Ib Txoj Kev Siv Tshuaj Siv Tshuaj Tiv Thaiv Cisplatin-induced Nephrotoxicity

Department of Integrative Pharmacology, Mie University Graduate School of Medicine

Nyem qhov no kom tau txais Natural organic CISTANCHE EXTRACT nrog 25% ECHINACOSIDE thiab 9% ACTEOSIDE rau lub raum ua haujlwm

Cisplatin yog siv dav rau kev kho mob ntawmntau hom mob qog noj ntshav. Cisplatin-induced nephrotoxicity yog qhov hnyavkev tshwm sim tsis zoo, yav dhau los kev kho mob xws lihydration kev kho mobtsis txaus rautiv thaiv nephrotoxicity. Cisplatin-inducednephrotoxicity yog ib qho kev txwv tsis pub noj tshuaj thiab txwv kev siv tshuaj kho mob. Hauv kev tshawb fawb tam sim no, pebsiv cov tshuaj repositioning mus kom ze los txheeb xyuas cov tshuaj tiv thaiv tiv thaiv cisplatin-induced nephrotoxicity.

Sivpej xeem cov ntaub ntawv hais txog cov noob qhia profileing, peb txheeb xyuas palonosetron, 5HT3- receptor antagonist, raws li atshuaj tiv thaiv rau cisplatin-induced nephrotoxicity. Siv cov ntaub ntawv ntawm tus kheej tshaj tawm cov xwm txheej tsis zoo, peb tau nthuav tawmtias qhov qhia txog qhov sib txawv ntawm palonosetron rau cisplatin-induced nephrotoxicity yog qhov tsawg, tab sis tsis muajCov cim tseem ceeb tau pom nrog lwm tus 5HT3- receptor antagonists. Siv cov ntaub ntawv kho mob hauv hluav taws xob ntawm MieTsev Kho Mob Tsev Kho Mob, peb tau lees paub qhov kev tiv thaiv ntawm palonosetron tiv thaiv cisplatin-induced nephrotoxicity hauvCov neeg mob uas tau txais cisplatin thiab fluorouracil kho nrog palonosetron lossis ramosetron.

Qhov siab ntawmntshav qab zibcreatinine uathiabntshav ureanitrogen induced los ntawm chemotherapy nrog palonosetron yog ho qis dua cov ntawmcov ramosetron. Peb kuj tuaj yeem ua kom pom tias palonosetron tab sis tsis yog lwm yam 5HT3- receptor antagonistsameliorated cov ciaj sia taus ntawm zebrafish raug rau cisplatin. Cov kev tshawb pom no qhia tias palonosetrons tuaj yeem txo qisCisplatin-induced nephrotoxicity.