Kev laus thiab kab mob raum: Cov lus nug qub rau cov kev nyuaj tshiab

Abstract:

Mob raum mob (CKD) yog ib qho teeb meem loj zuj zus ntawm cov neeg laus, thiab cov naj npawb ntawmcov tib neeg uas muaj kev pheej hmoo ntawm cov kab mob raum kawg yog nce. Ib feem ntawm qhov laj thawj yog nyob rau hauv kev nkag siab tsis tiav ntawm txoj hauv kevhauv qab lub raum laus thiab kab mob raum, nrog rau kev xa khoom tsis txaus ntawm cov pov thawj-raws li kev kho mobrau cov neeg laus nrog CKD. Qhov kev tshuaj xyuas no yog txhawm rau daws cov teeb meem tsis daws teeb meem los ntawm delineating kho tshiab mechanismsntawm lub raum senescence thiab sau cov ntsiab lus tsis ntev los no ntawm kev kho mob tseem ceeb ntawm CKD hauv cov neeg laus.Cov teeb meem thiab teeb meem hauv kev saib xyuas cov neeg laus nrog CKD tau tham txog, nrog rau qhov tseem ceeb ntawm kev hloov khontawm kev pheej hmoo, tiv thaiv mob raum raug mob, stabilization ntawm kev loj hlob, thiab kev txiav txim siab ntawm kev pib lim ntshav.

Ntsiab lus:

laus, laus, mob raum mob, mob raum raug mob, kawg-stage raum kab mob, dialysis

Cov kab mob raum tsis zoo (CKD) tau raug lees paub ntau duantawm cov neeg laus, uas ua rau muaj qhov tseem ceebkev sib tw rau cov kws kho mob thoob ntiaj teb [1-3]. Ntau tus neeg laus raug kuaj pom muaj CKD raws li tsuas yogntawm kev poob qis kwv yees glomerular filtration rate(eGFR) [4], tab sis seb qhov no yog txheej txheem ntawm kev laus li qub lossiskab mob kev loj hlob tseem muaj teeb meem. Hauv kev tshuaj xyuas no, peb yuav xub delineate qhov sib txawv ntawm lub raum lausthiab kab mob raum, thiab piav qhia txog txoj hauv kev muaj peev xwm thiabmechanisms nyob rau hauv lub raum aging. Cov no ua rawslos ntawm kev sib tham ntawm kev tshawb pom tsis ntev los no hais txog kev kis kabmob, cov xwm txheej txaus ntshai, kev nce qib, thiab cov txiaj ntsig ntawm CKDhauv cov laus.

Yees duab: Herb Cistanche

Thaum kawg, hloov kho cov lus pom zoo txogmuaj kev saib xyuas cov neeg mob laus nrog CKD,nrog rau qhov tseem ceeb ntawm kev hloov kho ntawm cov kev pheej hmoo,tiv thaiv mob raum raug mob, stabilization ntawm lub raumkev nce qib, thiab kev txiav txim siab ntawm kev pib lim ntshav.

Table 1:Cov qauv thiab kev ua haujlwm hloov pauv ntawm lub raum laus.

Cov kev tshawb fawb txog kev noj qab nyob zoo ntawm lub raum hloov pauv cov neeg pub nyiaj muajtau muab cov ntaub ntawv tsim nyog ntawm ob qho tib si cov qauv thiabkev hloov pauv uas tshwm sim nrog kev laus li qub.Vim tias cov neeg mob lub raum tau txais kev soj ntsuam raws li kev soj ntsuam, suav nrog rau lub raum ua haujlwm thiab cov duab kawm kom paub meejnoj qab haus huv ua ntej pub dawb. Pre-implantation biopsy ntawmlub raum allograft tuaj yeem muab cov ntaub so ntswg rau lub raum rau cov qauvkev soj ntsuam. Piv txwv li, nyob rau hauv ib qho kev soj ntsuamkoom nrog 1203 tus neeg laus nyob raum pub dawb, Txoj Cai li al. pom qhov nce ntawm nephrosclerosis nrog kev laus, los ntawm 2.7 feem pua ​​​​rau cov hnub nyoog 18-29 xyoo mus rau 73 feem pua ​​​​rau cov hnub nyoog 70-77 xyoo, raws li tau txiav txim los ntawm core needle biopsy ntawm lub raum graft. Lawv pom muaj kev sib raug zoo ntawm lub hnub nyoog thiab nephrosclerosistxawm tias tom qab kho rau lub raum ua haujlwm thiabqhov muaj feem cuam tshuam covariates xws li ntshav qab zib thiab kub siab [11]. Kev kuaj mob ntawm CKD los ntawm eGFR<60 mL/min in oldertib neeg tau raug thuam rau qhov kev kwv yees ntau dhau ntawm CKDlub nra rau cov neeg laus vim eGFRfeem ntau poob inversely nrog aging thiab txo ntawmeGFR rau 50-59 mL/min/1.73 uatsis nce kev tuagntawm kev pheej hmoo ntawm cov neeg mobNtau dua lossis sib npaug65 xyoo piv rau cov neeg mobnrog eGFR ntau dua 60 mL / min / 1.73 m2[12,13]. Xwb, ib qho kev tshuaj ntsuam meta-ua los ntawm Coreshua al. sib cav tias txawm tias qhov txo qis hauv eGFR tuaj yeem yogcuam ​​tshuam nrog kev tuag ntau ntxiv thiab kev pheej hmoo ntawm qhov kawgmob raum (ESRD) [14]. Qhov no ua rau muaj kev tsis paub meej txogsiv cov qauv eGFR qhov pib ntawm CKD los kwv yeesqhov tshwm sim rau cov neeg laus. Yog li ntawd, muaj kev xav tauqhov taw qhia rhiab ntau dua lossis cov qauv los ntsuas lub raumkev ua haujlwm hauv cov neeg laus.

Nyem rau ntawm Cistanche tshuaj ntsuab kom txo cov kab mob raum

Tsis ntev los no, Delanaye et al. hu rau lub hnub nyoog-hloov txhais ntawm CKD kom tsis txhob tsim nyogsaib xyuas. Lawv tau hais txog thaum siv eGFRKev txhais rau CKD kuaj mob, CKD yuav tsum tau txhais nroghwm cov txiaj ntsig kho mob lossis teeb meem ntawm lub hnub nyoog tshwj xeebeGFR cov cai. Qhov kev sib cav no tau txais kev txhawb nqalos ntawm kev soj ntsuam tias GFR yuav poob qis nrog kev laustsis muaj ib qho cim qhia ntawm lub raum puas rau cov neeg laus lub raumcov neeg pub dawb, thiab kev pheej hmoo ntawm kev tuag nce ntawmeGFR siab dua ntawm cov neeg hluas dua li cov neeg laus.

Rooj 2: Kev pheej hmoo rau mob raum mob rau cov neeg laus.

Tsuas yog ob peb txoj kev tshawb fawb tau tsom mus rau qhov muaj feem cuam tshuam rau kev txhim khontawm CKD hauv cov neeg laus, txawm tias muaj ntau cov ntaub ntawvhauv cov pejxeem (Table 2) [76, 77]. Raws li tau haisUa ntej, CKD yog ib qho teeb meem ntawm kev lauspej xeem, thiab qhov ua rau uas yuav yog multifactorial. Muaj ntshav qab zib, ntshav siab thiab glomerulonephritis, dyslipidemia, thiab kab mob plawv, nrog rau kev siv tsis tsim nyog ntawm non-steroidal anti-inflammatorytshuaj (NSAIDs) lossis tshuaj ntsuab, tag nrhoua ib feem nyob rau hauv triggering kev puas tsuaj rau lub raum laus nrog txoLub cev muaj zog [78] Tsis tas li ntawd, mob raumraug mob (AKI), uas feem ntau tshwm sim thaum lub sij hawm kawm ntawmCov kab mob hnyav dhau los ua ib qho kev pheej hmoo tseem ceeb rau cov tom ntejkev txhim kho ntawm CKD thiab ESRD [79, 80].

Daim duab: Cistanche tuaj yeem txhim kho koj lub raum ua haujlwm

Ntau thiab ntau tus neeg mob uas muaj mob hnyav tau txais kev cawmdim ntawmtus nqi ntawm AKI. Nyob rau hauv ib tug systematic tshuaj xyuas thiab meta-analysissuav nrog 17 kev tshawb fawb ntawm cov neeg mob AKI,31.3 feem pua ​​​​ntawm cov neeg mob uas muaj sia nyob (Ntau dua lossis sib npaug li 65 xyoo) tsis zoolub raum ua haujlwm piv rau 26 feem pua ​​​​ntawm cov neeg mob hluas[81]. Cov kev tshawb pom no qhia tias cov neeg mob laus tsawg duayuav rov zoo los ntawm mob raum raug mob (AKI),uas yuav muaj kev cuam tshuam qhov txo qis reparative thiab regenerativemuaj peev xwm ntawm lub raum laus.

Daim duab: Cistanche tuaj yeem kho koj lub raum ua haujlwm

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