Kev nce qib ntawm cov tshuaj muaj pes tsawg leeg thiab tshuaj muaj txiaj ntsig ntawm Kas fes taum Ⅱ
Nov 01, 2022
3.1 Tiv thaiv cov hlab ntsha ntawm kas fes
3.1.1 Kev Tiv Thaiv Kab Mob Parkinson (PD)
Kev tshawb fawb txog kab mob kis tau pom tias taum kas fes tuaj yeem inhibit qhov tsim ntawm PD. Cov kev tshawb fawb tau pom tias caffeine hauv kas fes taum sib tw inhibits adenosine A1 receptors (A1R) thiab txhim kho kev tso tawm thiab kis ntawm dopamine [47]; kas fes taum extract tseem tuaj yeem txo qhov mob los ntawm kev nce tus naj npawb ntawm bifidobacteria Tib lub sijhawm, nws txo qis cov txheej txheem oncogenic ntawm -synuclein hauv cov hlab ntsha enteric, thiab txo qhov tshwm sim ntawm cov kab mob pathogenic kis los ntawm plab mus rau lub hlwb, yog li txo. Qhov tshwm sim ntawm PD [48]. Hauv kev tshawb fawb ntawm cov neeg mob uas tsis muaj hnub yug PD [49], cov neeg haus kas fes tau qis dua cov qhab nia qis dua li cov neeg haus kas fes, thiab kev haus kas fes tsis zoo cuam tshuam nrog kev mob hnyav ntawm cov neeg mob no. Lee et al. [50] pom tias eicosanol-serotonin hauv kas fes taum tuaj yeem txo cov lus teb neuroinflammatory ntawm MPTP-induced PD, thiab txo qhov tshwm sim ntawm PD hauv cov nas los ntawm inhibiting oxidative stress index thiab activating c-Jun amino-terminal kinase.
3.1.2 Kev Tiv Thaiv Kab Mob Alzheimer (AD)
Kas fes taum tuaj yeem tiv thaiv Alzheimer's kab mob los ntawm ntau yam txheej txheem:
①Caffeine hauv cov taum kas fes tiv thaiv cov neurons los ntawm kev txo cov theem ntawm kev tswj hwm CD45, TLR2, CCL4 thiab lwm yam pro-inflammatory thiab oxidative stress markers hauv AD tsiaj [51];
② Chlorogenic acid thiab caffeic acid nyob rau hauv kas fes taum tuaj yeem kho cov teeb meem cholinergic los ntawm AD los ntawm inhibiting cov dej num ntawm acetylcholinesterase thiab butyrylcholinesterase [52];
(3) Cov kua qaub hauv kas fes taum tuaj yeem cuam tshuam cov glutamate excitotoxicity ua rau AD [53]; Mohamed et al. [54] pom tias ntsuab kas fes taum extract tuaj yeem tswj hwm lub hlwb insulin signaling cascade, thiab tuaj yeem txo AD induced los ntawm insulin tsis kam. Nws muaj cov nyhuv neuroprotective. Qee cov kws tshawb fawb [55] tau kawm txog kev sib raug zoo ntawm kev haus kas fes thiab AD pathological xeev hauv vivo. Cov txiaj ntsig tau qhia tias kev haus kas fes siab tuaj yeem cuam tshuam AD txoj kev pheej hmoo los ntawm kev txo cov kab mob hauv lub hlwb amyloid deposition. Trigonelline hauv kas fes taum tuaj yeem tiv thaiv cov neurons hauv AD nas qauv los ntawm kev puas tsuaj los ntawm inhibiting oxidative kev nyuaj siab, inflammatory teb thiab astrocyte kev ua si [56].
3.1.3 Tiv thaiv kev poob qis ntawm neurocognitive
Kev paub txog kev poob qis tau dhau los ua teeb meem loj zuj zus hauv cov neeg laus nruab nrab thiab cov neeg laus. Kev puas hlwb kev puas hlwb yuav nce mus rau dementia, uas yog ib qho kev pheej hmoo thiab hloov tsis tau. Yog li ntawd, qhov kev daws teeb meem zoo tshaj plaws rau qhov teeb meem no yog los txo qhov tshwm sim ntawm kev paub tsis meej. 5-CQA nyob rau hauv kas fes taum tiv thaiv kev paub tsis meej hauv nas los ntawm kev txo cov nas hippocampal plaque, txo cov neuronal puas, thiab txo Abeta deposition [57]. Cov kws tshawb fawb Dutch [58] tau tshawb xyuas qhov kev paub ntawm cov txiv neej laus hauv 10 xyoo thiab pom tias kev txawj ntse ntawm cov txiv neej uas haus kas fes txo qis los ntawm 1.2 feem pua, thiab kev txawj ntse ntawm cov txiv neej uas tsis haus kas fes txo los ntawm 1.4%.
3.1.4 Kev tiv thaiv kab mob vwm
Caffeic acid nyob rau hauv kas fes taum tuaj yeem txo qhov apoptosis ntawm hippocampal thiab prefrontal cortex hlwb hauv cov nas mob vwm [59]
, txo cov oxidative kev ntxhov siab cov khoom tsim los ntawm cov nas xeev epilepticus [60], thiab muaj cov nyhuv neuroprotective rau cov nas mob vwm. Ntxiv rau cov teebmeem neuroprotective uas tau teev tseg saum toj no, Kahweol hauv kas fes taum tuaj yeem tswj hwm cov haujlwm neuroprotective ntawm antioxidant enzymes hauv tib neeg neuroblastoma hlwb los ntawm p38 / Nrf2 signaling pathway [61], thiab tuaj yeem tswj cov hauv paus dorsal ganglia ntawm nas. Cov nyhuv analgesic [62]
3.2 Kev tiv thaiv kab mob ntshav qab zib hom 2
Mob ntshav qab zib yog ib yam kab mob cuam tshuam los ntawm ob qho tib si caj ces thiab ib puag ncig. Nrog rau txoj kev loj hlob ntawm haiv neeg, qhov xwm txheej tau nce zuj zus txhua xyoo. Mob ntshav qab zib thiab nws cov teeb meem tau maj mam dhau los ua plaub tus kab mob loj tshaj plaws hauv ntiaj teb. Txo cov ntshav qab zib thiab txo qis kev pheej hmoo ntawm ntshav qab zib yog txoj hauv kev zoo tshaj plaws los tiv thaiv cov kab mob no. Txoj kev. Hom 2 mob ntshav qab zib mellitus yog hom mob ntshav qab zib hom 2 thiab yog tshwm sim los ntawm kev sib xyaw ua ke ntawm insulin tsis kam thiab tsis txaus cov tshuaj insulin. Kev tshawb fawb txog kab mob kis tau pom tias kev haus kas fes nruab nrab tuaj yeem txo qhov kev pheej hmoo ntawm ntshav qab zib hom 2 [63].
Ib txoj kev tshawb nrhiav pom tias kas fes decaffeinated muaj peev xwm txo tau txoj kev pheej hmoo ntawm hom 2 mob ntshav qab zib [64]
. Polyphenols hauv kas fes taum muaj kev tiv thaiv kab mob ntshav qab zib rau cov neeg mob ntshav qab zib hom 2 los ntawm kev ua kom cov piam thaj metabolism sai, txo qis insulin tsis kam thiab qib glycated hemoglobin [65]. Chlorogenic acid hauv kas fes taum tuaj yeem tiv thaiv hom 2 mob ntshav qab zib los ntawm kev tswj cov piam thaj thiab lipid metabolism hauv cov rog, siab-qab zib thiab streptozotocin-induced hom 2 mob ntshav qab zib nas [66]. Trigonelline nyob rau hauv kas fes taum tuaj yeem tiv thaiv hom 2 mob ntshav qab zib los ntawm kev txo cov ntshav qab zib thiab cov ntshav lipid, txhim kho cov tshuaj insulin rhiab heev, thiab kev tswj hwm cov tshuaj tiv thaiv antioxidant [67]. Kahweol nyob rau hauv kas fes taum accelerates qabzib-stimulated insulin secretion thiab tsub kom cov piam thaj uptake nyob rau hauv tib neeg skeletal hlwb, yog li txo qhov kev pheej hmoo ntawm hom 2 mob ntshav qab zib nyob rau hauv tib neeg [68].
3.3 Anti-mob cancer
3.3.1 mob qog noj ntshav
Txawm hais tias txoj hauv kev zoo tshaj plaws rau kev mob qog noj ntshav hauv plab yog kev phais thiab kev kho mob ntxiv, kev tuag ntawm cov qog nqaij hlav hauv plab tseem siab, yog li chemoprevention yog ib qho txiaj ntsig zoo ntawm kev tiv thaiv kab mob qog noj ntshav yuav tsum tau them nyiaj rau. kas fes
Kahweol hauv taum tau pom tias muaj kev tiv thaiv kabmob kheesxaws tseem ceeb, tiv thaiv kev mob qog noj ntshav hauv plab los ntawm kev txhawb nqa qhov kev qhia ntawm apoptotic factor Caspase-3, txo cov kev qhia ntawm cov tshuaj tiv thaiv apoptotic (Bcl-2, phosphorylated Akt) , thiab inhibiting qhov kev qhia ntawm HSP70 protein qog loj hlob [69]. Caffeic acid nyob rau hauv kas fes taum tuaj yeem cuam tshuam kev ua haujlwm ntawm ob qho protein kinases (MEK1 thiab TOPK) tau qhib thaum lub sijhawm mitosis hauv cov qog nqaij hlav hauv plab, yog li inhibiting phosphorylation ntawm proline-directed serine / threonine kinases (ERKs), cov ntaub ntawv hloov pauv (AP{{8}) }, NF-IIB) ua kom muaj zog, yog li inhibiting cov qog hloov pauv ntawm jb6p ntxiv rau cov hlwb raug ntxias los ntawm oncogenes (TPA, EGF thiab HRAS) [70]. Bessler et al. [71] tau kawm txog cov txheej txheem uas caffeine sib npaug peripheral ntshav mononuclear hlwb (PBMC) nrog tib neeg cov qog nqaij hlav qog noj ntshav (HT-29) thiab tib neeg cov colon adenocarcinoma cells (RKO). Kev tso tawm ntawm inflammatory cytokines txhim kho lub xeev inflammatory, yog li inhibiting kev mob qog nqaij hlav hauv plab.
High-Quality Cistanche Coffee: Yog xav paub ntxiv nias ntawm no
3.3.2 mob qog noj ntshav
Zhao [72]
et al conducted a meta-analysis between coffee intake and the incidence of liver cancer, and found that coffee intake was inversely related to the risk of liver cancer, and high doses of coffee were more effective. Kahweol, Cafestol, and diterpenoids in coffee beans can act as blockers to block a variety of enzymes involved in hepatocarcinogenesis; they can also alter xenotoxicity by inducing glutathione-S-transferase and inhibiting N-acetyltransferase Metabolism to fight liver cancer [73]. Wiltberger et al. [74] drinking coffee before and after liver transplantation in patients with liver cancer and found that patients with postoperative coffee intake (>3 khob ib hnub) muaj lub sij hawm ciaj sia ntev dua li lwm tus neeg mob. lub cev-mediated daim siab mob hlwb. Caffeine thiab chlorogenic acid nyob rau hauv kas fes taum tuaj yeem ua rau lub cell faib theem II
Detoxification enzymes thiab antioxidant enzymes tuaj yeem cuam tshuam qhov kev qhia lossis txo cov kev ua haujlwm ntawm theem I activating enzymes, yog li tiv thaiv mob qog noj ntshav [75].
3.3.3 Prostate cancer
Kas fes taum tuaj yeem inhibit qhov kev loj hlob ntawm prostate cancer. Cov txheej txheem ntawm 6 yam tshuaj nquag hauv kas fes taum inhibiting prostate cancer tau kawm. Los ntawm kev ntsuam xyuas apoptosis-hais txog cov proteins, androgen receptors thiab chemokines, nws tau pom tias Kahweol thiab Cafestol tuaj yeem cuam tshuam kev loj hlob thiab kev tsiv teb tsaws ntawm cov qog nqaij hlav prostate [76]. Kolberg et al. [77] tau kawm txog cov txiaj ntsig ntawm kas fes extract ntawm kev tswj hwm cov noob hauv tib neeg PC3 (prostate cancer hlwb) thiab liab qab nas PC3 xenografts, thiab pom tias kas fes extract inhibited cov haujlwm ntawm NF-κB hauv PC3 hlwb hauv vitro thiab hauv xenografts. li no inhibiting mob qog noj ntshav prostate. Montenegro et al [78] tau ua microwave-pab extraction ntawm plaub hom kas fes taum tom qab roasting rau txawv degrees, thiab pom tias inhibitory nyhuv ntawm kas fes extract rau tib neeg prostate cancer (DU145) cell kab muaj zog tshaj li PC3 cell prostate cancer. kab ntawm tes, thiab nws muaj zog inhibitory nyhuv ntawm mitotic S thiab S thiab P. G2/M cell voj voog raug ntau dua thiab tuaj yeem tiv thaiv qog noj ntshav prostate.
3.3.4 Mob ntsws cancer
Cov kev tshawb fawb tau pom [79] tias cov tshuaj chlorogenic acid nyob rau hauv kas fes taum muaj qhov cuam tshuam tseem ceeb rau tib neeg lub ntsws cancer (A549) cell kab, thiab cov txheej txheem yog tias cov tib neeg rov ua dua tshiab annexin (Annexin A2) yog chlorogenic acid hauv A549 cell kab. . Covalently khi rau lub hom phiaj, chlorogenic acid inhibits kev khi ntawm Annexin A2 rau p50 subunit ntawm NFκB protein, yog li inhibiting kev qhia ntawm anti-apoptotic genes (cIAP1, cIAP2) downstream ntawm NF-IIB signaling txoj hauv thiab tawm ntawm A549 hlwb. , yog li inhibiting A549 Cell proliferation thiab migration. Tsis tas li ntawd, kas fes kuj tseem tuaj yeem ua tus inhibitor ntawm oxidative stress transcription factor Nrf2, thaiv Nrf2-kev ua haujlwm ntawm proteasome, yog li txhawb nqa apoptosis ntawm pancreatic cancer hlwb [80]; extracts ntawm Robusta kas fes tuaj yeem ua rau lub sijhawm S ntawm cov qog nqaij hlav cancer mis nce, tus naj npawb ntawm G2 / M txo, uas cuam tshuam rau mitochondrial morphology thiab ua rau apoptosis [81];
3.4 Anti-inflammatory
Inflammatory teb yog ib txoj kev tiv thaiv kab mob lom los ntawm cov tshuaj endogenous nyob rau hauv lub cev, thiab nws lub luag hauj lwm tseem ceeb yog tshem tawm cov teeb meem stimuli. Cov kev tshawb fawb tau pom tias caffeine hauv taum kas fes tuaj yeem ua lub luag haujlwm hauv cov kab mob neurodegenerative
Overregulation ntawm A2A-type adenosine receptors tswj microglial cov lus teb thiab inhibits neuroinflammation [82], thiab tuaj yeem inhibit lipopolysaccharide-induced nas monocytes los ntawm activating phosphorylation ntawm NF-κB protein thiab mitogen-activated protein kinase. Inflammatory responses in macrophage leukemia cells (RAW264.7) [83]. Chlorogenic acid nyob rau hauv kas fes taum thiab nws cov metabolites caffeic acid thiab ferulic acid muaj inhibitory cuam tshuam rau cov inflammatory teb ntawm tib neeg microvascular endothelial hlwb, los ntawm kev txo cov secretion ntawm interleukin 6 (IL-6), interleukin 8 (IL{{12}). }), cov ntaub so ntswg plasminogen activator (T-PA),
Endothelial cell-type plasminogen activator inhibitor (PAI-1) thiab intercellular adhesion molecule (ICAM-1) [84]. Zhao Haiping et al[85] siv homocysteine (Hcy) los ntxias cov ntshav peripheral leukocytes ntawm 8-cov txiv neej hnub nyoog ib lim piam, kho nrog caffeic acid, thiab kuaj pom qhov qhia ntawm myeloperoxidase MPO thiab p-ERK1/2 hauv leukocytes. . , xaus lus tias caffeic acid tuaj yeem ua rau muaj kev tso tawm ntawm cov kab mob inflammatory MCP-1 thiab MPO nyob rau hauv peripheral ntshav leukocytes ntawm cov nas los ntawm inhibiting qhov kev qhia ntawm p-ERK1/2, yog li cuam tshuam nrog inflammatory teb. Tan Yinfeng et al. [86] pom tias kas fes hauv av extract tuaj yeem txo pob ntseg pob ntseg los ntawm xylene hauv cov nas, thiab tib lub sijhawm inhibit qhov nce ntawm capillary permeability tshwm sim los ntawm acetic acid hauv cov nas, thiab muaj kev tiv thaiv kab mob rau cov nas. .
3.5 Antioxidant
Nyob rau hauv xyoo tas los no, kev siv cov tshuaj antioxidants ntuj los tawm tsam cov kab mob oxidative kev ntxhov siab hauv lub cev tau txais kev saib xyuas ntau. Kas fes, ib qho dej haus uas nquag siv, muaj ntau yam kev noj haus antioxidants. Cov kev tshawb fawb tau pom tias ntsuab kas fes extract tuaj yeem tshem tawm DPPH dawb radicals thiab ABTS dawb radicals [87]. Cov ntsiab lus ntawm cov tshuaj tsis hloov pauv xws li pyrrole, pyrazine, thiab furan hauv cov taum kas fes tau zoo sib xws nrog lub peev xwm antioxidant ntawm Ferric ion txo lub zog antioxidant (FRAP) [88]. Kalthoff et al. [89] pom tias kas fes taum extract tuaj yeem cuam tshuam cov lus teb oxidative kev ntxhov siab vim yog haus luam yeeb carcinogen benzpyridine los ntawm kev ua kom cov noob tseem ceeb UGT1A koom nrog hauv tib neeg metabolic voj voog. Chen et al. [90] kuaj pom cov nyhuv ntawm 5-CQA hauv kas fes taum ntawm cov pa oxygen reactive (ROS) thiab glutathione (r-glutamyl custeinal plus glycine, r-glutamyl custeinal plus glycine) hauv hepatocytes induced los ntawm tert-butyl hydroperoxide. GSH), thiab pom tias 5-CQA tuaj yeem ua tus Nrf2 activator los tiv thaiv ROS thiab GSH, thiab tuaj yeem cuam tshuam oxidative stress-mediated siab puas tsuaj. Cov kev tshawb fawb tau pom tias muaj peev xwm antioxidant ntawm Arabica kas fes taum nce nrog qib ntawm roasting [91].
3.6 Kev tiv thaiv daim siab
Muaj ntau cov pov thawj uas taum kas fes tuaj yeem tiv thaiv kab mob siab los ntawm ntau yam ua rau. Kev tshawb fawb txog kab mob kis tau pom [92] tias kev haus kas fes tsis zoo cuam tshuam nrog kev mob siab rau kev tuag. Kev haus ntau tshaj 2 khob kas fes ib hnub tuaj yeem txo cov kab mob siab rau kev tuag. Caffeine hauv kas fes taum tuaj yeem tiv thaiv nas daim siab fibrosis vim los ntawm diethylnitrosamine (DEN) thiab carbon tetrachloride (CCl4) los ntawm cov teebmeem antioxidant thiab inhibition ntawm fibrotic cytokines TGF-beta thiab PDGF-beta [93]. Kas fes taum extract tuaj yeem tiv thaiv cov kab mob tsis muaj dej cawv fatty siab, thiab nws cov txheej txheem zoo ib yam li kas fes
Nws muaj feem xyuam rau kev txhim kho qhov kev qhia ntawm mitochondrial stress proteins thiab inducing redox xeev regulators [94]
. Lee et al. [95] pom tias cov diterpenoids Kahweol thiab Cafestol nyob rau hauv kas fes taum inhibit CCl4-induced hepatotoxicity los ntawm thaiv cytochrome isoenzyme p450 (CYP2E1)-mediated biological activation thiab scavenging dawb radicals.
3.7 Kev tiv thaiv kab mob plawv
Meta-analysis qhia tau hais tias kev haus kas fes nruab nrab (2-4 khob ib hnub) tuaj yeem txo qis kev tuag ntawm cov hlab plawv [96]. Chlorogenic acid nyob rau hauv kas fes taum inhibits zus tau tej cov vascular reactive oxygen hom, txo oxidative kev nyuaj siab, thiab tsub kom nitric oxide bioavailability thiab lwm yam mechanisms txo cov ntshav siab thiab vascular hypertrophy nyob rau hauv spontaneously hypertensive nas [97]. Qee cov kws tshawb fawb tau taw qhia tias kev haus kas fes nruab nrab tuaj yeem txhim kho cov kab mob plawv, arrhythmia thiab plawv tsis ua haujlwm [98]. Hauv kev tshawb fawb ntawm 1227 cov neeg mob uas muaj lub plawv tsis ua haujlwm ntev, kev haus kas fes ntau dua tau pom tias muaj kev cuam tshuam cuam tshuam nrog cov xwm txheej atrial fibrillation [99].
3.6 Kev tiv thaiv daim siab
Muaj ntau cov pov thawj uas taum kas fes tuaj yeem tiv thaiv kab mob siab los ntawm ntau yam ua rau. Kev tshawb fawb txog kab mob kis tau pom [92] tias kev haus kas fes tsis zoo cuam tshuam nrog kev mob siab rau kev tuag. Kev haus ntau tshaj 2 khob kas fes ib hnub tuaj yeem txo cov kab mob siab rau kev tuag.
Caffeine hauv kas fes taum tuaj yeem tiv thaiv nas daim siab fibrosis vim los ntawm diethylnitrosamine (DEN) thiab carbon tetrachloride (CCl4) los ntawm cov teebmeem antioxidant thiab inhibition ntawm fibrotic cytokines TGF-beta thiab PDGF-beta [93]. Kas fes taum extract tuaj yeem cuam tshuam cov kab mob tsis muaj dej cawv fatty siab, thiab nws cov txheej txheem cuam tshuam nrog kas fes txhim kho mitochondrial stress proteins thiab inducing kev qhia ntawm redox xeev regulators [94]. Lee et al. [95] pom tias cov diterpenoids Kahweol thiab Cafestol hauv kas fes taum inhibit CCl4-induced hepatotoxicity los ntawm thaiv cytochrome isoenzyme p450 (CYP2E1)-mediated biological activation thiab scavenging dawb radicals.
3.7 Kev tiv thaiv kab mob plawv
Meta-analysis qhia tau hais tias kev haus kas fes nruab nrab (2-4 khob ib hnub) tuaj yeem txo qis kev tuag ntawm cov hlab plawv [96]. Chlorogenic acid nyob rau hauv kas fes taum inhibits zus tau tej cov vascular reactive oxygen hom, txo oxidative kev nyuaj siab, thiab tsub kom nitric oxide bioavailability thiab lwm yam mechanisms txo cov ntshav siab thiab vascular hypertrophy nyob rau hauv spontaneously hypertensive nas [97]. Qee cov kws tshawb fawb tau taw qhia tias kev haus kas fes nruab nrab tuaj yeem txhim kho cov kab mob plawv, arrhythmia thiab plawv tsis ua haujlwm [98]. Hauv kev tshawb fawb ntawm 1227 cov neeg mob uas muaj lub plawv tsis ua haujlwm ntev, kev haus kas fes ntau dua tau pom tias muaj kev cuam tshuam cuam tshuam nrog cov xwm txheej atrial fibrillation [99].
3.8 Antibacterial
Cov tshuaj tiv thaiv kab mob ib txwm muaj kev ua haujlwm siab, muaj kev phiv loj, thiab lub sijhawm luv. Hauv cov ntsiab lus no, cov tshuaj ntuj nrog cov tshuaj tua kab mob tau txais kev saib xyuas zoo. Cov kev tshawb fawb tau pom tias taum kas fes ntsuab muaj kev tiv thaiv kev tiv thaiv Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum thiab Actinomyces [100]. Caffeine thiab chlorogenic acid nyob rau hauv kas fes taum muaj cov tshuaj tua kab mob ntawm Serratia marcescens, Enterobacter cloacae thiab Salmonella [101]. Caffeic acid thiab protocatechuic acid nyob rau hauv kas fes taum inhibit Legionella pneumophila
Cov nyhuv [102].
3.9 Tiv thaiv cov pob txha
Trigonelline hauv kas fes taum tuaj yeem txo cov pob txha pob txha hauv cov nas mob ntshav qab zib streptozotocin thiab ua kom cov pob txha ceev hauv nicotinamide / streptozotocin-kho nas [103]. Kahweol hauv kas fes taum tuaj yeem tiv thaiv kev tsim ntawm nas osteoclasts los ntawm inhibiting phosphorylation ntawm extracellular teeb liab tswj kinase thiab Akt qhib los ntawm receptor activator ntawm nuclear factor kappa-B ligand (RANKL) [104]]. Fukuma et al. [105] pom tias Cafestol thiab Kahweol tsis tsuas yog inhibited tsim ntawm osteoclasts, tab sis kuj txhawb kev sib txawv ntawm osteoblasts.
3.10 Txo cov ntshav lipids
Cov kev tshawb fawb tau pom tias muaj kev sib raug zoo ntawm koob tshuaj ntawm kev haus kas fes ntau dua thiab qis dua lub cev rog feem pua, qhia tias kas fes cuam tshuam nrog kev txo qis lipid [106]. Ntsuab kas fes taum extract tuaj yeem txo lub cev qhov hnyav, ntshav tag nrho cov roj cholesterol thiab triglycerides hauv cov khoom noj muaj roj ntau vim cov nas [107]. Polyphenols hauv kas fes taum los ntawm downregulating (SREBP) -1c antibody, acetyl-CoA carboxylase-1 thiab -2, stearoyl-CoA desaturase-1 thiab pyruvate dehydrogenase kinase{11} } mRNA qib, txhawb lub cev lub zog metabolism, txo cov rog ntau lawm, yog li inhibiting rog tsub zuj zuj [108].
3. 11 Lwm tus
Kas fes taum kuj tiv thaiv kev ua me nyuam, txhawb cov metabolism thiab kev ua estrogen. Al-Megrin et al [109] pom tias Arabica kas fes taum extract tuaj yeem pab kho cov qog ntshav tsis ua haujlwm vim yog mob ntshav qab zib hom 2. Ho et al [110] qhia tias kas fes decaffeinated tau
Nws tswj cov noob muaj feem xyuam rau lub zog metabolism hauv lub hlwb, yog li txhawb zog metabolism hauv lub hlwb.
4 Kev xaus
Kas fes yog ib qho ntawm cov dej haus ntau tshaj plaws hauv ntiaj teb. Ua ntej xyoo pua 20th, kas fes feem ntau nrov hauv qee lub tebchaws xws li South America thiab Europe. Nrog rau kev loj hlob ntawm tib neeg thiab kev nthuav dav ntawm kas fes kab lis kev cai, kas fes tau maj mam nrov thiab nrov. Kev tshawb fawb txog cov tshuaj muaj pes tsawg leeg thiab cov tshuaj pharmacological ntawm kas fes tau ua tiav tseem ceeb, tab sis tseem muaj cov chaw uas yuav tsum tau tshawb xyuas sai, xws li cov tshuaj lom neeg cov tshuaj tiv thaiv kab mob hauv cov txheej txheem roasting ntawm cov taum kas fes tseem tsis tau nkag siab tag nrho, qhov zoo. Kev ntsuas ntsuas thiab kev tswj xyuas zoo ntawm cov taum kas fes tsis zoo tag nrho, qhov sib xyaw ntawm cov kev tsis zoo ntawm kas fes rau kev haus dej mus ntev ntawm cov neeg laus thiab cov menyuam yaus, kas fes dependence Cov txheej txheem tsim thiab theem ntawm kev sib deev tseem tsis meej. Yog li ntawd, nws muaj peev xwm ua qauv thiab qhia kev siv taum kas fes los ntawm kev kawm ntxiv txog cov tshuaj muaj pes tsawg leeg, cov tshuaj pharmacological thiab kev sib raug zoo ntawm cov taum kas fes, thiab muab lub hauv paus rau kev txhim kho zoo ntawm kev lag luam kas fes.
Kev them nyiaj yug: wallence.suen@wecistanche.com 0015292862950
