Hu rau: jerry.he@wecistanche.com

Cistanche zoo heev rau lub raum ua haujlwm

Lub raumcell carcinoma (RCC) yog ib qho ntawm kaum feem ntau mob qog noj ntshav thoob ntiaj teb, suav txog kwv yees li 2 feem pua ​​​​ntawm tag nrho cov qog nqaij hlav.

01

3 mus rau 5 feem pualub raumcell carcinomas yog cov kab mob sib kis

Genetic syndromes txuam nroglub raumcell carcinoma muaj xws li VHL syndrome, BAPT1 mutant disease, succinate dehydrogenase-associated lub raum mob cancer, hereditary leiomyomatosis, hereditary papillary renal carcinoma, Birt-Hogg-Dubé syndrome, Tuberous sclerosis complex, Cowden syndrome, thiab hyperparathyroidism.

Kev sab laj txog caj ces yuav tsum tau txiav txim siab hauv cov neeg mob hnub nyoog 46 xyoo thiab qis dua. Cov hnub nyoog yau thiab ob sab/multicentric lesions yog qhov zoo-pom zoo ntawm caj ceslub raumcell carcinoma.

02

Hauv qee cov neeg, kev soj ntsuam nquag yog qhov kev xaiv tsim nyog

Kev soj ntsuam nquag yog qhov kev xaiv thawj zaug tsim nyog rau cov neeg mob me lossis Bosniak 3/4 cysticlub raumcell carcinoma, tshwj xeeb tshaj yog rau pawg<2>

Cov kws kho mob yuav tsum ua qhov tseem ceeb rau kev saib xyuas cov neeg mob zoo li no thaum qhov kev cia siab ntawm kev cuam tshuam ntau dua qhov muaj txiaj ntsig oncological ntawm kev kho mob hnyav.

Cov kws kho mob yuav tsum ua nruj ua tsiv lossis rov ua cov kev tshawb fawb txog kev yees duab ntawm 3-6 lub hlis hauv cov neeg mob uas muaj kev pheej hmoo tsis txaus ntseeg thiab cov txiaj ntsig ntawm kev kho mob lossis cov uas nyiam saib xyuas.

Cov kev tshawb fawb tau pom tias 5-xyoo muaj sia nyob tus nqi ntawm cov neeg mob tau txais kev soj ntsuam nquag yog 70 feem pua.

03

Targeted therapy ntxiv rau immunotherapy

Lub raumcell carcinoma yog ib hom tshuaj kho mob-refractory cancer. Cov kev kho mob rau metastatic clear celllub raumCov kab mob qog noj ntshav muaj xws li kev kho mob lossis kev tiv thaiv kab mob, thiab cov pov thawj tshiab txhawb kev sib xyaw ntawm kev kho mob thiab kev tiv thaiv kab mob rau cov kab mob metastatic.

Tam sim no, cov hom phiaj kho raulub raumcell carcinoma muaj xws li axitinib, bevacizumab, cabozantinib, lenvatinib, pazopanib, sunitinib, thiab sorafenib, nrog rau cov phiaj xwm rapamycin Targeted tshuaj everolimus thiab temsirolimus ntawm tincine complex 1 (mTORC1).

Tam sim no thawj kab immunotherapy regimens rau siab heevlub raumcell carcinoma muaj xws li nivolumab plus ipilimumab, axitinib plus avelumab, thiab axitinib plus pembrolizumab.

Tsis tas li ntawd, peb txoj kev tshawb fawb tsis ntev los no tau ntsuas sunitinib nrog peb txoj kev tiv thaiv kab mob tiv thaiv kab mob (axitinib ntxiv rau pembrolizumab, atezolizumab ntxiv rau bevacizumab, nivolumab) ntxiv rau ipilimumab) hauv sarcomatoid.lub raumcell carcinoma, thiab immunocombination therapy tau pom tias muaj txiaj ntsig zoo dua li sunitinib hauv peb qhov kev tshawb fawb.

04

Folic acid kho cov kev mob tshwm sim

Mucositis feem ntau pom nyob rau hauv metastaticlub raumcell carcinoma kho nrog lub hom phiaj kev kho mob thiab immunotherapy thiab tej zaum yuav cuam tshuam rau cov neeg mob lub neej zoo los yog ua rau txo koob tshuaj los yog kev kho mob tsis tu ncua.

Cov kws kho mob tuaj yeem kwv yees qhov hnyav ntawm mucositis hauv cov neeg mob. Kwv yees li ntawm 20 feem pua ​​​​ntawm cov neeg mob tau txais kev kho mob tsim cov kab mob mucositis, thiab cov phiaj xwm kev kho mob ua rau lub qhov ncauj mucosal toxicity uas txawv ntawm cov kab mob hauv qhov ncauj tau pom nrog cytotoxic chemotherapy lossis hluav taws xob. Kev kho mob mucositis suav nrog kev saib xyuas qhov ncauj zoo txhua hnub thiab kev kho hniav tsis tu ncua.

Ib txoj kev tshawb fawb me me tsis ntev los no tau pom tias cov tshuaj folic acid txo cov txiaj ntsig ntawm sunitinib, pazopanib, everolimus, axitinib, temsirolimus, interleukin-2/interferon-alpha, carbo Qib 2 lossis siab dua cov tsos mob ntawm mucositis tshwm sim los ntawm kev kho mob nrog tinib, bevacizumab. , thiab nivolumab. Tam sim no, ob qhov muag tsis pom kev, txoj kev tshawb nrhiav cov placebo-tswj yog tab tom ua.

05

ib nrab nephrectomy

Nrog rau qhov nce nrhiav kom tau me me (tshwj xeeb tshaj yog<7 cm)="">lub raumpawg thiab kev txhim kho ntawm txoj kev phais, ob qho tib si ASCO thiab NCCN cov lus qhia pom zoo ib feem ntawm nephrectomy thaum ua tau.

Ib nrab nephrectomy txo lub sij hawm ischemic thiab tau muab piv rau kev txo cov xwm txheej ntawm cov mob ntev.lub raumtsis ua hauj lwm, ncua kev mob plawv, thiab txhim kho txoj sia nyob.