Tom qab ntau tshaj kaum xyoo ntawm kev siv zog: CAR-T Thaum kawg kho mob qog noj ntshav kom tiav
Mar 28, 2022
Hu rau: Audrey Hu Whatsapp / hp: 0086 13880143964 Email:audrey.hu@wecistanche.com
Ntau tshaj li kaum xyoo tom qab, thaum cov kws kho mob tshaj tawm tias nwsmob qog noj ntshavtau kho, Doug Olson nco qab lub caij nplooj zeeg xyoo 2010 thaum nws koom nrog kev sim tshuaj ntawmCAR-Tcell kho. Nws tseem nco txog nws txoj kev zoo siab thiab kev cia siab rau kev sim kev tshawb fawb. Nws hais tias thaum nws tab tom tshawb fawb txog kev tshawb fawb, zoo li ntau tus kws tshawb fawb hluas, nws npau suav ntawm kev tshawb pom uas yuav muaj kev cuam tshuam rau tib neeg, tab sis nws yeej tsis xav tias nws yuav xaus li no - raws li tus neeg mob koom nrog hauv CAR uas hloov txoj kevmob qog noj ntshavkev kho mob-T kev sim tshuaj.
Qhov sawv ntawmmob qog noj ntshavimmunotherapy tau coj kev cia siab tshiab rau feem coob ntawmmob qog noj ntshavcov neeg mob. Ntawm lawv,CAR-Tcell therapy tau ua pov thawj tias yog ib qho cuab yeej muaj zog tiv thaiv ntshavmob qog noj ntshav. Txawm li cas los xij, me ntsis paub txog lub peev xwm mus sij hawm ntev thiab clonal stability ntawm cov genetic engineeredCAR-Tcell reinfused rau hauvmob qog noj ntshavcov neeg mob.
Kev kho mob qog noj ntshav:CAR-Thlwb &cistanche tshuaj ntsuab
Doug Olson, tus neeg mob tsis muaj hmoo uas mob qog ntshav qog ntshav qog ntshav (CLL), tau kuaj pom hauv xyoo 1996 nrog CLL, tus mob qog nqaij hlav qeeb tab sis kho tsis tau. Tom qab xyoo ntawm kev siv tshuaj khomob, nws tus mob txuas ntxiv mus, thaum lub sijhawm nws pib xav txog kev hloov pob txha pob txha. David Porter, nws tus kws kho mob uas tuaj koom lub sijhawm ntawd, tau hais rau nws tias University of Pennsylvania tab tom yuav pib qhov kev sim tshuaj kho mob.CAR-Tcell kho. Tom qab nyeem cov txheej txheem mus sib hais, nws muaj kev cia siab heev hauv kev lag luam kho mob thiab txiav txim siab koom nrog hauv kev sim tshuaj.
Thaum lub Cuaj Hlis 13, 2010, nws tau los ua tus neeg mob leukemia thib ob hauv ntiaj teb tau txaisCAR-Tcell kho. Cov kws kho mob uas tau tsim txoj kev kho mob rau nws suav nrog Carl June thiab David Porter, tab sis thaum lub sijhawm tsis muaj leej twg paub txog dab tsi.CAR-Tcell kho yog. Cov txiaj ntsig zoo li cas tuaj yeem ua tiav, lawv cia siab tias cov noob caj noob ces CAR-T hlwb tuaj yeem muaj sia nyob hauv lub cev rau ib hlis, thiab txawm tias tsis xav tias yuav kho cov kab mob leukemia.
Ob peb lub lis piam tom qab tau txaisCAR-TKev kho ntawm tes, Doug Olson tsis muajmob qog noj ntshavcov cell hauv nws lub cev. Tom qab kws kho mob hais rau nws cov xov xwm, nws zoo siab heev tias nws tau tshem tawmmob qog noj ntshav, tab sis nws cov kws kho mob tsis paub meej.
Lub sijhawm tau los txog rau 2022, ntau tshaj li kaum xyoo dhau los, lubCAR-Tcov hlwb hauv Doug Olson tseem ua haujlwm ib txwm, thiab nws tseem nyob hauv kev zam txim. Lub sijhawm no, Carl Lub Rau Hli kuj tseem hu ua leej txiv ntawmCAR-Trau nws cov nyiaj pab rauCAR-T. Tam sim no, nws hais tias, tam sim no nws tuaj yeem lees paub tias CAR-T kho Doug Olson thiab qhov ntawdCAR-Ttuaj yeem kho mob leukemia tiag tiag.
Lub Ob Hlis 2, 2022, Carl June et al. luam tawm ib daim ntawv hu ua: Kaum xyoo-ntev leukemia remissions nrog kev mob siab rau ntawm CD4 ntxiv rau CAR T hlwb nyob rau hauv Xwm, qhia txog lub ntiaj teb thawj tus neeg mob tau txaisCAR-TKev kho mob, Bill Ludwig thiab No. Cov txiaj ntsig kev kho mob ntawm ob tus Doug Olson uas tau txaisCAR-Tkev kho mob. Ob leeg tsis tau kuaj pom cov tsos mob ntawm leukemia rau ntau tshaj kaum xyoo tom qab kev kho mob, tab sis hmoov tsis, Bill Ludwig tuag los ntawm mob ntsws tshiab nyob rau lub Ib Hlis 2021.
Txoj kev tshawb no muab pov thawj-ntawm-lub tswv yim rau kev kho mob mus sij hawm ntev thiab kev nyab xeeb ntawm kev koom ua ke rau hauv lub cev ntawmCAR-Tcell kho.
CAR-T cell therapy &cistanche ntxivtuaj yeem kho mob qog noj ntshav tau zoo
CAR-Thlwb yog cov tshuaj tiv thaiv kab mob thiab tiv thaivmob qog noj ntshavLub cev tiv thaiv kab mob T cells los ntawm cov ntshav ntawmmob qog noj ntshavCov neeg mob yog cov tshuaj genetic reprogrammed nyob rau hauv vitro los qhia receptor proteins uas muaj peev xwm paub txog tej antigens ntawmmob qog noj ntshavcov hlwb hauv tus neeg mob, uas yog qhov hu ua chimeric antigen receptor (CAR). Cov noob no tau tsim khoCAR-Tcov hlwb tom qab ntawd nthuav dav siv cov txheej txheem kab lis kev cai ntawm tes thiab rov ua rau cov neeg mob los tuamob qog noj ntshavhlwb.
Txij li xyoo 2017, US FDA tau ua tiav kev pom zoo tsibCAR-TKev kho mob ntawm tes rau kev kho mob leukemia, lymphoma, thiab myeloma. Carl June kwv yees tias kaum tawm txhiab tus neeg thoob ntiaj teb tau txais tam sim noCAR-Tcell kho.
Txawm tiasCAR-Ttau coj kev cia siab raumob qog noj ntshavcov neeg mob, tshwj xeeb tshaj yog cov ntshavmob qog noj ntshavcov neeg mob, kev kho mob kuj muaj ntau yam kev txwv - kim heev, muaj kev pheej hmoo ntawm kev kho mob, thiab kev nyuaj siab. Yog li ntawd, tam sim no,CAR-Ttseem siv los ua qhov chaw kawg tom qab lwm cov kev kho mob tsis zoo.
Tsis tas li ntawd, txawm hais tias qee tus neeg mob tau txais kev tso cai ntev ntev tom qab tau txaisCAR-Tkev kho mob, tsis yog txhua tus neeg mob muaj hmoo heev. Thaum pib, tsuas yog kwv yees li 25 feem pua -35 feem pua ntawm cov kab mob lymphocytic leukemia (CLL) tau txaisCAR-Tkev kho mob. tom qab ua tiav kev zam txim. Txij thaum ntawd los, nrog kev txhim kho thev naus laus zis, qhov kev faib ua feem no tau nce xyoo los ntawm xyoo, tab sis qee cov neeg mob uas tau ua tiav kev zam txim tseem rov qab los. Yog li ntawd, kev tshawb fawb mus sij hawm ntev ntawmmob qog noj ntshavcov neeg mob tau txaisCAR-TKev kho mob tuaj yeem qhia tau tias yam twg ua rau muaj kev tiv thaiv zoo, uas yog qhov tseem ceeb tshwj xeeb rau kev txhim khoCAR-Tkho thiab txhim khomob qog noj ntshavkho tus nqi.
Rau ntau tshaj kaum xyoo, Carl June et al. soj ntsuam kev kho mob ntawm Doug Olson thiab Bill Ludwig, uas tau txais CD19- phiaj xwmCAR-Tkev kho mob hauv 2010, taug qab lawvCAR-Thlwb thiab nrhiav kev txhawj xeeb txog kev nyab xeeb.
Ntau tshaj li kaum xyoo tom qab, lawv tseem tuaj yeem tshawb pom qhov muaj nyob ntawmCAR-Tcov hlwb infused xyoo ntawd, thiab ob tus neeg mob tseem tsis muaj cov tsos mob ntawm leukemia. Nws tsis paub meej tias covCAR-Tcell tua tag nrho cov leukemia hlwb sai tom qab infusion, los yog seb tusCAR-Tcov hlwb thaum ncig hauv lub cev, tuaj yeem tshem tawm cov kab mob leukemia ua ntej lawv mus txog qib kuaj pom.
Qhov tseem ceeb, ob tus neeg mob tau tsim kom muaj CD4 ntxiv rau T cell cov pej xeem uas muaj zog tom qabCAR-Tcell pejxeem (tshaj 95 feem pua). Qhov kev hloov pauv no tau tshwm sim nyob rau hauv lub stabilization ntawm lubCAR-Tcell clonal muaj pes tsawg leeg, dominated los ntawm ib tug me me ntawm clones. Ib leeg-cell tsom xam pom tias cov CD4 ntxiv mus ntevCAR-TCov hlwb tau nthuav tawm cov yam ntxwv cytotoxicity thiab txhawb nqa kev ua haujlwm thiab kev loj hlob. Tsis tas li ntawd, thawj theem teb ntawm ib qho ntawm cov neeg mob tau pom δCAR-TCov pej xeem ntawm tes nrog kev nthuav dav ntawm CD8 ntxivCAR-Thlwb.
Kev txheeb xyuas thiab tus cwj pwm ntawm cov kev npaj txhij txog noCAR-Tcov neeg ntawm tes muab kev nkag siab tshiab rau hauvCAR-Tcell kos npe txuam nrogtshuaj tiv thaiv kab mobteb thiab kev tso cai mus sij hawm ntev, pab pawg tshawb fawb tau hais.
Doug Olson, tus kws saib xyuas kev noj qab haus huv, rov qab mus rau kev kuaj mob tom qab ob peb xyoosCAR-Tkev kho mob, thaum nws pib qoj ib ce thiab khiav ib nrab-marathon. Nws tso dag tias nws tau kho lawmmob qog noj ntshav, tab sis tsis xav kom tuag ntawm lub plawv nres. Txhawm rau pab ntau tus neeg mob qog noj ntshav, nws tau xaiv los tshaj tawm nws zaj dab neeg ntawmmob qog noj ntshavkev kho mob thiab rov zoo, yog li ntawd ntau duamob qog noj ntshavcov neeg mob tuaj yeem pom kev cia siab. Nws hais tias: “Tej zaum yuav kho tsis tau lawvmob qog noj ntshavniaj hnub no, tab sis nws muaj peev xwm hais tias tej yam zoo yuav tshwm sim.
Tshuaj ntsuab cistanche thiab Cistanche tshuaj kho kom zoomob qog noj ntshavkho tus nqi
Lus Cim: Cov tshuaj suav tshuaj suav tshuajcistanche(tseem hu ua"Dragon tshuaj ntsuab"thiab "suab puam ginseng"), loj hlob tsuas yog nyob rau hauv cov suab puam thiab sov so. Raws li ib qho ntawm cuaj yam tsis txawj tuag, Cistanche (cistanche tubulosa / cistanche deserticola / desertliving cistanche / cistanche salsa) cov ntsiab lus nrog nplua nuj cov khoom xyaw xws li echinacoside, acteoside, tag nrho phenylethanoid glycosides, flavonoids. , polysaccharides, thiab lwm yam. Cov khoom xyaw zoo no ua rau cistanche muaj txiaj ntsig zoo tshuaj ntsuab thiab khoom noj khoom haus rau tib neeg lub cev tiv thaiv kab mob, cov kab mob hauv nruab nrog cev, thiab cov hlwb hlwb thiab cov neurons, thiab lwm yam. Cov kev tshawb fawb tshuaj niaj hnub no tau lees paub cov txiaj ntsig ntawm cistanche (cov txiaj ntsig ntawm cistanche): txhim kho kev tiv thaiv kab mob; txhim kho kev sib deev thiab lub raum ua haujlwm;tshuaj tiv thaiv kab mob; tiv thaiv qaug zog; anti-aging; txhim kho kev nco; anti-Parkinson tus kab mob; anti-Alzheimer tus kab mob; antioxidation; yooj yim- cem quav; anti-inflammatory; txhawb cov pob txha loj hlob, ua kom tawv nqaij dawb; tiv thaiv daim siab; lwm.
cistanche deserticola cov txiaj ntsig: tiv thaiv mob qog noj ntshav
