [89]; Xyoo 2014, peb tau muab cov tshuaj tiv thaiv kab mob tshiab rau kev mob qog noj ntshav pancreatic. Hauv xyoo 2014, peb tau muab cov tshuaj tiv thaiv kab mob qog noj ntshav tshiab tshiab thiab cov khoom noj ntim rau kev tiv thaiv kab mob qog noj ntshav [89]. Nyob rau hauv 2014, ib tug tshiab anticancer qia cell tus neeg sawv cev thiab ib tug ntim khoom noj rau anticancer qia cell txiav txim [90]; Xyoo 2015, ib qho tshuaj tiv thaiv kab mob tshiab uas muaj bovine Hauv xyoo 2015, tus neeg sawv cev tiv thaiv kab mob uas muaj bovine serum albumin thiab gemcitabine tau muab [91]; Hauv xyoo 2017, kev tsim kho ntawm kev siv cov khoom xyaw nquag hauv burdock extract rau random elongation ntawm cov ntshav txawv txav ntawm randomly elongated txawv txav cov hlab ntsha sib txuas, yog li txhim kho cov ntshav tsis paub tab thiab tsis muaj zog.

inhibition ntawm qhov tsim ntawm randomly elongated txawv txav cov hlab ntsha sib txuas siv cov khoom xyaw nquag los ntawm burdock extract, yog li txhim kho cov hlab ntsha tsis paub tab thiab tsis muaj zog [92]; Nyob rau hauv tib lub xyoo, ib txoj kev tau muab los txhim kho cov nyhuv ntawm hluav taws xob kho mob anticancer tus neeg sawv cev, hluav taws xob sensitizer thiab zaub mov muaj pes tsawg leeg [93]. Burdock extract Cov khoom xyaw nquag hauv burdock extract muaj ob qho tib si tshuaj tiv thaiv kab mob thiab ntau yam haujlwm xws li kev txhim kho cov ntshav txaus Cov tshuaj mammalian placenta extract kuj tseem muaj txiaj ntsig hauv inhibiting aging-induced Kracie Pharmaceuticals tau tsim ntau cov kev npaj raws li burdock extract. Kracie Pharmaceuticals tau tsim ntau qhov kev npaj raws li burdock extract, thiab tau ua plaub daim ntawv thov rau kev npaj ntawm burdock extract. Plaub daim ntawv thov raug foob rau kev npaj ntawm burdock extract. Piv txwv li, purification ntawm actinase los ntawm -glucosidase, ntxiv ntawm ethanol, thiab ziab kom tau siab Cov txheej txheem ntawm kev npaj burdock extract nrog siab myogenin ntsiab lus [94-96]; Kev npaj ntawm burdock extract nrog tshwj xeeb Cov txheej txheem ntawm kev npaj burdock extracts nrog tshwj xeeb actin ntsiab lus piv [97]

.

3.1.3 Cov khoom tiv thaiv kev laus

Kracie cov khoom rau kev tiv thaiv kev laus tuaj yeem muab faib ua peb pawg raws li lawv lub luag haujlwm: kev tiv thaiv thiab kho cov kab mob metabolic, kev tiv thaiv thiab kho dementia, thiab kev tiv thaiv thiab kho ntau yam kab mob geriatric.

(1) Kev tiv thaiv thiab kho cov kab mob metabolic

Hyperlipidemia yog ib hom kab mob metabolic uas tshwm sim ntau zaus thiab yog ib qho tseem ceeb hauv cov kab mob plawv, feem ntau pom muaj nyob rau hauv cov neeg laus thiab cov neeg laus, tab sis nrog kev hloov pauv ntawm kev noj haus thiab kev haus cawv ntau ntxiv, qhov tshwm sim ntawm cov tub ntxhais hluas kuj tseem nce xyoo los ntawm xyoo. . compound (fat absorption inhibitor) [98], thiab kev sib xyaw ua ke lossis cov khoom siv cov khoom siv no los yog cov khoom siv nrog kev tiv thaiv thiab kev ua kom zoo rau kev rog rog thiab hyperlipidemia; Hauv xyoo 2009, peb tau muab cov tshuaj inhibitors ntawm qhov nce hauv nruab nrab roj concentration hauv cov ntshav thiab nruab nrab cov roj nqus nqus inhibition nyhuv ntawm cov khoom noj haus [99].

(2) Kev tiv thaiv thiab kho dementia

Raws li txoj kev xav ntawm Suav tshuaj thiab siv cov cuab yeej siv niaj hnub no, peb tau thov rau peb daim ntawv patents ntawm Suav formulations rau kev txhim kho thiab kho dementia Lawv nyob rau hauv 2012, peb muab ib tug muaj pes tsawg leeg uas muaj ib tug dej-relieving tshuaj los yog dampness-transforming tshuaj uas. muaj txiaj ntsig zoo rau kev tiv thaiv thiab kho dementia. Nyob rau hauv 2012, ib tug muaj pes tsawg leeg thiab Suav formulation muaj ib tug dej-relieving tshuaj los yog dampness-transforming tshuaj zoo rau kev tiv thaiv thiab kho dementia [100] tau foob. Hauv xyoo 2015 thiab 2018, cov ntawv thov raug foob rau tus neeg saib xyuas kev puas siab puas ntsws uas muaj cov tshuaj tiv thaiv lub siab ntxiv rau Chen Pi thiab Panax notoginseng, raws li [101-102]. (3) Kev tiv thaiv thiab kev kho mob ntawm ntau yam kab mob geriatric

(3) Kev tiv thaiv thiab kev kho mob ntawm ntau yam kab mob geriatric

Tag nrho ntawm plaub patents raug foob rau cov qauv rau kev tiv thaiv thiab kev kho mob ntawm ntau yam kab mob geriatric, ntawm peb ntawm lawv yog cov tshuaj tiv thaiv kev tuag ntawm tes hauv qhov chaw muaj poov tshuaj siab. Peb ntawm lawv yog cov muaj pes tsawg leeg los inhibit cell tuag nyob rau hauv siab poov tshuaj ib puag ncig. compositions thiab formulations muaj Odesman sesquiterpene derivatives raws li cov khoom xyaw nquag [103], uas tuaj yeem txhim kho ntau yam kab mob ntawm cov neeg laus xws li Alzheimer's disease, cerebral infarction, angina pectoris thiab ntshav qab zib. thiab ntshav qab zib mellitus, ntawm lwm yam kab mob ntawm cov neeg laus. Nyob rau hauv tib lub xyoo, ib txoj kev tshawb no ntawm inhibition ntawm high potassium ib puag ncig

Nyob rau hauv tib lub xyoo, ob qho kev hloov kho tshiab tau ua nyob rau hauv lub teb ntawm cov compositions rau inhibition ntawm cell tuag nyob rau hauv high-potassium ib puag ncig. Cov khoom xyaw nquag hauv thawj qhov kev hloov kho tshiab yog wool sterane triterpene derivative [104 Cov khoom xyaw nquag hauv thawj qhov hloov tshiab yog woolly steroid triterpenoid derivatives [104]; Cov khoom xyaw nquag suav nrog hauv qhov hloov tshiab thib ob yog steroid A, ginsenoside Rg1, ligustrolactone, lossis ergosterol [105]. Xyoo 2020, ib qho inhibitor ntawm kev mob ntev vim kev laus tau tsim muaj cov khoom xyaw nquag xws li ethanolamine thiab mammalian placenta extracts mammalian placenta extracts, mammalian mis los yog mammalian siab rho tawm [106]. Cov khoom xyaw nquag yog ethanolamine thiab cov amino acids uas muaj nyob rau hauv mammalian placenta extracts, mammalian mis nyuj los yog mammalian siab rho tawm [106].

3.2 Cov kev ua tau zoo thiab kev ntsuas kev ua haujlwm

Kracie Pharmaceuticals tau muab ib lub hom phiaj tseem ceeb ntawm kev ntsuas qhov ua tau zoo thiab kev ua haujlwm ntawm Kracie Pharmaceuticals los ntawm kev paub tsis meej ntawm cov tsos mob, cov tsos mob, thiab lwm yam kev tshawb fawb, xws li kev tsim cov qauv tsiaj, los muab lub hom phiaj ntawm 7 txoj kev ntsuam xyuas thiab kev faib tawm, uas pab txhim kho (1) Kev ntsuam xyuas kev ua tau zoo suav nrog "kev ua tau zoo" thiab "kev ua tau zoo".

Kev ntsuas kev ua tau zoo suav nrog cov txheej txheem rau kev txiav txim siab qhov sib npaug ntawm "qi, ntshav, thiab dej" [107], kev faib tawm ntawm lub cev (1) Kev ntsuas kev ua tau zoo suav nrog txoj kev "qi, ntshav thiab dej" sib npaug [107] , cov txheej txheem ntawm kev faib tawm lub cev [108], thiab kev ntsuam xyuas txoj kev "ua kom sov" [109]. Nws tuaj yeem ntsuas lub hom phiaj thiab ntsuas qhov tseeb ntawm oxygen saturation ntawm hemoglobin, frontal thiab electrolyte concentrations nyob rau hauv lub hauv pliaj, thiab los txhim kho (2) Qib qaug zog tau suav nrog hauv kev ntsuas kev ua haujlwm.

(ii) Kev ntsuas kev ua haujlwm suav nrog kev ntsuas kev qaug zog [110], kev paub txog kev ntsuas kev ua haujlwm [111], thiab tag nrho peb txoj hauv kev. (110), thiab kev txawj ntse [111], thiab kev ntsuas ntawm hemoglobin oxygen saturation, electrolyte concentration (ii) Kev ntsuas kev ua haujlwm suav nrog ob txoj hauv kev ntsuas kev qaug zog [110] thiab kev ntsuas kev paub txog kev ua haujlwm [111], thiab kev ua kom muaj nuj nqis ntawm tib neeg kev ua haujlwm. los ntawm kev ntsuas hemoglobin oxygen saturation thiab electrolyte concentration.

(iii) Tsiaj qauv Tag nrho ntawm 2 tus qauv tsiaj tau tsim los rau kev nyuaj siab [112] thiab o [113], uas tau muab ib txoj hauv kev los ntsuas cov tshuaj tiv thaiv. (3) Tsiaj qauv rau kev nyuaj siab [112] thiab edema [113] tau tsim los muab ib txoj hauv kev los txiav txim siab cov tshuaj pharmacological thiab kev ua tau zoo ntawm cov tshuaj tiv thaiv kev ntxhov siab thiab tshuaj kho edema. (2) tsiaj qauv ntawm kev nyuaj siab [112] thiab edema [113] tau tsim los muab ib txoj hauv kev los ntsuas cov tshuaj pharmacological thiab ntsuas qhov ua tau zoo ntawm cov tshuaj tiv thaiv kev ntxhov siab thiab cov tshuaj edema.

4 Kev sib tham

4.1 Tswj cov khoom zoo thiab cov khoom zoo

Nrog rau kev muag khoom ntawm Japanese hanboks nyob rau hauv Nyiv thiab txawv teb chaws, qhov kev thov rau raw cov ntaub ntawv rau Suav tshuaj tau nce, thiab nws yog ib qho tseem ceeb kom ua tau raws li ob qho tib si cov khoom ruaj khov ntawm raw cov ntaub ntawv thov rau raw cov ntaub ntawv rau Suav tshuaj tau nce, thiab nws. Nws yog ib qho tsim nyog los ua kom tau raws li qhov ruaj khov ntawm cov khoom siv raw thiab ua kom cov khoom zoo. Nyob rau hauv xyoo tsis ntev los no, Tsumura Pharmaceutical Co. Nyob rau hauv xyoo tas los no, Tsumura Pharmaceutical Company tau nrawm tsim nws tus kheej hanbaku ua liaj ua teb thiab tab tom ua haujlwm kom ua tiav lub hom phiaj ntawm kev cog qoob loo los ntawm kev tshawb fawb ntawm cov khoom siv raw. Lub tuam txhab tau siv zog ua kom tiav 100 feem pua ​​​​ntawm kev cog qoob loo ntawm cov tshuaj nyoos los ntawm kev tshawb fawb txog kev cog qoob loo raw tshuaj [15], thiab tau nruj me ntsis txwv kev siv tshuaj tua kab. Kev siv tshuaj tua kab yog nruj me ntsis txwv, thiab kev tshawb fawb traceability yog nyob rau hauv qhov chaw. Nyob rau tib lub sijhawm, kev siv cov tshuaj tua kab uas seem seem, cov kab mob, cov hlau hnyav, thiab lwm yam kev kuaj xyuas kev nyab xeeb kom ntseeg tau tias cov khoom siv raw thiab cov tshuaj zoo tau raug lees paub los ntawm kev ua raws li kev soj ntsuam kev nyab xeeb ntawm cov tshuaj tua kab, kab mob, thiab hnyav hlau. Nws yog ib qho tseem ceeb uas nyob rau hauv kaum xyoo dhau los, Tsumura Pharmaceutical Co. Lub tuam txhab tau txuas ntxiv txhim kho nws cov txheej txheem kev soj ntsuam kom muaj nuj nqis thiab zoo, thiab tau tsim ib qho kev qhia ntau lossis kev soj ntsuam zoo tag nrho, tshwj xeeb tshaj yog kev npaj tshuaj tiv thaiv rau cov khoom xyaw nquag.

Lub tuam txhab tau txuas ntxiv thov rau ntau tus patents nyob rau hauv thaj tsam ntawm ntau qhov ntsuas los yog tag nrho cov kev ntsuam xyuas zoo, tshwj xeeb tshaj yog nyob rau hauv kev npaj cov tshuaj tiv thaiv rau cov khoom xyaw nquag. Cov tshuaj tswj kev tswj hwm zoo ntawm cov tshuaj suav Cov tshuaj tswj kev tswj hwm zoo ntawm cov tshuaj suav tshuaj yog zoo ib yam rau cov cim zoo (Q-markers) ntawm cov tshuaj suav [114] Cov tshuaj tswj kev tswj xyuas zoo ntawm cov tshuaj suav tshuaj yog zoo sib xws hauv ib feem rau Q-markers [114], uas muaj txiaj ntsig zoo rau kev tshawb fawb txog qhov zoo ntawm cov tshuaj suav tshuaj ntsuab thiab cov tshuaj suav tshuaj hauv Suav teb thiab rau kev txhim kho txuas ntxiv ntawm cov qauv kev lag luam hauv Suav tshuaj. thiab kev txhim kho txuas ntxiv ntawm kev tsim qauv hauv TCM kev lag luam.

4.2 Kev tsim cov khoom tshiab taw qhia rau tus kheej xav tau

Rau cov tuam txhab tshuaj hauv Suav teb, kev lag luam tab tom ntsib teeb meem ntawm chav me me rau kev loj hlob ntawm cov tshuaj noj, thiab qee qhov kev tshawb fawb kwv yees tias OTC cov tshuaj thiab cov khoom noj qab haus huv yuav tsum yog qhov chaw loj hlob tom ntej [15].Kracie Pharmaceuticals, uas tsom rau kev txhim kho cov neeg mob. Kev noj qab haus huv los ntawm Suav tshuaj, muaj nyob rau hauv xyoo tas los no tau thov rau Suav tshuaj formulations thiab ua ke nrog cov lus qhia dav thiab nce kev yooj yim ntawm kev siv, nrog rau

Nyob rau hauv xyoo tas los no, Kracie tau ua ntawv thov rau Hanban formulations thiab kev sib txuas nrog cov lus qhia dav dav thiab nce kev yooj yim ntawm kev siv, thiab rau txoj hauv kev los soj ntsuam qhov ua tau zoo ntawm Hanban. Nyob rau tib lub sijhawm, cov neeg siv khoom tau cia siab tias OTC Suav cov tshuaj yuav ntxiv rau lawv lub neej txhua hnub kom ntau li ntau tau. Rau ib qho kev lag luam mob siab rau kev tiv thaiv thiab kev kho mob ntawm tus kab mob, Kracie Pharmaceuticals 'lub tswv yim ntawm tib neeg-centered formulation tsim yog rau pem hauv ntej-saib, raws li nyob rau hauv Suav tshuaj thiab kev loj hlob ntawm ib tug dav ntau yam ntawm cov tshuaj.

Kracie lub tswv yim tshiab qhia tias Suav tshuaj thiab cov tuam txhab noj qab haus huv hauv Suav teb yuav tsum tsom mus rau cov kev xav tau ntawm tus kheej ntawm cov neeg siv khoom hauv kev tsim thiab tsim cov khoom tshiab, ua kom tob lub tswv yim ntawm "kho tus kab mob ua ntej nws tshwm sim" hauv Suav tshuaj, tsom rau kev tiv thaiv. thiab kho kev ua haujlwm ntawm lub cev, thiab ua tau raws li qhov xav tau ntawm tib neeg lub cev. precisely ua tau raws li qhov xav tau ntawm tib neeg lub cev ua haujlwm, thiab tsis tu ncua

Txhawm rau txhim kho qhov tseem ceeb ntawm kev sib tw ntawm peb cov khoom.

4.3 Tsim cov khoom tshiab hauv thaj chaw zoo

Hauv Nyij Pooj, cov tshuaj OTC raug cais los ntawm cov lus qhia, suav nrog 15 qhov qhia, thiab tuaj yeem tsim dawb raws li cov cai ntawm formulary.115 Kev lag luam OTC ntawm Kracie Pharmaceuticals yog tsom rau qib thib ob ntawm cov tshuaj dav dav. Cov zaub mov noj qab haus huv hauv Nyij Pooj suav nrog peb pawg ntawm cov khoom noj rau kev noj qab haus huv tshwj xeeb, cov khoom noj uas muaj npe, thiab cov khoom noj muaj txiaj ntsig zoo [116]. Qee qhov kev sau patents ntawm cov qauv tsim thiab cov khoom sib xyaw tsis tuaj yeem sib haum rau cov khoom lag luam tiag tiag, yog li lawv tsis sib haum rau OTC saum toj no lossis cov khoom noj noj qab haus huv hauv kev tshuaj xyuas.

Hauv cov neeg laus niaj hnub no, mob qog noj ntshav, mob hlwb, kab mob plawv, kab mob metabolic, thiab kab mob autoimmune tau nce zuj zus, thiab cov tshuaj muaj kev txwv hauv kev kho cov kab mob no. Los ntawm daim ntawv thov patent uas tau thov los ntawm Kracie Pharmaceuticals nyob rau hauv xyoo tas los no, nws yog qhov tseeb tias nws cov tshuaj suav siv tau zoo dua hauv qee cov kab mob ntev, thiab qhov zoo ntawm kev tsom mus rau cov neeg mob laus tau dhau los ua qhov tseem ceeb nrog kev txhim kho ntawm ntau qhov kev sib txuas tshiab thiab. cov khoom tau tsim. Tuam Tshoj cov tuam txhab tshuaj yuav tsum nquag tsim cov tuam txhab tshuaj hauv Suav teb yuav tsum nquag tsim cov khoom lag luam tshiab hauv cov chaw kho mob uas TCM muaj qhov zoo thiab koom tes nrog cov tshuaj siv tshuaj los nthuav cov kev siv tshuaj kho mob thiab kev lag luam. Lawv yuav tsum nquag tsim cov khoom tshiab TCM hauv thaj chaw kho mob uas TCM muaj qhov zoo thiab sib koom tes nrog cov tshuaj siv tshuaj los nthuav cov kev siv tshuaj kho mob thiab kev lag luam muaj peev xwm.

4.4 Nruam R & D peev thiab ntxiv dag zog patent layout

Piv txwv li, Tsumura Pharmaceutical Company tau txhim kho thiab thov rau qhov thib ob patent ntawm txoj kev npaj nruab nrab ntawm hluavtaws anthocyanin hauv ib xyoos; Kracie Pharmaceutical tuam txhab tau thov rau 8 patents ntsig txog aromatase inhibitors ib leeg, thiab tas li hloov kho nws cov peripheral patents los tsim nws nruj patent network los tiv thaiv cov neeg sib tw Kracie Pharmaceuticals tau thov yim patents rau aromatase inhibitors ib leeg. Cov tuam txhab Japanese Hanbaku nqis peev nyiaj ntau txhua xyoo hauv kev tshawb fawb ntawm Hanbaku cov khoom. Cov tuam txhab tshuaj Japanese Suav tau nqis peev nyiaj ntau txhua xyoo hauv kev tshawb fawb thiab txhim kho cov khoom lag luam hauv Suav. Raws li kev txheeb cais, hauv Nyij Pooj Hanban Japanese Hanbal cov tshuaj system, tuam txhab lag luam suav txog 60 feem pua ​​​​ntawm tag nrho cov neeg ua haujlwm tshawb fawb thiab thev naus laus zis. 60 feem pua ​​​​ntawm tag nrho cov kws tshawb fawb thiab cov neeg ua haujlwm hauv Nyij Pooj Hanbal cov tshuaj tshawb fawb thiab thev naus laus zis, thiab R & D cov nuj nqis nqis peev los ntawm cov lag luam suav txog 80 feem pua ​​​​ntawm R & D peev hauv Japanese Hanbal tshuaj [117]. 80 feem pua ​​[117]. Cov tuam txhab lag luam hauv Suav teb yuav tsum tau them nyiaj rau kev nqis peev hauv kev tshawb fawb hauv Suav tshuaj thiab txhim kho lawv lub peev xwm los ua R & D ntawm cov khoom siv tshuaj hauv Suav teb thiab hloov kho mus rau cov tuam txhab thev naus laus zis thiab kev lag luam tshuaj nrog kev ywj pheej cov cuab yeej cuab tam, thiab tsim lub teb chaws hom tshuaj suav tshuaj. hom. Nyob rau tib lub sijhawm, peb yuav tsum tau kos cov lus qhia los ntawm kev teeb tsa ntawm Japanese Hanbok patents thiab Peb yuav tsum nquag thov patents rau kev tiv thaiv kev cai lij choj, txhawm rau tiv thaiv kev txaus siab ntawm cov tuam txhab tshuaj suav zoo dua txhawm rau tiv thaiv kev nyiam ntawm cov kws tshawb fawb, cov neeg ua haujlwm thiab cov neeg siv tshuaj suav, peb yuav tsum tsim thiab tsim cov tswv yim patent rau Suav tshuaj. txhawm rau tiv thaiv kev nyiam ntawm cov kws tshawb fawb, cov neeg ua haujlwm thiab cov neeg siv TCM, thiab tsim thiab tsim ib lub tswv yim patent rau TCM-hais txog lub hauv paus ntawm kev lag luam thoob ntiaj teb yog nteg.

5 Summary and Prospect

Cov tshuaj noj tshuaj, tshuaj OTC, thiab cov khoom siv kho mob muab cov duab qhia dav dav ntawm Nyij Pooj Cov khoom lag luam ntawm Japanese suav tshuaj kev lag luam muaj kev dav. Tsumura Pharmaceutical Company yog feem ntau hauv kev lag luam tshuaj tshuaj. Lub tuam txhab tau koom nrog hauv kev lag luam tshuaj tshuaj, thiab ua haujlwm tsis tu ncua los txhim kho nws cov qauv tsim kom muaj txiaj ntsig zoo ntawm nws cov tshuaj. Peb tab tom ua haujlwm tsis tu ncua los txhim kho qhov zoo ntawm peb cov qauv tsim los ntawm kev siv cov thev naus laus zis xws li bioassays los ntsuas tag nrho cov khoom zoo ntawm peb cov khoom Hanban. Peb tseem tab tom siv zog los txhim kho lub hom phiaj ntawm kev ua tau zoo ntawm cov tshuaj suav tshuaj los ntawm kev ntsuam xyuas tag nrho cov khoom zoo siv cov thev naus laus zis xws li bioassays. Kracie Pharmaceuticals yog feem ntau hauv OTC tshuaj thiab kev noj qab haus huv kev lag luam. Kracie Pharmaceuticals feem ntau yog nyob rau hauv cov tshuaj OTC thiab kev noj qab haus huv kev lag luam, thiab nws cov patent tsom mus rau kev tsim kho ntawm Hanban formulations nrog ib tug ntau ntawm cov lus qhia thiab nce kev yooj yim ntawm kev siv. Kracie Pharmaceuticals yog feem ntau hauv OTC tshuaj thiab kev noj qab haus huv kev lag luam. Kev tshuaj xyuas ntawm daim ntawv thov patent tau thov los ntawm Japanese Hanban cov tuam txhab tshuaj hauv kaum xyoo dhau los Cov ntawv thov patent tau thov los ntawm Japanese tuam txhab tshuaj suav hauv kaum xyoo dhau los tau sau tseg, qhia txog kev xav tau rau yav tom ntej ntawm kev tsim kho tshiab ntawm Suav cov khoom lag luam thiab cov khoom lag luam patent. Kev txhim kho cov khoom tshiab thiab kev txhim kho zoo ntawm cov khoom lag luam patent yuav tsum yog raws li cov neeg siv khoom xav tau thiab kev txhim kho zoo ntawm cov khoom lag luam hauv Suav teb tshiab thiab cov chaw muag tshuaj yuav tsum ua raws li cov neeg siv khoom xav tau, kev siv cov khoom siv tshuaj suav tau zoo, kev ua kom zoo ntawm cov tshuaj suav tshuaj zoo. thev naus laus zis ntawm TCM yuav tsum tau ua kom zoo, tus qauv zoo ntawm TCM yuav tsum tau txhim kho, thiab kev txhim kho kom zoo thiab Lub ntsiab lus qhia ntawm R & D thiab kev tsim cov tshuaj suav tshuaj yog los txhim kho qhov zoo thiab kev lees paub ntawm cov neeg siv khoom, kom ua raws li kev lag luam thoob ntiaj teb thiab zoo dua qhib kev lag luam. Qhov zoo ntawm cov tshuaj suav tshuaj yuav tsum tau ua kom zoo dua qub, thiab kev tswj xyuas cov cuab yeej zoo yuav tsum tau ua kom zoo.

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