Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Kev Nyab Xeeb thiab Kev Ua Tau Zoo Ntawm Cov Ntawv Thov Ntawm MYOWNN ™ , Ib qho Kev Loj Hlob Factor Concentrate (AGFC) Serum, hauv Anti-Aging
Jul 07, 2023
Abstract
Keeb kwm
Kev loj hlob ntawm cov platelets tau tshwm sim raws li kev kho mob hloov kho nrog lub peev xwm los txhawb kev loj hlob ntawm tes hauv daim tawv nqaij, uas ua rau rov qab thiab thim rov qab cov txheej txheem kev laus. Platelet-nplua nuj ntshav plasma (PRP) tso cai rau kev tso tawm ntau dua ntawm kev loj hlob thiab cov proteins uas muaj roj ntsha, uas ua rau muaj kev cuam tshuam ntawm stimulation ntawm neoangiogenesis thiab collagen ntau lawm. PRP yog siv los tiv thaiv kev laus thiab lub ntsej muag ntawm daim tawv nqaij rejuvenation nyob rau hauv daim ntawv ntawm dermal txhaj thiab tshuaj pleev ib ce thaum lub sij hawm micro-koob. Txoj kev tshawb no tau ua los ntsuas kev nyab xeeb thiab kev ua tau zoo ntawm cov tshuaj pleev ntsej muag, MYOWNN ™ (Wockhardt Ltd., Mumbai, India). MYOWNN ™ yog ib qho autologous loj hlob zoo mloog zoo uas tau ua rau lub ntsej muag pleev xim.
Glycoside ntawm cistanche tuaj yeem ua rau muaj kev ua haujlwm ntawm SOD hauv plawv thiab daim siab cov ntaub so ntswg, thiab txo cov ntsiab lus ntawm lipofuscin thiab MDA hauv txhua cov ntaub so ntswg, tshem tawm ntau yam reactive oxygen radicals (OH-, H₂O₂, thiab lwm yam) thiab tiv thaiv DNA puas. los ntawm OH-radicals. Cistanche phenylethanoid glycosides muaj peev xwm tshem tawm cov dawb radicals, muaj peev xwm txo tau ntau dua li cov vitamin C, txhim kho cov haujlwm ntawm SOD hauv cov phev ncua, txo cov ntsiab lus ntawm MDA, thiab muaj qee yam kev tiv thaiv ntawm cov phev ua haujlwm. Cistanche polysaccharides tuaj yeem txhim kho kev ua haujlwm ntawm SOD thiab GSH-Px hauv erythrocytes thiab ntsws cov ntaub so ntswg ntawm cov nas senescent sim los ntawm D-galactose, nrog rau txo cov ntsiab lus ntawm MDA thiab collagen hauv lub ntsws thiab ntshav, thiab nce cov ntsiab lus ntawm elastin, muaj Cov nyhuv scavenging zoo ntawm DPPH, ncua lub sijhawm ntawm hypoxia hauv cov nas senescent, txhim kho cov haujlwm ntawm SOD hauv cov ntshav, thiab ncua lub physiological degeneration ntawm lub ntsws hauv kev sim cov nas nrog cellular morphological degeneration, kev sim tau pom tias Cistanche muaj peev xwm antioxidant zoo. thiab muaj peev xwm los ua ib qho tshuaj tiv thaiv thiab kho cov kab mob ntawm daim tawv nqaij laus. Nyob rau tib lub sijhawm, echinacoside hauv Cistanche muaj lub peev xwm tseem ceeb txhawm rau txhawm rau DPPH dawb radicals thiab muaj peev xwm tshem tawm cov pa oxygen reactive thiab tiv thaiv dawb radical-induced collagen degradation, thiab kuj muaj kev kho zoo ntawm thymine dawb radical anion puas.
Nyem rau ntawm Cistanche Tubulosa Ntxiv
【Yog xav paub ntxiv:george.deng@wecistanche.com / WhatApp:86 13632399501 】
Cov txheej txheem
Cov txiv neej thiab poj niam cov kev kawm nyob rau hauv pawg hnub nyoog ntawm 30 thiab 55 xyoo (ob leeg suav nrog) nrog Fitzpatrick tawv nqaij hom III-V uas tsis tau noj tshuaj kho qhov ncauj lossis tshuaj pleev ib ce tsawg kawg plaub lub lis piam ua ntej thiab cov platelet-nplua nuj plasma (PRP) raws li lub ntsej muag kev kho mob (txhaj tshuaj) tsawg kawg yog rau lub hlis ua ntej kev kawm nkag tau suav nrog. MYOWNN ™ cov tshuaj pleev ib ce rau ntawm lub ntsej muag ib zaug ib hnub thaum hmo ntuj, kwv yees li 30 feeb ua ntej pw tsaug zog zoo dua, rau tag nrho ntev ntawm tsib lub hlis. Rau qhov tsis xws luag, xws li pob, pores, wrinkles, kev ntxhib los mos, noo noo, thiab pigmentation, tau soj ntsuam ib ntus nrog Visage-LS (dermaindia®, Tamil Nadu, Is Nrias teb), lub ntsej muag tsom xam uas muab cov xwm txheej ntawm rau qhov tsis zoo no thiab yog cov cuab yeej siv tshuaj ntsuam xyuas cov tawv nqaij zoo ua ke nrog kev tua, tshuaj xyuas, thiab kev ua haujlwm, nrog rau kev tsom xam cov ntsiab lus, tau ua los ntawm cov neeg kawm thiab cov kws kho mob siv cov ntsuas sib txawv thoob ntiaj teb lees paub xws li tus kws kho mob lub ntiaj teb kev txhim kho kev zoo nkauj (PGAIS), kev txhim kho kev zoo nkauj thoob ntiaj teb. scale (SGAIS), qhov qhab nia txaus siab (SSS), thiab qhov ntsuas qhov hnyav (WSRS). Rau kev tsom xam, ib qho qauv sib xyaw rau kev ntsuas rov qab tau siv. Tus qauv tau hloov pauv los ntawm cov hauv paus ntsiab lus raws li qhov sib txawv ntawm kev mus ntsib raws li qhov tseem ceeb thiab cov txiaj ntsig kev ntsuam xyuas hauv paus raws li covariate. Tag nrho cov ntsiab lus tseem ceeb thiab theem nrab kev ua tau zoo tau raug tshuaj xyuas siv Modified Intent-to-Treat (mITT) cov pej xeem.
Cov txiaj ntsig
Kev txhim kho nyob rau hauv qhov nruab nrab ntawm rau qhov kev tiv thaiv kev laus tau pom thaum ntxov li peb lub hlis thaum qhov kev txhim kho tseem ceeb tau pom los ntawm qhov kawg ntawm tsib lub hlis ntawm daim ntawv thov. Ib qho kev txhim kho tseem ceeb hauv cov wrinkles tau pom los ntawm qhov kawg ntawm peb lub hlis ntawm daim ntawv thov nws tus kheej. Tsis muaj cov khoom muaj feem cuam tshuam txog cov xwm txheej phem tshaj tawm.
Cov lus xaus
Tsib lub hlis ntawm daim ntawv thov ntawm MYOWNN ™ cov ntshav tau pom qhov kev txhim kho tseem ceeb hauv qhov nruab nrab ntawm rau qhov kev tiv thaiv kev laus thiab lub ntsej muag rov ua kom rov zoo dua nrog p-tus nqi ntawm 0.0150 (<5% level of significance (i.e. 0.05) and was also well-tolerated.
Pawg: Dermatology
Ntsiab lus: wrinkle qhov hnyav ntsuas ntsuas, qhov loj hlob zoo, wrinkles, antiaging, rejuvenation
Taw qhia
Cov tawv nqaij ua tiav ntau yam haujlwm, suav nrog kev tiv thaiv cov dej percutaneous, kev saib xyuas qhov kub thiab txias, kev nkag siab ntawm lub cev, thiab kev tiv thaiv kab mob [1]. Tsis tas li ntawd, kev noj qab haus huv ntawm daim tawv nqaij thiab cov tsos mob ua lub luag haujlwm tseem ceeb hauv kev hwm tus kheej thiab kev sib raug zoo [2].
Ib puag ncig yam tseem ceeb, xws li raug tshav ntuj, haus luam yeeb, thiab huab cua muaj kuab paug, nrog rau cov khoom siv hauv nruab nrog xws li kev ua kom lub cev muaj zog thiab khoom noj khoom haus tsis zoo, ua rau cov tawv nqaij laus, ua rau cov tawv nqaij atrophy maj mam, nplua thiab ntxhib wrinkles, thiab tawv nqaij qhuav nrog poob ntawm laxity. , elasticity, thiab ntxhib kev ntxhib los mos. Ob qho tib si extrinsic thiab intrinsic yam ua rau cov tawv nqaij laus nrog photoaging, piv txwv li ntev raug rau UV hluav taws xob yog qhov tseem ceeb ntawm extrinsic tawv nqaij laus [3-4].
Kev laus txo qis basal txheej cell proliferation thiab ua rau thinning ntawm lub epidermis, ua rau txo qis ntawm qhov chaw sib cuag ntawm lub epidermis thiab dermis, uas txo cov khoom noj khoom haus ntawm cov epidermis. Kev noj zaub mov tsis txaus ua rau lub peev xwm ntawm cov hlwb ntawm cov txheej txheem basal kom proliferate [5-6]. Tsis tas li ntawd, lub dermis ntawm daim duab tiv thaiv hnub nyoog ntawm daim tawv nqaij qhia tsis tau tsuas yog tsawg mast hlwb thiab fibroblasts tshaj li yees duab-tiv thaiv cov tawv nqaij tab sis kuj rarefied collagen fibers thiab elastic fibers [7].
Photoaging suav txog li ntawm 80 feem pua ntawm lub ntsej muag laus [8], tab sis nws kuj ua rau cov epidermis thickening, uas yog qhov sib txawv ntawm cov khoom siv hauv lub cev, xws li thinning ntawm cov epidermis ua rau cov tawv nqaij laus [9].
PRP tau txais kev saib xyuas zoo nyob rau xyoo tas los no hauv cov xwm txheej sib txawv xws li kev tsim cov ntaub so ntswg, kho qhov txhab, kho caws pliav, thiab alopecia, nrog rau cov tawv nqaij rejuvenation [10]. Cov teebmeem tshwm sim los ntawm kev siv PRP yog vim muaj cov yam ntxwv loj hlob nyob rau hauv cov platelets, uas tau tso tawm ntawm kev ua kom muaj zog.
Kev loj hlob yam yog muab los ntawm ib qho kev kawm tag nrho cov ntshav. Cov ntshav yog spun rau hauv lub centrifuge, uas tso cai rau cov ntshav liab tshem tawm [11]. Feem ntau cov tshuab yuav tsum muaj ob theem centrifuging los tsim cov khoom kawg. Thaum cov qe ntshav liab raug tshem tawm, cov ntshav plasma ntxiv yog rov centrifuged, uas tso cai rau cov txheej txheem platelet nplua nuj raug rho tawm, uas tom qab ntawd qhib nrog thrombin lossis calcium chloride. Cov kauj ruam no ua rau cov platelets pib tso cov kev loj hlob zoo li vascular endothelial kev loj hlob zoo (VEGF) thiab fibroblast kev loj hlob yam khoom -2 (FGF-2), uas txhim kho revascularization thiab angiogenesis, thaum collagen synthesis ntseeg tau tias yog stimulated los ntawm kev hloov pauv kev loj hlob-beta (TGF- ). Lwm yam kev loj hlob zoo li epidermal growth factor (EGF), insulin zoo li kev loj hlob zoo (IGF), thiab platelet-derived growth factor (PDGF) kuj raug tso tawm.
PRP kev kho mob tau ua tiav qhov kev kho mob sai dua hauv cov luav [12] piv rau cov ntsev ib txwm siv Wockhardt's Growth Factor Concentrate (Wockhardt Ltd., Mumbai, India) hauv excised tus qauv hauv cov kab mob ntshav qab zib thiab cov nas tsis muaj mob ntshav qab zib, uas ua rau pom kev zoo dua thiab kev cog lus ntawm lub qhov txhab. [13]. Kev txhim kho tseem ceeb tau pom nyob rau hauv cov ntaub so ntswg kho hauv qhov ncauj phais los ntawm autologous PRP daim ntawv thov [14]. Lub peev xwm ntawm autologous platelet gel (APG) los pab txhawb kev loj hlob ntawm cov hlwb endothelial tau lees paub los ntawm kev sim hauv vitro [15]. PRP xav tias yuav muaj txiaj ntsig zoo ntawm lub ntsej muag rejuvenation thiab tiv thaiv kev laus vim nws muaj peev xwm los pab txhawb kev tsim collagen, fibroblast proliferation, thiab hyaluronic acid tiam kom dermal elasticity thiab keratinocyte proliferation [16-17].
Feem ntau ntawm PRP siv rau daim tawv nqaij rejuvenation los yog anti-aging yog txhaj. Feem ntau cov kev kho PRP ntawm lub ntsej muag rau rejuvenation yog kev txhaj tshuaj subdermal thiab tsawg heev cov tshuaj PRP nrog GFC daim ntawv thov tau kawm. Tshuaj pleev GFs tuaj yeem hla daim tawv nqaij teeb meem thiab khi rau ntawm tes saum npoo receptors, uas ua rau lub teeb liab cascade thiab txhawb nqa keratinocyte proliferation.
Txhawm rau kom tau txais txiaj ntsig zoo tshaj plaws los ntawm kev loj hlob, nws feem ntau xav tias platelets yuav tsum muaj qhov siab tshaj plaws; Txawm li cas los xij, yog tias WBCs ib txhij muaj siab nyob rau hauv cov platelet feem, cov txiaj ntsig zoo ntawm kev loj hlob tuaj yeem raug txo. Ntau qhov kev tshawb fawb pom tau hais tias muaj WBCs thiab RBCs ua rau muaj kev puas tsuaj rau cov txiaj ntsig kho tau pom los ntawm cov txiaj ntsig kev loj hlob tawm. Feem ntau cov khoom lag luam muaj PRP npaj tsis tshem tawm RBCs thiab WBCs thiab yog li tsis txhob siv cov tshuaj acellular loj hlob zoo uas muaj ntau yam zoo. Cov txheej txheem Wockhardt muab cov txiaj ntsig ntawm acellular loj hlob los ntawm cov neeg mob ntshav.
Wockhardt's Autologous Growth Factor Concentrate (AGFC), MYOWNN ™, yog ib daim ntawv thov ntawm cov plasma tseem ceeb uas tau ua tiav kom muaj cov ntshav siab ntau ntawm cov platelets thiab cov txiaj ntsig kev loj hlob tab sis muaj qhov zoo dua li ib txwm PRP nyob rau hauv uas nws yog acellular thiab loj hlob zoo nplua nuj, xws li tsis muaj cov qe ntshav liab (RBCs) thiab neutrophils uas yuav ua rau mob thiab mob tom qab kho. Txoj kev tshawb no tau tsim los ntsuas kev nyab xeeb thiab kev ua tau zoo ntawm cov tshuaj pleev ib ce ntawm lub ntsej muag - MYOWNN ™ rau kev tiv thaiv kev laus thiab lub ntsej muag rejuvenation.
Cov ntaub ntawv thiab cov txheej txheem
Txoj kev tshawb no tau ua los ntawm thoob ntiaj teb cov qauv lees paub ntawm Kev Kho Mob Zoo (GCP) (raws li tau hais tseg hauv ICH E6 Cov Lus Qhia rau GCP), pom zoo nrog Daim Ntawv Tshaj Tawm ntawm Helsinki, thiab ua raws li cov cai hauv zos. Pawg neeg saib xyuas kev ncaj ncees tau txais kev pom zoo los ntawm Wockhardt Tsev Kho Mob Institutional Review Board (ECR/624/Inst/MH/2014/RR-17) thiab Cutis Institutional Ethics Committee (ECR/930/Inst/KA/2017/RR{{6} }).
Nyob rau hauv hom kev kawm qhib daim ntawv lo, 50 tus neeg kawm (26 tus poj niam thiab 24 txiv neej) nrhiav lub ntsej muag ntawm daim tawv nqaij rejuvenation nrog Fitzpatrick daim tawv nqaij hom III-V [18] uas tsis tau noj ib qho kev kho qhov ncauj lossis tshuaj pleev ib ce tsawg kawg plaub lub lis piam ua ntej thiab ib qho twg. PRP-raws li kev kho mob (txhaj tshuaj) tsawg kawg rau lub hlis ua ntej kev kuaj xyuas tau raug xaiv los ntawm ob lub chaw hauv Is Nrias teb. Cov txheej txheem cais tawm yog cov pob txuv nquag, platelet suav tsawg dua 150, 000 µl, paub keeb kwm ntawm los ntshav los yog hemoglobinopathies, lossis keeb kwm ntawm cov kab mob uas ua rau muaj kev tiv thaiv kab mob cuam tshuam rau lub peev xwm los kho cov ntaub so ntswg. Ua kom tiav cov ntsiab lus ntawm txoj kev kawm tau nthuav tawm rau txhua yam kev kawm thiab tau txais kev pom zoo sau ntawv.
Rau cov kev kawm uas ua tau raws li kev tsim nyog tau txais thiab pom zoo koom nrog hauv txoj kev tshawb no, kev ntsuam xyuas lub ntsej muag tau ua tiav siv Visage-LS (dermaindia®, Tamil Nadu, India) thiab lub ntsej muag tsom xam; Cov ntshav tau sau rau AGFC cov ntshav qab zib. Cov ntaub ntawv pej xeem, cov cim tseem ceeb, thiab kev soj ntsuam hauv chav kuaj tau ua los ntsuas kev tsim nyog thiab kev nyab xeeb thaum kawm. Ua ntej thov cov tshuaj pleev ib ce, cov neeg kawm tau qhia kom ntxuav lawv lub ntsej muag, thiab yog tias muaj qhov ziab ntawm lub ntsej muag, lawv raug tso cai siv cov tshuaj moisturizer tsawg kawg 20 feeb ua ntej daim ntawv thov AGFC serum. Txawm li cas los xij, nyob rau hauv rooj plaub ntawm cov tawv nqaij oily, kev siv cov moisturizer tsis pom zoo. Cov neeg kawm raug hais kom siv tshuaj pleev thaiv hnub (tsawg kawg 30 SPF) txhua peb mus rau plaub teev thaum nruab hnub rau tag nrho lub sijhawm kawm. Cov ntsiab lus tau qhia kom zam txhua yam khoom kom zoo nkauj, mus ntsib spa, lwm yam kev kho mob ntawm lub ntsej muag, thiab raug tshav ntuj ntau dhau thaum kawm.
Cov ntshav sau rau AGFC kev npaj tau raug xa mus rau Wockhardt lub chaw ua haujlwm hauv kev ntim khoom pov thawj. Cov ntshav vacutainers tau centrifuged cais cov platelets thiab tom qab ntawd qhib los ntawm Wockhardt proprietary activator kom tau txais kev loj hlob zoo concentrate (GFC), uas tau muab rho tawm los ntawm cov ntshav. Extracted GFC tau kis aseptically mus rau hauv cov iav tsis muaj menyuam, uas tau muab tso rau hauv lyophilizer. Lub lyophilization ntawm GFC koom nrog peb cov kauj ruam yooj yim, piv txwv li, khov, thawj qhov ziab (sublimation), thiab ziab theem nrab. Lyophilized GFC tom qab ntawd rov tsim kho nrog cov kab mob hauv lub cev thiab Wockhardt proprietary permeabilizing tus neeg sawv cev kom tau txais cov khoom tiav. Cov khoom tiav raug xa tawm ntawm 2-8 degree mus rau qhov chaw kawm rau kev xa mus rau cov kev kawm ntxiv.
AGFC cov ntshav tau muab xa mus rau qhov kev kawm rau kev thov txhua hnub. Cov neeg kawm tau qhia kom ua ib daim ntawv thov hauv zos ntawm lub ntsej muag ib hnub ib hmos, kwv yees li 30 feeb ua ntej pw, nyiam dua. Qhov kev npaj uas tau muab xa tawm yog txaus rau kev siv tshuaj pleev ib ce rau ntawm lub ntsej muag ib hnub ib zaug thaum pw hauv peb lub hlis. Thaum kawg ntawm 3 lub hlis, cov neeg kawm tau txais kev pom zoo los ntsuam xyuas lawv qhov kev txaus siab koom nrog 2 lub hlis ntxiv xws li mus txog rau tsib lub hlis kawg. Tawm ntawm 50 yam kev kawm, 36 tau pom zoo koom nrog ob lub hlis ntxiv thiab muab ntshav rau AGFC kev npaj.
Tag nrho cov kev kawm no tau raug soj ntsuam txhua lub hlis txog Lub Hlis 3 thiab cov neeg uas pom zoo rov los ntshav tau ua raws li Lub Hlis 5. Thaum txhua lub hlis mus ntsib, cov neeg kawm raug soj ntsuam rau cov xwm txheej tsis zoo, tshuaj noj sib xyaw ua ke, tshuaj xyuas lub ntsej muag, tshuaj xyuas qhov tseem ceeb, kev kho raws cai. txij li thaum kawg mus ntsib, thiab kev ntsuam xyuas lub ntsej muag los ntawm lub ntsej muag tsom xam system. Lub hom phiaj tsom xam tau ua los ntawm Visage-LS, lub ntsej muag tsom xam, uas yog cov cuab yeej siv tshuaj ntsuam xyuas cov tawv nqaij ua tiav nrog rau kev tua, tshuaj xyuas, thiab kev ua haujlwm. Nws txais RGB (Red Blue Green), ultraviolet (UV), thiab lub teeb polarized (PL 3) spectrums ua ke nrog kev txawj ntse txawj ntse thiab duab tsom xam tshuab. Nws muab cov xwm txheej nyob ntawm pob, pores, noo noo, textures, wrinkles, thiab pigmentation. Kev tsom xam cov ntsiab lus tau ua los ntawm kev lees paub thoob ntiaj teb thiab siv tau cov nplai zoo li tus kws kho mob lub ntiaj teb kev txhim kho kev zoo nkauj (PGAIS), kev kawm thoob ntiaj teb kev zoo nkauj txhim kho nplai (SGAIS), cov qhab nia txaus siab (SSS), thiab qhov ntsuas qhov hnyav (WSRS). PGAIS thiab SGAIS tau qhab nia ntawm 1 mus rau 5, nrog 1 ua ntau zuj zus, 2 ua phem, 3 tsis hloov, 4 tau txhim kho, thiab 5 tau txhim kho ntau. WSRS tau qhab nia ntawm 1 mus rau 5, nrog 1 tsis tuaj, 2 ua me, 3 ua nruab nrab, 4 ua hnyav, thiab 5 yog qhov hnyav. SSS tau qhab nia ntawm 1 txog 6, 1 tsis txaus siab, 2 tsis txaus siab, 3 tsis txaus siab, 4 txaus siab me ntsis, 5 txaus siab, thiab 6 txaus siab heev.
Txhua qhov kev txheeb xyuas txheeb xyuas tau ua tiav siv SAS software, Version 9.4 (SAS Institute Inc., Cary, NC). Thawj qhov kev ua tau zoo kawg yog xam raws li qhov nruab nrab ntawm rau ntawm daim tawv nqaij tiv thaiv kev laus (spots, pores, wrinkles, kev ntxhib los mos, noo noo, thiab pigmentation) ntsuas los ntawm lub ntsej muag tsom xam (Visage-LS). Qhov kev ua tau zoo thib ob yog cov tawv nqaij tiv thaiv kev laus (spots, pores, wrinkles, kev ntxhib los mos, noo noo, thiab pigmentation) los ntawm lub ntsej muag tsom xam, PGAIS, SGAIS, SSS, thiab kev ntsuam xyuas duab (siv WSRS scale).
Ib qho qauv sib xyaw rau kev ntsuas rov qab tau siv rau lub hom phiaj no. Tus qauv tau hloov pauv los ntawm cov hauv paus ntsiab lus raws li qhov sib txawv ntawm kev mus ntsib raws li qhov tseem ceeb thiab cov txiaj ntsig kev ntsuam xyuas hauv paus raws li covariate. Tag nrho cov ntsiab lus tseem ceeb thiab theem nrab kev ua tau zoo tau txheeb xyuas los ntawm kev hloov kho Lub Hom Phiaj-rau-Treat mITT cov pej xeem.
Cov txiaj ntsig
Ntawm 50 yam uas tau tso npe kawm, 26 yog poj niam thiab 24 yog txiv neej. Cov neeg mob lub hnub nyoog nruab nrab yog 40 xyoo, txij li 30 txog 55 xyoo nrog tus qauv sib txawv ntawm 8.62 xyoo. Raws li Fitzpatrick scale, 14 yam (28 feem pua) muaj hom III ntawm daim tawv nqaij, thaum 27 tus neeg mob (54 feem pua) muaj hom IV thiab cuaj tus neeg mob (18 feem pua) muaj hom V.
Tag nrho ntawm tsib qhov xwm txheej tsis zoo tau raug tshaj tawm thaum lub sijhawm kawm thiab tsis muaj qhov xwm txheej no raug suav hais tias cuam tshuam nrog kev kawm kho mob. Cov xwm txheej tsis zoo no yog erythema, hypothyroidism, kab mob coronavirus (COVID) kab mob, thiab ob qhov xwm txheej ntawm pob txuv. Tsis muaj cov xwm txheej tsis zoo lossis cov xwm txheej cuam tshuam txog kev kho mob tau tshaj tawm thaum lub sijhawm kawm, nrog rau tsis muaj cov xwm txheej tsis zoo uas ua rau kev kawm tsis tiav.
Cov txiaj ntsig tau raug tshuaj xyuas los ntawm 47 cov ntsiab lus rau Lub Hlis 3 thiab 33 cov ntsiab lus rau Lub Hlis 5 uas ua tau raws li cov qauv rau cov pej xeem mITT. Cov pej xeem hauv mITT suav nrog cov ncauj lus uas siv tsawg kawg ib koob tshuaj ntawm kev kawm tshuaj thiab muaj tsawg kawg yog ib qho kev ntsuas kev ua tau zoo tom qab.
Nyob rau hauv kev soj ntsuam kev soj ntsuam nyob rau hauv cov pej xeem mITT, muaj ib tug statistically tseem ceeb feem pua kev hloov nyob rau hauv ib tug nruab nrab ntawm rau ntawm daim tawv nqaij los tiv thaiv kev laus tsis (spots, pores, wrinkles, kev ntxhib los mos, noo noo, thiab pigmentation) los ntawm lub hauv paus rau lub hli 5. Qhov kev txhim kho nyob rau hauv feem pua ntawm cov kev hloov pauv. nyob rau hauv qhov nruab nrab ntawm rau ntawm daim tawv nqaij tiv thaiv kev laus tsis tau pib txoj cai los ntawm Lub Hlis 3 (p-tus nqi ntawm 0.1047) tab sis kev txhim kho tseem ceeb tau pom los ntawm Lub Hlis 5 (p-tus nqi ntawm 0.0150) ( Table 1).
Thaum kawg ntawm Lub Ib Hlis 5, PGAIS qhov qhab nia siab tshaj plaws ntawm 4 lossis 5, piv txwv li kev txhim kho lossis kev txhim kho ntau, feem, tau tshaj tawm hauv 100 feem pua ntawm cov xwm txheej (Daim duab 1), thiab ntawm cov kab zoo sib xws, cov kev kawm kuj tau ntsuas SGAIS raws li qhov Qhov qhab nia siab tshaj plaws ntawm 4 lossis 5, piv txwv li kev txhim kho lossis kev txhim kho ntau, feem, hauv 100 feem pua ntawm cov mob (Daim duab 2).
Cov kev kawm raug nug kom ntsuas lawv qhov kev txaus siab rau SSS, yog li thaum kawg ntawm Lub Ib Hlis 5, pom tias 12.12 feem pua ntawm cov neeg kawm tau txaus siab rau kev kho mob, 84.85 feem pua cov neeg kawm txaus siab, 3.03 feem pua cov kawm txaus siab rau kev kho mob, thiab tsis muaj ib qho ntawm cov kev kawm tsis txaus siab (Daim duab 3).
Ntawm qhov kev ntsuam xyuas ntawm WSRS, nws tau pom tias tsawg kawg ib qho kev txhim kho ntawm wrinkles tau pom hauv 14.89 feem pua ntawm cov neeg mob thaum kawg ntawm Lub Hlis 3, uas tau txhim kho mus rau 37.5 feem pua thiab 48.48 feem pua ntawm lub hli 4 thiab 5. raws li ( Table 3, Daim duab 4). Kev txhim kho kev yees duab los ntawm lub hauv paus mus txog rau thaum xaus Lub Hlis 5 yog piav qhia hauv daim duab 5.
Kev soj ntsuam rhiab heev kuj tau ua los ntsuas qhov ua tau zoo ntawm daim tawv nqaij los tiv thaiv kev laus ntawm cov neeg muaj hnub nyoog tshaj 50 xyoo hauv mITT cov pej xeem. Qhov feem pua ntawm qhov nruab nrab hloov ntawm lub hauv paus mus rau Lub Hlis 3 (Hnub 105) yog 4.1 piv rau qhov kev hloov pauv nruab nrab ntawm tag nrho cov pejxeem ntawm 3.5, qhov nruab nrab feem pua ntawm cov hauv paus hloov mus rau Lub Hlis 5 (Hnub 165) yog 7.3 piv. rau qhov kev hloov nruab nrab pom hauv tag nrho cov pej xeem ntawm 5.0. Rau cov tib neeg tsis zoo li kev ntxhib los mos thiab wrinkles zoo ib yam li tag nrho cov pej xeem thiab cov qauv ntawm qhov nruab nrab feem pua ntawm kev hloov pauv los ntawm lub hauv paus rau Lub Hlis 3 (Hnub 105) thiab Lub Hlis 5 (Hnub 165) tau pom. Qhov feem pua ntawm cov ntaub ntawv hloov pauv tseem ceeb tau pom nyob rau hauv qhov tsis txaus ntseeg ntawm Lub Hlis 5 (p-value=0.0274) txawm tias qhov me me (N=6) ntawm cov neeg hnub nyoog no. Rau kev ntsuam xyuas PGAIS thiab SGAIS, ntawm Lub Hlis 5 (Hnub 165), txhua tus neeg mob (6 (100.0 feem pua) ntawm 6 tus neeg mob) tau tshaj tawm cov qhab nia ntawm 4 thiab 5. Raws li SSS, txhua tus neeg mob tau txaus siab rau kev kho mob ntawm Lub Hlis 3 (Hnub 105). ) thiab hli 5 (Hnub 165). Rau WSRS, ntawm Lub Hlis 5, tsib (83 feem pua) ntawm rau tus neeg mob tau qhab nia nruab nrab ntawm 1 thiab 3, thiab ib qho (16.67 feem pua) ntawm rau tus neeg mob tau qhab nia ntawm 4; tsis muaj ib qho ntawm cov ncauj lus qhia tau qhab nia ntawm 5.
Kev sib tham
Ib puag ncig yam tseem ceeb thiab kev laus ua rau peb cov tawv nqaij thiab nws tus kheej rejuvenation ntawm daim tawv nqaij yog txhawb los ntawm intrinsic loj hlob yam uas yog generated los ntawm peb cov hlwb. Raws li piv rau cov tawv nqaij hluas, cov tawv nqaij laus ua rau muaj kev loj hlob tsawg dua, uas pom tau tias nws tsim nyog rau kev siv cov khoom tu tawv nqaij tsis tu ncua nrog rau kev loj hlob ntawm cov hnub nyoog los txo qis cov tsos mob ntawm kev laus xws li wrinkles, kev ntxhib los mos, kab zoo, thiab lub suab [19]
Qhov cuam tshuam ntawm peb qhov kev txhaj tshuaj PRP tshaj li 12 lub lis piam tau soj ntsuam ntawm infraorbital wrinkles thiab cov tawv nqaij laus hauv cov neeg Esxias hauv kev kawm sib cais; Txoj kev tshawb no tau pom tias muaj kev txhim kho tseem ceeb hauv ob qho tib si wrinkles thiab tawv nqaij tone hauv daim tawv nqaij infraorbital [20]. Dermaroller daim ntawv thov ntawm PRP hla qhov kev kawm ntawm thaj chaw malar thiab hauv pliaj nrog rau kev txhaj tshuaj PRP rau hauv cov tawv nqaij ntawm ko taw ob lub lis piam rau peb zaug pom qhov sib txawv tseem ceeb hauv daim tawv nqaij firmness, wrinkles, thiab pom dav dav raws li qhov ntsuas ntsuas ntawm cov neeg mob ua ntej thiab tom qab. peb daim ntawv thov PRP, qhov uas ib tus kws kho mob dermatologists, qhov sib txawv tseem ceeb tau pom tsuas yog hauv daim tawv nqaij firmness-sagging [17].
Qee qhov kev tshawb fawb tswj tau tsawg tau ua los ua pov thawj tias cov tshuaj pleev xim GFs tuaj yeem txhawb nqa collagen synthesis thiab epidermal thickening, uas cuam tshuam nrog kev txhim kho kev kho mob hauv cov cim ntawm kev yees duab. Tsis tas li, kev tshawb fawb tsawg heev tau siv lub hom phiaj tsom xam lub ntsej muag los ua kom pom kev txhim kho nrog kev siv AGFC.
Hauv txoj kev tshawb no, ob qho tib si kev tshuaj xyuas lub hom phiaj nrog lub ntsej muag tsom xam zoo li Visage-LS, nrog rau kev tsom xam cov ntsiab lus nrog cov ntsuas thoob ntiaj teb lees paub xws li PGAIS, SGAIS, SSS, thiab WSRS tau ua nrog cov ntawv thov ntawm AGFC.
Hauv txoj kev tshawb no qhib daim ntawv lo, daim ntawv thov hauv zos niaj hnub ntawm AGFC rau ntawm lub ntsej muag rau peb lossis tsib lub hlis tau pom tias muaj kev txhim kho tseem ceeb hauv qhov nruab nrab ntawm rau ntawm daim tawv nqaij tiv thaiv kev laus (spots, pores, wrinkles, kev ntxhib los mos, noo noo, thiab pigmentation) los ntawm lub hauv paus. . Kev txhim kho ntawm feem pua ntawm cov kev hloov pauv ntawm qhov nruab nrab ntawm rau ntawm daim tawv nqaij los tiv thaiv kev laus tsis tau pib txij Lub Hlis 3 tab sis kev txhim kho tseem ceeb tau pom los ntawm Lub Hlis 5.
Ib qho piv txwv tseem ceeb hloov pauv ntawm cov tawv nqaij tiv thaiv kev laus xws li ya raws, kev ntxhib los mos, thiab wrinkles kuj pom. Muaj ib qho kev txhim kho tseem ceeb hauv daim tawv nqaij ntawm qhov kawg ntawm tsib lub hlis ntawm daim ntawv thov nrog p-tus nqi ntawm 0.0054, qhov kev txhim kho zoo sib xws tau pom nyob rau hauv noo noo thaum ntxov thaum kawg ntawm plaub lub hlis ntawm daim ntawv thov nrog p-tus nqi ntawm 0.0130, uas ntxiv txhim kho los ntawm qhov kawg ntawm tsib lub hlis ntawm daim ntawv thov nrog p- tus nqi ntawm 0.0006. Kev txhim kho sai tshaj plaws thiab ntxov tshaj plaws ntawm cov tawv nqaij tiv thaiv kev laus tau pom hauv daim tawv nqaij wrinkles; ib qho kev txhim kho tseem ceeb hauv cov wrinkles tau pom thaum ntxov thaum kawg ntawm peb lub hlis ntawm daim ntawv thov nrog p-tus nqi ntawm 0.0387, uas tau txhim kho ntxiv los ntawm qhov kawg ntawm plaub lub hlis ntawm daim ntawv thov nrog p-tus nqi ntawm 0.0188, qhov kev txhim kho tshaj plaws. nyob rau hauv wrinkles tau pom los ntawm qhov kawg ntawm tsib lub hlis ntawm daim ntawv thov nrog p-tus nqi ntawm 0.0007. Kev txhim kho zoo sib xws tau pom nyob rau hauv cov neeg muaj hnub nyoog tshaj 50 xyoo, tshwj xeeb tshaj yog nyob rau hauv tus kheej tsis zoo li kev ntxhib los mos thiab wrinkles.
Peb txoj kev tshawb fawb tau ua raws li lwm cov kev tshawb fawb uas tau siv cov tshuaj PRP, thiab peb txoj kev tshawb fawb kuj tau siv lub hom phiaj siab tshaj plaws ntawm lub ntsej muag tsom xam los ntsuas qhov sib txawv.
Tsis muaj cov xwm txheej tsis zoo lossis cov xwm txheej cuam tshuam txog kev kho mob tau tshaj tawm thaum lub sijhawm kawm thiab tsis muaj cov xwm txheej tsis zoo uas ua rau kev kawm tsis txuas ntxiv. Tsis muaj lub ntsiab lus tseem ceeb hauv kev soj ntsuam kev hloov pauv cuam tshuam txog kev soj ntsuam thiab tsis muaj kev hloov pauv tseem ceeb hauv cov cim tseem ceeb tsis tau pom thaum lub sijhawm kawm.
Peb txoj kev tshawb fawb muaj ob peb yam kev txwv xws li cov qauv me me. Tsis tas li ntawd, qhov no yog ib qho kev tshawb fawb tsis sib piv tab sis cov kev tshawb fawb sib piv yog qhov nyuaj rau kev tsim hauv qhov kev qhia no, vim qhov sib txawv ntawm cov tawv nqaij ntawm tus kheej thiab cov tawv nqaij laus yog qhov siab heev thiab tuaj yeem cuam tshuam cov txiaj ntsig.
Cov lus xaus
Kev txhim kho nyob rau hauv nruab nrab ntawm rau ntawm daim tawv nqaij tiv thaiv kev laus tsis, nrog rau tus kheej tsis xws li wrinkles, ya raws, thiab kev ntxhib los mos, depicted los ntawm lub hom phiaj tsom xam nrog lub ntsej muag tsom xam system tau ua tiav los ntawm subjective tsom xam ua los ntawm txawv ntiaj teb no teev xws li PGAIS, SGAIS, SSS. , thiab WSRS. Tsis muaj kev txhawj xeeb txog kev nyab xeeb pom nrog kev siv MYOWNN ™ hauv txoj kev tshawb no, thiab kev nyab xeeb mus sij hawm ntev tau raug soj ntsuam hauv kev tshawb fawb tsis tu ncua.
Hauv kev xaus, txoj kev tshawb no tau pom tias cov tshuaj MYOWNN ™ kev kho mob tau pib qhia qhov sib txawv thaum ntxov li peb lub hlis nrog kev txhim kho tseem ceeb los ntawm Lub Hlis 5, thiab MYOWNN ™ tuaj yeem siv nyab xeeb thiab siv tau zoo rau kev tiv thaiv kev laus thiab lub ntsej muag rejuvenation.
Cov ntaub ntawv ntxiv
Qhia tawm
Tib neeg cov ntsiab lus: Kev pom zoo tau txais lossis zam los ntawm txhua tus neeg koom hauv txoj kev tshawb no. 1. Cutis Institutional Ethics Committee thiab 2. Wockhardt Tsev Kho Mob Institutional Review Board tau tso cai 1. ECR/930/Inst/KA/2017/RR{5}} thiab 2. ECR/624/Inst/MH/2014/RR{{ 9}} ib. 1. Cutis Institutional Ethics Committee: Peb pom zoo rau txoj kev tshawb no los ua nws daim ntawv qhia; 2. Wockhardt Tsev Kho Mob Institutional Review Board: Txoj kev tshawb fawb tau pom zoo tom qab koj xa cov txheej txheem rau pawg neeg saib xyuas. Peb pom zoo rau qhov kev tshawb fawb saum toj no los ua hauv daim ntawv qhia. Tsiaj txhu: Txhua tus kws sau ntawv tau lees paub tias qhov kev tshawb fawb no tsis suav nrog cov tsiaj ntawv lossis cov ntaub so ntswg. Kev tsis sib haum xeeb ntawm kev txaus siab: Ua raws li daim ntawv qhia txog ICMJE, txhua tus kws sau ntawv tshaj tawm cov hauv qab no: Cov ntaub ntawv them nyiaj / kev pabcuam: Txhua tus kws sau ntawv tau tshaj tawm tias tsis muaj kev txhawb nqa nyiaj txiag los ntawm ib lub koom haum rau kev xa ua haujlwm. Kev sib raug zoo nyiaj txiag: Txhua tus kws sau ntawv tau tshaj tawm tias lawv tsis muaj kev sib raug zoo nyiaj txiag tam sim no lossis hauv peb lub xyoos dhau los nrog rau txhua lub koom haum uas yuav muaj kev txaus siab rau cov haujlwm xa tuaj. Lwm yam kev sib raug zoo: Txhua tus kws sau ntawv tau tshaj tawm tias tsis muaj lwm yam kev sib raug zoo lossis kev ua ub no uas tuaj yeem tshwm sim los cuam tshuam rau kev xa tawm.
Kev lees paub
Peb xav lees paub Alisha M Padua thiab Pratiksha Nadkarni rau cov qauv ua qauv thiab kev npaj ntawm MYOWNN ™, Rahul Sakpal rau kev ua haujlwm phlebotomy ntawm Mumbai qhov chaw, thiab Ajaykumar Yadav, Dhananjay Kumbhar, thiab Harsha Pal rau lawv txoj kev txhawb nqa hauv kev tswj xyuas.
Cov ntaub ntawv
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